Results 41 to 50 of about 436,080 (311)

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]

, 2011
The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie, Hardie, D. G. (D. Grahame), Naomi Pentland, Simon Hawley, Frenguelli, Bruno, Doney, Alexander S., Pentland, Naomi, Frenguelli, Bruno G., Stephanie zur Nedden, Hawley, Simon, Alexander S. Doney, Bruno G. Frenguelli, Hardie, D. Grahame, Doney, Alexander S.; id_orcid, Zur Nedden, Stephanie   +14 more
core   +1 more source

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation [PDF]

, 2011
Background: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Jason Greenwald, Perozzo Remo, Greenwald Jason, Dirk Kostrewa, Leonardo Scapozza, Remo Perozzo, Kuettel Sabine, Perozzo, Remo, Shaheen Ahmed, Kostrewa Dirk, Scapozza Leonardo, Kuettel, Sabine, Greenwald, Jason, Scapozza, Leonardo, Ahmed Shaheen, Kostrewa, Dirk, Sabine Kuettel, Ahmed, Shaheen   +17 more
core   +1 more source

Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome

Frontiers in Cardiovascular Medicine, 2022
In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS.
Maria Carolina Guido, Natalia de Menezes Lopes, Camila Inagaki Albuquerque, Elaine Rufo Tavares, Leonardo Jensen, Priscila de Oliveira Carvalho, Thauany Martins Tavoni, Ricardo Ribeiro Dias, Lygia da Veiga Pereira, Francisco Rafael Martins Laurindo, Raul Cavalcante Maranhão   +10 more
doaj   +1 more source

Adenosine and Migraine [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998
ABSTRACT:Background:Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.Methods:We have investigated circulating ...
R, Guieu, C, Devaux, H, Henry, G, Bechis, J, Pouget, D, Mallet, F, Sampieri, M, Juin, R, Gola, H, Rochat   +9 more
openaire   +2 more sources

Adenosine Dysfunction and Adenosine Kinase in Epileptogenesis [PDF]

The Open Neuroscience Journal, 2010
Traditionally, epilepsy has been considered to be a disorder of neuronal dysfunction. Based on this dogma, drug development efforts have largely focused on neurocentric model systems to screen for compounds that affect the function of neurons. Unfortunately, about 30% of all patients with epilepsy - or more than 20 million worldwide - are refractory to
openaire   +2 more sources

The Impact of A3AR Antagonism on the Differential Expression of Chemoresistance-Related Genes in Glioblastoma Stem-like Cells

Pharmaceuticals
Glioblastoma (GB) is the most aggressive and common primary malignant tumor of the brain and central nervous system. Without treatment, the average patient survival time is about six months, which can be extended to fifteen months with multimodal ...
Liuba Peñate, Diego Carrillo-Beltrán, Carlos Spichiger, Alexei Cuevas-Zhbankova, Ángelo Torres-Arévalo, Pamela Silva, Hans G. Richter, Ángel Ayuso-Sacido, Rody San Martín, Claudia Quezada-Monrás   +9 more
doaj   +1 more source

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe   +2 more
core   +1 more source

Adenosine and adenosine antagonism in asthma [PDF]

Thorax, 1998
I read with interest the excellent update on adenosine by Polosa and Holgate.1 An important use of this challenge agent is demonstrated and adenosine antagonism as a potential treatment for asthma is revisited. However, the role of adenosine as a mediator of asthma is somewhat inconsistent with several functional observations.
C. PERSSON;, S. T HOLGATE
openaire   +1 more source

Adenosine and Sleep [PDF]

Current Neuropharmacology, 2009
Over the last several decades the idea that adenosine (Ado) plays a role in sleep control was postulated due in large part to pharmacological studies that showed the ability of Ado agonists to induce sleep and Ado antagonists to decrease sleep. A second wave of research involving in vitro cellular analytic approaches and subsequently, the use of ...
Bjorness, Theresa E, Greene, Robert W
openaire   +2 more sources

Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5′-Nucleotidase (CD73)

Frontiers in Pharmacology, 2020
The airways are a target tissue of type I allergies and atopy is the main etiological factor of bronchial asthma. A predisposition to allergy and individual response to allergens are dependent upon environmental and host factors.
Elisabetta Caiazzo, Ida Cerqua, Maria Antonietta Riemma, Roberta Turiello, Roberta Turiello, Armando Ialenti, Jurgen Schrader, Giuseppe Fiume, Carmen Caiazza, Fiorentina Roviezzo, Silvana Morello, Carla Cicala   +11 more
doaj   +1 more source