Results 71 to 80 of about 16,538 (257)

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

METTL3-Mediated mA Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling

Cell Transplantation, 2022
Accumulating data show that N6-methyladenosine (m 6 A) methyltransferase METTL3 and long noncoding RNA MALAT1 act pivotal roles in multiple malignancies including prostate cancer (PCa). However, the role and molecular mechanism underlying METTL3-mediated
Yuanshen Mao, Wenfeng Li, YiMing Weng, Bao Hua, Xin Gu, Chao Lu, Bin Xu, Huan Xu, Zhong Wang   +8 more
doaj   +1 more source

Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Cell Reports, 2023
Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear.
Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang   +15 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

METTL3-deficient macrophage enhances the phagocytosis of Aβ.

, 2023
(A) Representative fluorescence micrographs and quantitative analysis of brains from Aβ-induced mice transferred with WT and KO BM. (B) Representative fluorescence micrographs and quantitative analysis of brain from Aβ-induced mice transferred with WT ...
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer

Biomarker Research, 2023
Background N6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the regulation of the immune response to tumors.
Lei Zhan, Jing Zhang, Jun-Hui Zhang, Xiao-Jing Liu, Bao Guo, Jia-Hua Chen, Zhen-Hai Tang, Wen-Yan Wang, Qing-Yuan Wang, Bing Wei, Yun-Xia Cao   +10 more
doaj   +1 more source

METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer

Frontiers in Oncology, 2022
The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC.
Nuofan Wang, Xinying Huo, Baoguo Zhang, Xiaoxiang Chen, Shuli Zhao, Xuesong Shi, Hao Xu, Xiaowei Wei   +7 more
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

METTL3-deficiency enhances the migration of macrophage.

, 2023
(A) Flow cytometry analysis of brains from Aβ-induced mice transferred with WT and KO BM. (B) Flow cytometry analysis of brains from Aβ-induced mice (CD45.1) transferred with WT or KO monocytes (CD45.2).
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m6A modification

Cancer Cell International, 2022
Background N6-methyladenosine (m6A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear.
Yiming Xu, Dandan Lv, Chao Yan, Hua Su, Xue Zhang, Yangfeng Shi, Kejing Ying   +6 more
doaj   +1 more source