Results 31 to 40 of about 16,538 (257)

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. [PDF]

, 2021
Recent evidence has highlighted the role of N 6-methyladenosine (m6A) in the regulation of mRNA expression, stability, and translation, supporting a potential role for posttranscriptional regulation mediated by m6A in cancer.
Cotter, Kellie A, Meyer, Kate D., Meyer, Kate D, Cotter, Kellie A., Jaffrey, Samie R., Rubin, Mark A., Jaffrey, Samie R, Gallon, John, Piscuoglio, Salvatore, Uebersax, Nadine, Rubin, Mark A, Rubin, Philip   +11 more
core   +2 more sources

Mining for METTL3 inhibitors to suppress cancer

Nature Structural & Molecular Biology, 2021
The RNA methyltransferase METTL3 catalyzes N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of METTL3 shows significant antileukemic effects in preclinical
Jiazhi Li, Richard I. Gregory
openaire   +3 more sources

METTL3-mediated mA modification of lncRNA SNHG3 accelerates gastric cancer progression by modulating miR-186-5p/cyclinD2 axis

International Journal of Immunopathology and Pharmacology, 2023
Objectives METTL3 as an m 6 A methyltransferase acts in diverse malignancies including gastric cancer (GC). We aimed to reveal the underlying mechanisms by which METTL3 contributes to gastric carcinogenesis.
Guo Ji, Xiu Wang, Hao Xi
doaj   +1 more source

METTL3 regulates exocytosis independently of m⁶A. [PDF]

Sci Adv
RNA modification pathways are often misregulated in various cancers, with N6-methyladenosine (m6A) having a pivotal role in cancer progression and metastasis.
Esteva-Socias M, Bhattarai DP, Achour C, Baidya P, Kumari K, Fontanari G, Seier K, Pace H, Malla S, Zhu S, Lundin E, Vågbø CB, Bally M, Swaminathan V, Mateus A, Rodriguez-Barrueco R, Pich A, Aguilo F.   +17 more
europepmc   +2 more sources

METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation

, 2022
Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. Old C57BL/6J mice were injected with the silencing lentivirus of MIR99AHG and subjected
Jianning Zhao (795284), Hao Ding (186871), Yicun Wang (1612309), Beiyue Wang (14108852), Chang Sun (238617), Lintao Li (753372), Xing Zhou (469137), Fan Zhang (46132)   +7 more
core   +1 more source

METTL3-mediated m⁶A is required for murine oocyte maturation and maternal-to-zygotic transition

, 2020
N6-methyladenosine (m6A) is the most prevalent epigenetic modification of messenger RNA (mRNA) in higher eukaryotes; this modification is mainly catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as a key factor ...
Qiqi Cao (6249212), Yue Hu (201714), Shuai Zhou (331138), Xuesong Sui (840351), Yumeng Cao (8273763), Wenjie Shu (15901), Chao Ren (286724), Mingrui Li (2567635), Ran Huo (165404)   +8 more
core   +1 more source

Polysome profiling reveals that exon2 Mettl3 KO mESCs translate Mettl3 mRNAs.

, 2022
To investigate if the altered Mettl3 mRNAs expressed in the exon2 Mettl3 KO mESCs are translated, we performed polysome profiling. The polysomes were separated into 4 fractions based on their ribosome load: Fraction 1 (sub-monosomal), Fraction 2 (low ...
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

Analysis of METTL3 and METTL14 in hepatocellular carcinoma

Aging, 2020
N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of messenger RNAs (mRNAs) and catalyzed by a multicomponent methyltransferase complex (MTC), among which methyltransferase-like 3 (METTL3) and METTL14 are two core molecules. However, METTL3 and METTL14 play opposite regulatory roles in hepatocellular carcinoma (HCC).
Liu, Xiangxiang, Qin, Jian, Gao, Tianyi, Li, Chenmeng, Chen, Xiaoxiang, Zeng, Kaixuan, Xu, Mu, He, Bangshun, Pan, Bei, Xu, Xueni, Pan, Yuqin, Sun, Huiling, Xu, Tao, Wang, Shukui   +13 more
openaire   +2 more sources

Shortened isoforms of METTL3 catalyze m⁶A formation in Mettl3 KO mESCs.

, 2022
(A) The predicted domain structure of proteins encoded by the altered METTL3 ORFs expressed in exon2 Mettl3 KO mESCs suggests they may be functional. The domains that are known to be necessary for m6A formation by METTL3 include the WTAP-binding domain ...
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages. [PDF]

, 2023
Recent efforts in understanding the epitranscriptome have shown that a diverse set of modifications to RNA represent a new pervasive mechanism of gene regulation, with roles in stem cell homeostasis and disease.

core   +10 more sources