Results 51 to 60 of about 17,358 (223)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
Open MedicineOverexpression of methyltransferase-like 3 (METTL3) is significantly correlated with the malignancy of lung cancer (LC). In the present study, we demonstrated that METTL3 had higher levels in LC tissues relative to normal tissues.
Zhang Peng +5 more
doaj +1 more source
M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis
Frontiers in Bioscience-LandmarkBackground: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis.
Fei Qin +5 more
doaj +1 more source
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. [PDF]
, 2019 Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress.
Chen, Xuemei +5 more
core +1 more source
Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma [PDF]
, 2017 Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Solar UV radiation is the major factor in the etiology of cSCC. Wholeexome sequencing of 18 microdissected tumor samples (cases) derived from SKH-1
Aikseng Ooi +16 more
core +2 more sources
THE ROLE OF THE M6A METHYLTRANSFERASE METTL3 IN AN IN VITRO MODEL OF ANTIGEN-SELECTED GERMINAL CENTER B CELLS [PDF]
, 2021 N6-methyladenosine (m6A) represents the most abundant modification introduced into messenger RNA. In mammals, m6A regulates gene expression by controlling different facets of mRNA metabolism including splicing, translation and stability.
GRECO, FEDERICA
core +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Leukemia, 2023 Recent efforts in understanding the epitranscriptome have shown that a diverse set of modifications to RNA represent a new pervasive mechanism of gene regulation, with roles in stem cell homeostasis and disease. N6-methyladenosine (m6A) is an evolutionarily conserved RNA modification and one of the most abundant found on polyadenylated RNA(1,2).
Sturgess, Katherine +15 more
openaire +4 more sources
Cancer Management and Research, 2020 Tian-Liang Xia,* Shu-Mei Yan,* Li Yuan, Mu-Sheng Zeng State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China*These authors ...
Xia TL, Yan SM, Yuan L, Zeng MS
doaj
Down-regulation of METTL3-LYN m6A-IGF2BP2 pathway inhibits endothelial cell migration
Di-san junyi daxue xuebao, 2021 Objective To investigate the effect of methyltransferase like 3 (METTL3) on the migration of human umbilical vein endothelial cells (HUVECs), and explore the underlying mechanism preliminarily.
BAI Qin +4 more
doaj +1 more source