Results 71 to 80 of about 17,358 (223)
Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]
, 2019 N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng +6 more
core
Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]
, 2019 N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA +3 more
core +2 more sources
Programmable RNA N6,2´‐O‐Dimethyladenosine Editing
Advanced Science, EarlyView.ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li +9 more
wiley +1 more source
Cancer Medicine, 2020 METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma
Ye Lin +3 more
doaj +1 more source
Role of FTO in adipocyte development and function: recent insights [PDF]
, 2015 In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association.
Merkestein, Myrte, Sellayah, Dyan
core +2 more sources
Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants
Advanced Science, EarlyView.The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley +1 more source
METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4
Frontiers in Bioscience-LandmarkBackground: Osteosarcoma cells are prone to metastasis, and the mechanism of N6-methyladenosine (m6A) methylation modification in this process is still unclear.
Xi-song Huo +5 more
doaj +1 more source
A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation [PDF]
, 2014 Cells respond to environmental stressors and xenobiotic exposures using regulatory networks to control gene expression, and there is an emerging appreciation for the role of numerous postsynthetic chemical modifications of DNA, RNA, and proteins in ...
Begley, Thomas J., Dedon, Peter C
core +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
Open MedicineWe aimed to explore the regulatory effects of methyltransferase-like 3 (METTL3) on diabetic retinopathy (DR) by regulating the m6A modification of SOX2 mRNA and elucidating the underlying molecular mechanism.
Chen Xiujuan +4 more
doaj +1 more source