Results 61 to 70 of about 16,538 (257)

METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246

Cell Death Discovery, 2021
Ovarian cancer is a common gynecological malignant tumor with a high mortality rate and poor prognosis. There is inadequate knowledge of the molecular mechanisms underlying ovarian cancer.
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang   +7 more
doaj   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase [PDF]

Methylation of adenine N6 (m6A) is the most frequent RNA modification. On mRNA, it is catalyzed by the METTL3-14 heterodimer complex which plays a key role in acute myeloid leukemia (AML) and other types of blood cancers and solid tumors.
Valeria, Romanucci, Francesco, Errani, Ivan, Corbeski, Amedeo, Caflisch, Annalisa, Invernizzi, Elena, Bochenkova, Fiona, Stamm, František, Zálešák, Giovanni, Di Fabio, Marcin, Herok   +9 more
core   +2 more sources

METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

Frontiers in Bioscience-Landmark
Background: Osteosarcoma cells are prone to metastasis, and the mechanism of N6-methyladenosine (m6A) methylation modification in this process is still unclear.
Xi-song Huo, Dan Lu, Da-gui Chen, Min Ye, Xiao-wei Wang, Fu-sheng Shang   +5 more
doaj   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

METTL3 knockout in U2OS cells also appears to be incomplete.

, 2022
(A) METTL3 KO U2OS cells have persistent m6A. METTL3 KO U2OS cells have been reported to have 60% the levels of m6A found in control U2OS cells [24]. We reconfirmed this with mass spectrometry measurements of m6A, which showed that METTL3 KO U2OS cells ...
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2

Open Medicine
We aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan, Ling Qipeng, Xu Jie, Ye Yunyao, Dong Lili   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells

Cell Death Discovery, 2022
Osteosarcoma (OS) is a prevalent primary bone sarcoma. Methyltransferase-like 3 (METTL3) is dysregulated in human malignancies. This study explored the mechanism of METTL3 in OS cell proliferation.
Renbing Jiang, Zhibing Dai, Junshen Wu, Suzhi Ji, Yachao Sun, Wenpeng Yang   +5 more
doaj   +1 more source

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m6A Dependent Manner

Frontiers in Oncology, 2021
Acquired chemoresistance is a major limiting factor in the clinical treatment of glioblastoma (GBM). However, the mechanism by which GBM acquires therapeutic resistance remains unclear.
Jia Shi, Jia Shi, Gang Chen, Xuchen Dong, Haoran Li, Suwen Li, Shan Cheng, Yongdong Li, Liping Wang, Jiaqi Yuan, Zhiyuan Qian, Jun Dong   +11 more
doaj   +1 more source