Results 61 to 70 of about 15,062 (245)

Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics

Open Life Sciences, 2023
N6-methyladenosine (m6A) is a representative of RNA methylation modification, which plays a critical role in the epigenetic modification process of regulating human diseases.
Liu Hanqi, Huang Yanqing, Lu Shanshan, Yuan Didi, Liu Junwen   +4 more
doaj   +1 more source

Expression and clinical significance of METTL3 in colorectal cancer

Medicine, 2023
Methyltransferase-like 3 (METTL3) belongs to the class I MTase family, and it has been proved that METTL3 is highly expressed in a variety of tumors and promotes tumor progression. Our previous studies have shown that METTL3 is highly expressed in gastric cancer tissues compared with para-cancer tissues, and its expression level is negatively ...
Hui Li, Zhilin Liu, Haitao Wang
openaire   +2 more sources

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

METTL3 contribution to cell proliferation in Thymic Epithelial Tumor Cells [PDF]

, 2022
Thymic epithelial tumors (TETs) are rare neoplasms, originated from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined and a deeper molecular characterization could result in a relevant advance in their ...
Andrea Sacconi, Giovanni Blandino, Silvia Masciarelli, Vincenzo Petrozza, Luciana De Angelis, Zaira Ianniello, Valentina Laquintana, Giulia Fontemaggi, Francesco Fazi, Federica Ganci, Francesco Facciolo, Enzo Gallo, Mirella Marino, Sara Aversa, Alessandro Fatica, Enrico Melis, Daniele Diso, Claudia Tito, Alessia Iaiza, Marco Anile, Edoardo Pescarmona, Federico Venuta   +21 more
core  

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis [PDF]

, 2022
A-to-I RNA editing and m6A modification are two of the most prevalent types of RNA modifications controlling gene expression in mammals and play very important roles in tumorigenesis and tumor progression.
Jia-Chu Li, Wang, Ning-Xi, Yin, Chuan, Sheng-Yong Yang, Li, Jia-Chu, Yi Li, Chuan Yin, Jiang, Shan-Shan, Yang, Sheng-Yong, Li, Yi, Ning-Xi Wang, Shan-Shan Jiang   +11 more
core   +1 more source

METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

Frontiers in Bioscience-Landmark
Background: Osteosarcoma cells are prone to metastasis, and the mechanism of N6-methyladenosine (m6A) methylation modification in this process is still unclear.
Xi-song Huo, Dan Lu, Da-gui Chen, Min Ye, Xiao-wei Wang, Fu-sheng Shang   +5 more
doaj   +1 more source

METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells

Cell Death Discovery, 2022
Osteosarcoma (OS) is a prevalent primary bone sarcoma. Methyltransferase-like 3 (METTL3) is dysregulated in human malignancies. This study explored the mechanism of METTL3 in OS cell proliferation.
Renbing Jiang, Zhibing Dai, Junshen Wu, Suzhi Ji, Yachao Sun, Wenpeng Yang   +5 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

METTL3 promotes the proliferation and mobility of gastric cancer cells [PDF]

, 2019
Methyltransferase-like 3 (METTL3) was originally known to be responsible for N6-methyladenosine (m6A) modification of mRNA. Recent studies have found that METTL3 plays important roles in a variety of tumors by regulating the translation of oncogenes ...
Chen Yuan, Wang Xuexiang, Sun Chao, Wang Peng, Lin Sen, Liu Jianing, Jiang Wen, Wang Hongbo   +7 more
core   +1 more source