Results 21 to 30 of about 4,325,962 (256)
Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
Cells, 2020 Many ligands directly target adenosine receptors (ARs). Here we review the effects of noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising adenosine levels by inhibiting adenosine transport (e.g., ticagrelor, ethanol, and ...
Kenneth A. Jacobson, Marc L. Reitman
doaj +1 more source
Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]
, 2003 In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B. +5 more
core +1 more source
Photoresponsive adenosine derivatives for optical control of adenosine A2A receptor in living cells [PDF]
, 2023 Subtype-selective ligands with photoswitchable properties are highly desired for photopharmacology of G protein-coupled receptors (GPCRs). We developed photoswitchable ligands targeting adenosine A2A receptor (A2AR), a GPCR subtype.
Tsuyoshi, Araya +7 more
core +2 more sources
The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis
Molecules, 2011 The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer +3 more
doaj +1 more source
Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase : an in vitro rat study [PDF]
, 2014 In the brain, extracellular adenosine increases as a result of neuronal activity. The mechanisms by which this occurs are only incompletely understood. Here we investigate the hypothesis that the Na+ influxes associated with neuronal signalling activate ...
Sims, Robert E. +6 more
core +2 more sources
Journal of Pharmacological Sciences, 2005 The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno +5 more
doaj +1 more source
Natural Product Communications, 2022 Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in an animal model.
Kazuya Kusama +8 more
doaj +1 more source
Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]
, 2015 The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte +2 more
core +1 more source
Annual Review of Physiology, 1992 Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue.
M E, Olah, G L, Stiles
openaire +4 more sources
A2A adenosine receptor functional states characterized by 19F-NMR
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance G protein-coupled receptor (GPCR) signaling from the extracellular orthosteric drug binding site across the cell membrane to the intracellular contact sites with G proteins and arrestins is enabled by inherent structural plasticity, which ...
L. Sušac +4 more
semanticscholar +1 more source