Results 81 to 90 of about 475,417 (315)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Purinergic ecto-enzymes in human and ovine aortic valves: indicators of bacterial nanocellulose scaffold cellularization

Artificial Cells, Nanomedicine, and Biotechnology
Purinergic signalling pathways play a vital role in the biological functions of the aortic valve (AV) through nucleotide and adenosine-dependent receptor effects.
Barbara Kutryb-Zając, Ada Kawecka, Gabriela Harasim, Michał Bieńkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T. Smoleński, Maciej M. Kowalik, Magdalena Kołaczkowska, Piotr Siondalski   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]

, 2011
Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam, Karpyak Victor M., Preuss Ulrich W., Peter Zill, Colin Colby, David A. Mrazek, Colby Colin, Biernacka Joanna M., Moonnoh R. Lee, Preuss, Ulrich W., Victor M. Karpyak, Lee, Moonnoh R., Kim, Jeong-Hyun, Kim Jeong-Hyun, Lee Moonnoh R., Zill, Peter, Jeong-Hyun Kim, Joanna M. Biernacka, Nam Hyung Wook, David A Mrazek, Gihyun Yoon, Moonnoh R Lee, Ulrich W. Preuss, Zill Peter, Colby, Colin, Doo-Sup Choi, Yoon, Gihyun, Joanna M Biernacka, Ulrich W Preuss, Mrazek, David A., Nam, Hyung Wook, Yoon Gihyun, Choi, Doo-Sup, Victor M Karpyak, Mrazek David A., Biernacka, Joanna M., Choi Doo-Sup, Karpyak, Victor M.   +37 more
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]

, 2002
The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal [PDF]

, 2009
Human African trypanosomiasis (HAT) manifests as a chronic infection caused by <i>Trypanosoma brucei gambiense</i>, or as a more acute form due to <i>T. b. rhodesiense</i>.
Barbara Nerima, Pascal Mäser, Nerima, B., Barrett, M.P., Nerima, Barbara, de Koning Harry P., Matovu, E., Kazibwe, Anne J., Anne J N Kazibwe, Kazibwe Anne J. N., Enock Matovu, Kazibwe, A.J.N., Mäser, Pascal, De Koning, H.P., Matovu Enock, Harry P de Koning, Barrett Michael P., de Koning, Harry P., Barrett, Michael P., Michael P Barrett, Mäser, P., Mäser Pascal, Matovu, Enock, Nerima Barbara   +23 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source