Results 71 to 80 of about 486,199 (215)

CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue

Frontiers in Immunology
Next to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute to ...
Michelle Y. Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren   +6 more
doaj   +1 more source

Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

Deletion of murine slc29a4 modifies vascular responses to adenosine and 5‐hydroxytryptamine in a sexually dimorphic manner

Physiological Reports, 2020
Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5‐hydroxytryptamine (5‐HT) and adenosine across cell membranes.
Ran Wei, Stephen L. Gust, David Tandio, Alexia Maheux, Khanh H. Nguyen, Joanne Wang, Stephane Bourque, Frances Plane, James R. Hammond   +8 more
doaj   +1 more source

Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]

FEBS Letters, 2009
Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Park, Jae, Singh, Bhag, Gupta, Radhey S.
openaire   +2 more sources

Clinical Implications of Unmasking Dormant Conduction After Circumferential Pulmonary Vein Isolation in Atrial Fibrillation Using Adenosine: A Systematic Review and Meta-Analysis

Frontiers in Physiology, 2019
Purpose: Circumferential pulmonary vein isolation (CPVI) is a routine ablation strategy of atrial fibrillation (AF). The adenosine test can be used to unmask dormant conduction (DC) of pulmonary veins after CPVI, thereby demonstrating possible pulmonary ...
Cheng Chen, Daobo Li, Jeffery Ho, Tong Liu, Xintao Li, Zhao Wang, Yajuan Lin, Fuquan Zou, Gary Tse, Gary Tse, Yunlong Xia   +10 more
doaj   +1 more source

Interactions Between the Neuromodulator Adenosine and the Classic Transmitters

, 1987
The present studies give examples of three types of interactions between adenosine and classic neurotransmitters. First, the transmitter substances may influence the amount of adenosine formed locally.
Fastbom, J, van, der Ploeg I, Fredholm, BB, Dunér-Engstrom, M, Jonzen, B, Lindgren, E,, Nordstedt, C, Pedata, F   +7 more
core   +1 more source

Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles

Pharmaceutics, 2020
Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial skin for the treatment of skin wrinkles, a ...
Sooho Yeo, Sukkyun Jung, Heui Kyoung Cho, Young Ho Kim, Gi Hwan Kim, Dohyun Kim, Byoung Hyen Ko, Jaehwi Lee   +7 more
doaj   +1 more source

Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores

Frontiers in Pharmacology, 2017
Duchenne muscular dystrophy (DMD) is an X-linked disorder that leads to cardiac and skeletal myopathy. The complex immune activation in boys with DMD is incompletely understood.
Jonathan H. Soslow, Larry W. Markham, Larry W. Markham, W. Bryan Burnette, Cristi L. Galindo, Igor Feoktistov, Frank J. Raucci, Bruce M. Damon, Douglas B. Sawyer, Douglas B. Sawyer, Sergey Ryzhov   +10 more
doaj   +1 more source

Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells

Cells, 2020
Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs).
Sebastián Alarcón, María de los Ángeles Toro, Carolina Villarreal, Rómulo Melo, Rodrigo Fernández, Angel Ayuso Sacido, Daniel Uribe, Rody San Martín, Claudia Quezada   +8 more
doaj   +1 more source

Dual acting antioxidant A1 adenosine receptor agonists [PDF]

, 2007
Herein we report the synthesis and biological evaluation of some potent and selective A1 adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety.
Figler, Heidi, Urmaliya, Vijay, Scammells, Peter J., Pouton, Colin W., Linden, Joel, Gregg, Alison D., Devine, Shane M., White, Paul, Bottle, Steven E.   +8 more
core   +1 more source