Results 11 to 20 of about 4,325,962 (256)
A2B Adenosine Receptor and Cancer [PDF]
International Journal of Molecular Sciences, 2019 There are four subtypes of adenosine receptors (ARs), named A1, A2A, A2B and A3, all of which are G protein-coupled receptors (GPCRs). Locally produced adenosine is a suppressant in anti-tumor immune surveillance. The A2BAR, coupled to both Gαs and Gαi G
Zhang-Guo Gao, K. Jacobson
semanticscholar +3 more sources
Adenosine receptors and asthma [PDF]
British Journal of Pharmacology, 2008 The accumulation of evidence implicating a role for adenosine in the pathogenesis of asthma has led to investigations into all adenosine receptor subtypes as potential therapeutic targets for the treatment of asthma. Selective A1receptor antagonists are currently in preclinical development since adenosine has been shown experimentally to mediate ...
Brown, R A, Spina, D, Page, C P
openaire +3 more sources
Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]
, 2007 [spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core +6 more sources
Adenosine Receptors and Cancer [PDF]
, 2009 The A(1), A(2A), A(2B) and A(3) G-protein-coupled cell surface adenosine receptors (ARs) are found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, agonists or antagonists, modulates tumor growth via a range of signaling pathways.
Fishman P +6 more
openaire +2 more sources
Influence of adenosine receptor ligands on ketamine-induced anesthesia in mice
Current Issues in Pharmacy and Medical Sciences, 2012 The influence of adenosine receptor ligands on anesthetic activity of ketamine was studied in mice. Ketamine-induced anesthesia (100 mg/kg) was significantly increased by the higher doses of CPA (selective A1 adenosine receptor agonist) and NECA (A1 ...
Sylwia Fidecka, Marcin Mandryk
doaj +1 more source
Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
Nature Communications, 2019 Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali +12 more
semanticscholar +1 more source
Role of cGMP as second messenger of adenosine in the inhibition of renin release [PDF]
, 1988 Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin +5 more
core +1 more source
Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors [PDF]
Genomics & Informatics, 2013 The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors.
Hyun Keun Chee, S. June Oh
doaj +1 more source
Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
Frontiers in Cellular Neuroscience, 2019 Adenosine receptors (ARs) function in the body’s response to conditions of pathology and stress associated with a functional imbalance, such as in the supply and demand of energy/oxygen/nutrients.
K. Jacobson +3 more
semanticscholar +1 more source
Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine [PDF]
, 2015 This work was funded by the Wellcome Trust Institutional Strategic Support Fund for University of St. Andrews.Despite considerable evidence that glia can release modulators to influence the excitability of neighbouring neurons, the importance of ...
Miles, Gareth B. +5 more
core +2 more sources