Results 31 to 40 of about 15,062 (245)

METTL3-deficiency enhances the migration of macrophage. [PDF]

, 2023
(A) Flow cytometry analysis of brains from Aβ-induced mice transferred with WT and KO BM. (B) Flow cytometry analysis of brains from Aβ-induced mice (CD45.1) transferred with WT or KO monocytes (CD45.2).
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. [PDF]

, 2021
Recent evidence has highlighted the role of N 6-methyladenosine (m6A) in the regulation of mRNA expression, stability, and translation, supporting a potential role for posttranscriptional regulation mediated by m6A in cancer.
Cotter, Kellie A, Meyer, Kate D., Meyer, Kate D, Cotter, Kellie A., Jaffrey, Samie R., Rubin, Mark A., Jaffrey, Samie R, Gallon, John, Piscuoglio, Salvatore, Uebersax, Nadine, Rubin, Mark A, Rubin, Philip   +11 more
core   +1 more source

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Cancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu   +6 more
doaj   +1 more source

METTL3/m6A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma

Frontiers in Pharmacology, 2022
Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m6A, is essential for controlling mRNA stability, splicing, and translation.
Fangfang Ge, Fangfang Ge, Zhenyu Li, Zhenyu Li, Jiaru Hu, Youguang Pu, Fangfang Zhao, Lingsuo Kong   +7 more
doaj   +1 more source

Conditional METTL3 knockouts can be used to study m⁶A when stable METTL3 knockouts are not viable. [PDF]

, 2022
(A) Most cell lines are dependent on METTL3 for growth. Mouse studies previously indicated that Mettl3 is an essential gene for early embryonic survival [5], so we wanted to know which cell lines are dependent on METTL3.
Hui Xian Poh (13118985), Samie R. Jaffrey (1306116), Aashiq H. Mirza (7543664), Brian F. Pickering (13118988)   +3 more
core   +1 more source

Mining for METTL3 inhibitors to suppress cancer

Nature Structural & Molecular Biology, 2021
The RNA methyltransferase METTL3 catalyzes N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of METTL3 shows significant antileukemic effects in preclinical
Jiazhi Li, Richard I. Gregory
openaire   +3 more sources

METTL3 enhances ATAT1-mediated microtubule acetylation. [PDF]

, 2023
(A) Western blotting showing the level of α-tubulin acetylation in WT and KO BMDMs. (B) Immunoblotting analysis of the indicated proteins in the BMDMs transfected with NC siRNA or Mettl3 siRNA.
Xiang Zhang (19800), Zhuan Ju (14755548), Xiaofang Zhang (181594), Wenjie Zuo (11050641), Jiadi Li (12914183), Huilong Yin (14755545), Yidi Wang (3079407), Xiaochen Ding (6841085), Yingran Peng (14755551), Rui Zhang (13940), Minhua Zheng (232421), Angang Yang (250347)   +11 more
core   +1 more source

The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma

Journal of Translational Medicine, 2022
Background As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers.
Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng, Jingting Jiang   +7 more
doaj   +1 more source

METTL3-mediated mA modification of lncRNA SNHG3 accelerates gastric cancer progression by modulating miR-186-5p/cyclinD2 axis

International Journal of Immunopathology and Pharmacology, 2023
Objectives METTL3 as an m 6 A methyltransferase acts in diverse malignancies including gastric cancer (GC). We aimed to reveal the underlying mechanisms by which METTL3 contributes to gastric carcinogenesis.
Guo Ji, Xiu Wang, Hao Xi
doaj   +1 more source

METTL3-mediated m⁶A modification is required for cerebellar development [PDF]

, 2018
N6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs and plays important roles in various biological processes. The formation of m6A is catalyzed by a methyltransferase complex including methyltransferase-like 3 (METTL3) as
Wei Li (7081), Hai-Lin Wang, Guan-Shen Cui (5349773), Chen-Xin Wang (5349779), Ang Li (110963), Bao-Fa Sun (257565), Xiu-Jie Wang, Xin-Xin Zhang (359043), Wei-Min Tong (119899), Li-Yuan Jiang (4632328), Yun-Gui Yang (119905), Ying Yang (24175), Wei Li, Chen-Xin Wang, Qi Zhou (7408), Xiu-Jie Wang (4830), Wei-Min Tong, Xiuying Liu (137554), Kai Xu (122914), Hai-Lin Wang (4476319), Guan-Shen Cui, Yun-Gui Yang, Kai Xu, Wei-Yi Lai, Ang Li, Qi Zhou, Gui-Bin Jiang (806959), Xiuying Liu, Bao-Fa Sun, Li-Yuan Jiang, Meng Wang (124646), Meng Wang, Xin-Xin Zhang, Gui-Bin Jiang, Wei-Yi Lai (5349776), Ying Yang   +35 more
core   +1 more source