Results 81 to 90 of about 15,062 (245)

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Cancer Cell International, 2022
Background N6-methyladenosine (m6A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear.
Yiming Xu, Dandan Lv, Chao Yan, Hua Su, Xue Zhang, Yangfeng Shi, Kejing Ying   +6 more
doaj   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases [PDF]

, 2023
N6-methyladenosine (m6A) modification, catalyzed by methyltransferase complexes (MTCs), plays many roles in multifaceted biological activities. As the most important subunit of MTCs, the METTL3-METTL14 complex is reported to be the initial factor that ...
Yeqiu Xu, Ming He, Yinzhou Luo, Guanzhen Qiu, Yong Wang, Yuanzhuang Zhang, Jie Lu   +6 more
core   +1 more source

METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer

Frontiers in Oncology, 2022
The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC.
Nuofan Wang, Xinying Huo, Baoguo Zhang, Xiaoxiang Chen, Shuli Zhao, Xuesong Shi, Hao Xu, Xiaowei Wei   +7 more
doaj   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis [PDF]

, 2018
N6-methyladenosine (m6A) modification of mRNA is emerging as an important regulator of gene expression that affects different developmental and biological processes, and altered m6A homeostasis is linked to cancer1-5.
Locker, Nicolas, Nicolas Locker, Gregory, Richard I., Frank J. Slack, Junho Choe, Kwok-Kin Wong, Kim, Wantae, Peng Du, Richards, William G., Wong, Kwok Kin, Choe, Junho, Tang, Sahojun, Slack, Frank J., Lin, Shuibin, Ramírez-Moya, Julia, Pilar Santisteban, Sliz, Piotr, Qi Liu, Richards, William G, Richard I. Gregory, Shuibin Lin, Wang, Longfei, Zhang, Wencai, Wong, Kwok-Kin, Wencai Zhang, Tang, Shaojun, Slack, Frank J, Julia Ramirez-Moya, Liu, Qi, Shaojun Tang, George, Rani E, Santisteban, Pilar, William G. Richards, Du, Peng, Longfei Wang, Gregory, Richard I, Piotr Sliz, Rani E. George, George, Rani E., Wantae Kim   +39 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

METTL3 affects the biological function of lung adenocarcinoma through the FGF2/PI3K/AKT /mTOR pathway

Frontiers in Oncology
IntroductionThis study aims to investigate the role of the m6A regulatory factor METTL3 in LUAD.MethodsBy examining the expression of METTL3 in LUAD and conducting cellular functional experiments, the biological functions of METTL3 were discussed.
Shaoting Chen, Shaoting Chen, Xiuqing Shen, Pengju Cao, Qianshun Chen, Rongxin Zhong, Yingping Cao   +6 more
doaj   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

METTL3 participates in m6A modification to regulate HBV replication through an IGF2BP2-dependent manner

陆军军医大学学报
Objective To investigate the molecular mechanism by which methytransferase like3 (METTL3) cooperates with insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) to regulate HBV replication through N6-methyladenosine (m6A) modifications.
YU Ling, ZHANG Zili, ZENG Rong
doaj   +1 more source