Results 81 to 90 of about 436,080 (311)

Photoresponsive adenosine derivatives for optical control of adenosine A2A receptor in living cells

, 2023
Subtype-selective ligands with photoswitchable properties are highly desired for photopharmacology of G protein-coupled receptors (GPCRs). We developed photoswitchable ligands targeting adenosine A2A receptor (A2AR), a GPCR subtype.
Tsuyoshi, Araya, Tomohiro, Doura, Yuya, Matsuba, Hidetsugu, Asada, So, Iwata, Harufumi, Suzuki, Yuma, Matsuoka, Shigeki, Kiyonaka   +7 more
core   +1 more source

Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic Review and Meta-Analysis of Published Clinical Trials

Biomolecules
Research results suggest the potential of topical adenosine as a hair-promoting agent. The aim of this study was to examine the available clinical evidence of the efficacy of topical adenosine products in hair loss.
Ewelina Szendzielorz, Radoslaw Spiewak
doaj   +1 more source

Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]

FEBS Letters, 2009
Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Park, Jae, Singh, Bhag, Gupta, Radhey S.
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]

, 2011
Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam, Karpyak Victor M., Preuss Ulrich W., Peter Zill, Colin Colby, David A. Mrazek, Colby Colin, Biernacka Joanna M., Moonnoh R. Lee, Preuss, Ulrich W., Victor M. Karpyak, Lee, Moonnoh R., Kim, Jeong-Hyun, Kim Jeong-Hyun, Lee Moonnoh R., Zill, Peter, Jeong-Hyun Kim, Joanna M. Biernacka, Nam Hyung Wook, David A Mrazek, Gihyun Yoon, Moonnoh R Lee, Ulrich W. Preuss, Zill Peter, Colby, Colin, Doo-Sup Choi, Yoon, Gihyun, Joanna M Biernacka, Ulrich W Preuss, Mrazek, David A., Nam, Hyung Wook, Yoon Gihyun, Choi, Doo-Sup, Victor M Karpyak, Mrazek David A., Biernacka, Joanna M., Choi Doo-Sup, Karpyak, Victor M.   +37 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science
Although the intestinal clock (the circadian timing system in the gastrointestinal tract) is known to direct a wide variety of diurnal nutrients and metabolites, its role in the functioning of extra‐intestinal tissues such as the brain remains elusive ...
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
doaj   +1 more source

CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue

Frontiers in Immunology
Next to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute to ...
Michelle Y. Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren   +6 more
doaj   +1 more source

Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

Deletion of murine slc29a4 modifies vascular responses to adenosine and 5‐hydroxytryptamine in a sexually dimorphic manner

Physiological Reports, 2020
Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5‐hydroxytryptamine (5‐HT) and adenosine across cell membranes.
Ran Wei, Stephen L. Gust, David Tandio, Alexia Maheux, Khanh H. Nguyen, Joanne Wang, Stephane Bourque, Frances Plane, James R. Hammond   +8 more
doaj   +1 more source