Results 31 to 40 of about 17,358 (223)

Defining the genomic signature of the parous breast. [PDF]

, 2012
: BACKGROUND: It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity.
Afanasyeva, Y., Ahman, J., Arslan, A.A., Belitskaya-Lévy, I., Bordas, P., de Cicco, R.L., Hallmans, G., Johansson, R., Lenner, P., Peri, S., Ross, E.A., Russo, I.H., Russo, J., Russo, P.A., Santucci-Pereira, J., Sheriff, F., Slifker, M., Toniolo, P., Zeleniuch-Jacquotte, A.   +18 more
core   +2 more sources

METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells

Cell Death Discovery, 2022
Osteosarcoma (OS) is a prevalent primary bone sarcoma. Methyltransferase-like 3 (METTL3) is dysregulated in human malignancies. This study explored the mechanism of METTL3 in OS cell proliferation.
Renbing Jiang, Zhibing Dai, Junshen Wu, Suzhi Ji, Yachao Sun, Wenpeng Yang   +5 more
doaj   +1 more source

Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core   +1 more source

METTL3-Mediated mA Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling

Cell Transplantation, 2022
Accumulating data show that N6-methyladenosine (m 6 A) methyltransferase METTL3 and long noncoding RNA MALAT1 act pivotal roles in multiple malignancies including prostate cancer (PCa). However, the role and molecular mechanism underlying METTL3-mediated
Yuanshen Mao, Wenfeng Li, YiMing Weng, Bao Hua, Xin Gu, Chao Lu, Bin Xu, Huan Xu, Zhong Wang   +8 more
doaj   +1 more source

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker, B Moindrot, C Church, C Schütt, C Trapnell, CF Hongay, D Dominissini, D Kim, D Sturgill, D Yan, DP Patil, E Zaharieva, Eugenio Sanchez-Moran, GZ Luo, Helen K. Salz, Irmgard U. Haussmann, IU Haussmann, IU Haussmann, IU Haussmann, J Liu, J Zhou, JA Bokar, JE Harper, JT Robinson, K Horiuchi, KD Meyer, KD Meyer, KJ Livak, LO Penalva, M Niessen, M Soller, M Soller, M Soller, Matthias Soller, Nathan Archer, Nigel P. Mongan, RP Perry, Rupert G. Fray, S Geula, S Ke, S Luo, S Schwartz, S Zhong, SR Starck, W Xiao, X Wang, Z Bodi, Z Bodi, Zsuzsanna Bodi   +48 more
core   +5 more sources

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer

Biomarker Research, 2023
Background N6-methyladenosine (m6A) methylation is the most abundant chemical posttranscriptional modification of mRNA, and it is associated with the regulation of the immune response to tumors.
Lei Zhan, Jing Zhang, Jun-Hui Zhang, Xiao-Jing Liu, Bao Guo, Jia-Hua Chen, Zhen-Hai Tang, Wen-Yan Wang, Qing-Yuan Wang, Bing Wei, Yun-Xia Cao   +10 more
doaj   +1 more source

METTL3 Gains R/W Access to the Epitranscriptome [PDF]

Molecular Cell, 2016
Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.
Ulrike, Schumann, Andrew, Shafik, Thomas, Preiss   +2 more
openaire   +2 more sources

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m6A Dependent Manner

Frontiers in Oncology, 2021
Acquired chemoresistance is a major limiting factor in the clinical treatment of glioblastoma (GBM). However, the mechanism by which GBM acquires therapeutic resistance remains unclear.
Jia Shi, Jia Shi, Gang Chen, Xuchen Dong, Haoran Li, Suwen Li, Shan Cheng, Yongdong Li, Liping Wang, Jiaqi Yuan, Zhiyuan Qian, Jun Dong   +11 more
doaj   +1 more source

Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants [PDF]

, 2016
13 p.-1 fig.Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs.
Del Mazo, Jesús, Larriba, E.
core   +2 more sources

Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Cell Reports, 2023
Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear.
Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang   +15 more
doaj   +1 more source