Results 51 to 60 of about 16,538 (257)

METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

Journal of Experimental & Clinical Cancer Research, 2022
Background Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) play key roles in cancer ...
Jiashu Pan, Feng Liu, Xiaoli Xiao, Ruohui Xu, Liang Dai, Mingzhe Zhu, Hanchen Xu, Yangxian Xu, Aiguang Zhao, Wenjun Zhou, Yanqi Dang, Guang Ji   +11 more
doaj   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

METTL3 enhances ATAT1-mediated microtubule acetylation.

, 2023
(A) Western blotting showing the level of α-tubulin acetylation in WT and KO BMDMs. (B) Immunoblotting analysis of the indicated proteins in the BMDMs transfected with NC siRNA or Mettl3 siRNA.
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

METTL3 Gains R/W Access to the Epitranscriptome [PDF]

Molecular Cell, 2016
Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.
Ulrike, Schumann, Andrew, Shafik, Thomas, Preiss   +2 more
openaire   +2 more sources

Expression and clinical significance of METTL3 in colorectal cancer

Medicine, 2023
Methyltransferase-like 3 (METTL3) belongs to the class I MTase family, and it has been proved that METTL3 is highly expressed in a variety of tumors and promotes tumor progression. Our previous studies have shown that METTL3 is highly expressed in gastric cancer tissues compared with para-cancer tissues, and its expression level is negatively ...
Hui Li, Zhilin Liu, Haitao Wang
openaire   +2 more sources

METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC

Open Medicine
Overexpression of methyltransferase-like 3 (METTL3) is significantly correlated with the malignancy of lung cancer (LC). In the present study, we demonstrated that METTL3 had higher levels in LC tissues relative to normal tissues.
Zhang Peng, Wang Su, Chen Yuanyuan, Yang Qingbo, Zhou Jian, Zang Wangfu   +5 more
doaj   +1 more source

Research Progress on Methyltransferase-like Protein 3 in Progression of Aerobic Glycolysis in Gastrointestinal Tumors

Zhongliu Fangzhi Yanjiu
Metabolic reprogramming is one of the significant characteristics of malignant tumor development. It provides the tumor with sufficient energy and materials. During the process by which tumor cells acquire metabolic reprogramming, epigenetic changes play
Deyuan MA, Na WANG, Huiqiang WANG, Quanlin GUAN   +3 more
doaj   +1 more source

METTL3 modulates m6A modification of CDC25B and promotes head and neck squamous cell carcinoma malignant progression

Experimental Hematology & Oncology, 2022
Background N6-methyladenosine (m6A) RNA methylation and its methyltransferase METTL3 have been widely reported to be involved in different cancers by regulating RNA metabolism and function.
Yu-qing Guo, Qiang Wang, Jun-guo Wang, Ya-jun Gu, Pan-pan Song, Shou-yu Wang, Xiao-yun Qian, Xia Gao   +7 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Critical Roles of METTL3 in Translation Regulation of Cancer

Biomolecules, 2023
Aberrant translation, a characteristic feature of cancer, is regulated by the complex and sophisticated RNA binding proteins (RBPs) in the canonical translation machinery. N6-methyladenosine (m6A) modifications are the most abundant internal modifications in mRNAs mediated by methyltransferase-like 3 (METTL3). METTL3 is commonly aberrantly expressed in
Wangyang Meng, Han Xiao, Peiyuan Mei, Jiaping Chen, Yangwei Wang, Rong Zhao, Yongde Liao   +6 more
openaire   +3 more sources