Results 81 to 90 of about 13,391 (192)

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2

Scientific Reports
N6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo, Yangyang Bai, Lu Wang, Zhen Xu, Nan Zhang, Wuliang Wang, Hu Zhao   +6 more
doaj   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

METTL3–m6A–STAT1/NF-κB axis: a key switch for the immunosuppressive capacity of mesenchymal stem cells

Cellular & Molecular Biology Letters
Background Owing to their immunosuppressive nature, mesenchymal stem cells (MSCs)—a type of multipotent stem cell—hold considerable promise for therapeutic applications.
Keke Tang, Hong Han, Ruizheng Sun, Yi Xu, Shengdi Zhang, Chen Lai, Yu Peng   +6 more
doaj   +1 more source

Fusion protein condensate formation via coiled‐coil domains

Protein Science, Volume 35, Issue 7, July 2026.
Abstract While recent research shows that biomolecular condensates play important roles in normal cellular processes and diseases, the driving forces in condensate formation are not well understood, especially regarding the role of structured self‐associative protein domains.
Om Prakash Narayan, Lu Liu, Kyle Scheller, Carter Humphrey, Jiawei Dong, Juan Guan   +5 more
wiley   +1 more source

The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury

Journal of Inflammation Research
Xuesong Xie,1 Fang Fang2 1Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China; 2Department of Anorectal, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of ChinaCorrespondence: Fang Fang ...
Xie X, Fang F
doaj  

StALKBH10B‐Mediated RNA m6A Modification Inhibits Potato Salt Tolerance by Targeting Flavonoids and ABA Signalling Pathways

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4435-4453, July 2026.
ABSTRACT N6‐methyladenosine (m6A) is the most prevalent methylation modification present in mRNAs, which has been confirmed to participate in many developmental and biological processes. However, the biological function and specific regulatory mechanism of m6A modification in relation to salt tolerance of potato remain obscure.
Xuanming Dong, Jianyu Ma, Chenxin Sui, Yan Li, Vadim Khassanov, Hongju Jian, Dianqiu Lv   +6 more
wiley   +1 more source

Disease‐Associated Remodeling of m6A RNA Methylation in Human Interstitial Cells From Fibro‐Calcific Aortic Valves

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Direct RNA sequencing of primary human valvular interstitial cells (VICs) from non‐calcified control and fibro‐calcific aortic stenosis (AS) valves reveals disease‐associated remodeling of m6A RNA methylation. AS‐derived VICs show an overall increase in detected m6A sites, together with transcript‐specific hyper‐ and hypo‐methylation patterns ...
Vincenza Valerio, Omar Molla, Ilaria Massaiu, Gloria Garoffolo, Veronika A. Myasoedova, Mattia Chiesa, Paolo Poggio   +6 more
wiley   +1 more source

Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

Frontiers in Immunology
Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 ...
Xiaoqing Guan, Fengyi Zhang, Ning Zhang, Guangchun Li, Fei Yin   +4 more
openaire   +3 more sources

METTL3 as a potential therapeutic target in gastric cancer

Frontiers in Oncology
Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. N6-methyladenosine (m6A) modification is the most prominent epigenetic modification of eukaryotic mRNAs, and methyltransferase-like 3 (METTL3), a core component of the methyltransferase complex, catalyzes m6A modification.
Zhefei Yu, Yang Yang
openaire   +3 more sources