A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core +1 more source
Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation [PDF]
, 1989 There is a striking similarity between the effects of adenosine and of hypoxia or glucose depletion on membrane potential and conductance of hippocampal neurones in tissue slices of rat brain.
A. Spuler +15 more
core +1 more source
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Adenosine receptors (ARs) represent key drug targets in many human pathologies, including cardiovascular, neurologic, and inflammatory diseases. To overcome the very rapid metabolization of adenosine, metabolically stable AR agonists and antagonists were developed.
Rouquette, Marie +9 more
openaire +4 more sources
Stability of Diluted Adenosine Solutions in Polyolefin Infusion Bags [PDF]
, 2013 Background Intravenous or intracoronary adenosine is used in the cardiac catherization lab to achieve maximal coronary blood flow and determine fractional flow reserve.
Almagambetova, Elise +3 more
core +2 more sources
Computerized Modeling of Adenosine Triphosphate, Adenosine Triarsenate and Adenosine Trivanadate [PDF]
Molecules, 2012 Computerized molecular models of adenosine triphosphate, adenosine tri-arsenate and adenosine trivanadate have been generated using the molecular mechanics technique. The analysis of structural parameters indicated that, at least theoretically, adenosine triarsenate is a realistic candidate for replacement of adenosine triphosphate in biochemical ...
Nascimento, Valter A. +2 more
openaire +3 more sources
The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats
Behavioral Sciences, 2020 Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani +9 more
doaj +1 more source
Journal of Alzheimer's Disease, 2010 Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of ...
Ribeiro, Joaquim A., Sebastião, Ana M
openaire +3 more sources
Ionic basis of a differential effect of adenosine on refractoriness in rabbit AV nodal and atrial isolated myocytes [PDF]
, 1999 Methods: The whole cell patch clamp technique was used to record action potentials and ion currents in AV nodal and left atrial myocytes isolated enzymatically from rabbit hearts.
Kane, K.A., Rankin, A.C., Workman, A.J.
core +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Wall, Mark J. +2 more
core +2 more sources
Comparison between adenosine triphosphate bioluminescence and aerobic colony count to assess surface sanitation in the hospital environment [PDF]
, 2018 Background: Adenosine triphosphate bioluminescence produced by the firefly luciferase has been successfully introduced to verify cleaning procedures in the food industry according to the Hazard Analysis Critical Control Point program.
Alagna E. +8 more
core +1 more source