Results 51 to 60 of about 15,062 (245)

METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

Epigenetics, 2023
Doxorubicin (DOX) resistance in breast cancer (BC) poses a huge challenge for the therapeutic effect on BC. Lnc KCNQ1OT1 play crucial roles in chemotherapy resistance.
Zhiyang Zhou, Yukun Cao, Yuan Yang, Shouman Wang, Feiyu Chen   +4 more
doaj   +1 more source

M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis

Frontiers in Bioscience-Landmark
Background: Traumatic brain injury (TBI) is a disease caused by external forces that damage brain structure and function. After TBI, iron accumulation and reactive oxygen species (ROS) increase lipid peroxidation, promoting ferroptosis.
Fei Qin, Fan Li, Wenxiao Zhao, Suqin Zhang, Jiang Shen, Xinyu Yang   +5 more
doaj   +1 more source

Critical Roles of METTL3 in Translation Regulation of Cancer

Biomolecules, 2023
Aberrant translation, a characteristic feature of cancer, is regulated by the complex and sophisticated RNA binding proteins (RBPs) in the canonical translation machinery. N6-methyladenosine (m6A) modifications are the most abundant internal modifications in mRNAs mediated by methyltransferase-like 3 (METTL3). METTL3 is commonly aberrantly expressed in
Wangyang Meng, Han Xiao, Peiyuan Mei, Jiaping Chen, Yangwei Wang, Rong Zhao, Yongde Liao   +6 more
openaire   +3 more sources

Upregulation of METTL3 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Cancer Management and Research, 2020
Tian-Liang Xia,* Shu-Mei Yan,* Li Yuan, Mu-Sheng Zeng State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China*These authors ...
Xia TL, Yan SM, Yuan L, Zeng MS
doaj  

METTL3 Gains R/W Access to the Epitranscriptome [PDF]

Molecular Cell, 2016
Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.
Ulrike, Schumann, Andrew, Shafik, Thomas, Preiss   +2 more
openaire   +2 more sources

Self-interaction of METTL3 provides multivalency for LLPS of the writer complex. [PDF]

, 2022
(A) Representative images showing localization of EGFP control, EGFP-METTL14 or EGFP-WTAP after Cry2-mCh-METTL3 condensates formation by light stimulation. Scale bar = 10 μm.
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase [PDF]

Methylation of adenine N6 (m6A) is the most frequent RNA modification. On mRNA, it is catalyzed by the METTL3-14 heterodimer complex which plays a key role in acute myeloid leukemia (AML) and other types of blood cancers and solid tumors.
Valeria, Romanucci, Francesco, Errani, Ivan, Corbeski, Amedeo, Caflisch, Annalisa, Invernizzi, Elena, Bochenkova, Fiona, Stamm, František, Zálešák, Giovanni, Di Fabio, Marcin, Herok   +9 more
core   +1 more source

METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC

Open Medicine
Overexpression of methyltransferase-like 3 (METTL3) is significantly correlated with the malignancy of lung cancer (LC). In the present study, we demonstrated that METTL3 had higher levels in LC tissues relative to normal tissues.
Zhang Peng, Wang Su, Chen Yuanyuan, Yang Qingbo, Zhou Jian, Zang Wangfu   +5 more
doaj   +1 more source

Research Progress on Methyltransferase-like Protein 3 in Progression of Aerobic Glycolysis in Gastrointestinal Tumors

Zhongliu Fangzhi Yanjiu
Metabolic reprogramming is one of the significant characteristics of malignant tumor development. It provides the tumor with sufficient energy and materials. During the process by which tumor cells acquire metabolic reprogramming, epigenetic changes play
Deyuan MA, Na WANG, Huiqiang WANG, Quanlin GUAN   +3 more
doaj   +1 more source