Results 81 to 90 of about 16,538 (257)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

METTL3 participates in m6A modification to regulate HBV replication through an IGF2BP2-dependent manner

陆军军医大学学报
Objective To investigate the molecular mechanism by which methytransferase like3 (METTL3) cooperates with insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) to regulate HBV replication through N6-methyladenosine (m6A) modifications.
YU Ling, ZHANG Zili, ZENG Rong
doaj   +1 more source

METTL3 affects the biological function of lung adenocarcinoma through the FGF2/PI3K/AKT /mTOR pathway

Frontiers in Oncology
IntroductionThis study aims to investigate the role of the m6A regulatory factor METTL3 in LUAD.MethodsBy examining the expression of METTL3 in LUAD and conducting cellular functional experiments, the biological functions of METTL3 were discussed.
Shaoting Chen, Shaoting Chen, Xiuqing Shen, Pengju Cao, Qianshun Chen, Rongxin Zhong, Yingping Cao   +6 more
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

O-GlcNAcylation with ubiquitination stabilizes METTL3 to promoting HMGB1 degradation to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer

Molecular Medicine
Background Pancreatic cancer is highly lethal, and METTL3 plays a crucial role in the regulation of m6A. However, the therapeutic potential of METTL3 in pancreatic cancer is unclear.
Qiuhong Wang, Dong Wei, Chunman Li, Xiawei Yang, Kun Su, Tao Wang, Renchao Zou, Lianmin Wang, Dongyun Cun, Bo Tang, Tao Wu   +10 more
doaj   +1 more source

METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma

Cancer Medicine, 2020
METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma
Ye Lin, Xiangling Wei, Zhixiang Jian, Xuewen Zhang   +3 more
doaj   +1 more source

miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3

Open Medicine, 2022
This study was conducted to investigate the effect of microRNA-212-5p (miR-212-5p) on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells.
Zhou Hongyu, Zhang Nana
doaj   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis [PDF]

, 2018
N6-methyladenosine (m6A) modification of mRNA is emerging as an important regulator of gene expression that affects different developmental and biological processes, and altered m6A homeostasis is linked to cancer1-5.
Locker, Nicolas, Nicolas Locker, Gregory, Richard I., Frank J. Slack, Junho Choe, Kwok-Kin Wong, Kim, Wantae, Peng Du, Richards, William G., Wong, Kwok Kin, Choe, Junho, Tang, Sahojun, Slack, Frank J., Lin, Shuibin, Ramírez-Moya, Julia, Pilar Santisteban, Sliz, Piotr, Qi Liu, Richards, William G, Richard I. Gregory, Shuibin Lin, Wang, Longfei, Zhang, Wencai, Wong, Kwok-Kin, Wencai Zhang, Tang, Shaojun, Slack, Frank J, Julia Ramirez-Moya, Liu, Qi, Shaojun Tang, George, Rani E, Santisteban, Pilar, William G. Richards, Du, Peng, Longfei Wang, Gregory, Richard I, Piotr Sliz, Rani E. George, George, Rani E., Wantae Kim   +39 more
core   +1 more source