Results 51 to 60 of about 486,199 (215)
Erythrocytes enhance oxygen-carrying capacity through self-regulation
Frontiers in PhysiologyOnce considered passive carriers of oxygen, erythrocytes are now understood to play active roles in regulating oxygen homeostasis and redox balance. This review examines the molecular mechanisms through which red blood cells adapt to hypoxic conditions ...
Ying Xu +4 more
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The role of adenosine in preconditioning by brief pressure overload in rats
Journal of the Formosan Medical Association, 2015 Brief pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits has been previously reported. Its effects in other species are not known. This study investigates effects of pressure overload and the role of adenosine in rats
Cheng-Hsiung Huang +4 more
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Frontiers in Neurology, 2019 Epilepsy is a neurological disorder characterized by a long term propensity to produce unprovoked seizures and by the associated comorbidities including neurological, cognitive, psychiatric, and impairment the quality of life.
Fan Chen +3 more
doaj +1 more source
Current Neuropharmacology, 2009 Over the last several decades the idea that adenosine (Ado) plays a role in sleep control was postulated due in large part to pharmacological studies that showed the ability of Ado agonists to induce sleep and Ado antagonists to decrease sleep. A second wave of research involving in vitro cellular analytic approaches and subsequently, the use of ...
Bjorness, Theresa E, Greene, Robert W
openaire +2 more sources
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core +1 more source
Autoimmunity, 2007 T cells must integrate multiple environmental cues when deciding whether to mount an immunogenic or tolerogenic response. Since not all self-reactive T cells are eliminated during thymic development, mechanisms of peripheral tolerance such as T cell anergy contribute to preventing autoimmunity. Recent studies have implicated extracellular adenosine and
Paul E, Zarek, Jonathan D, Powell
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Modern Rheumatology, 2010 Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate.
Edwin S L, Chan, Bruce N, Cronstein
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Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]
, 2003 In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B. +5 more
core +1 more source
Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]
, 2011 Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam +37 more
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Molecules, 2022 The adenosine A2A receptor subtype is recognized as a non-dopaminergic pharmacological target for the treatment of neurodegenerative disorders, notably Parkinson’s disease (PD).
Akihisa Mori +5 more
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