Results 1 to 10 of about 64,675 (164)
Methyltransferases of Riboviria
Biomolecules, 2022 Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
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Light‐Activation of DNA‐Methyltransferases [PDF]
Angewandte Chemie - International Edition, 2021 Abstract5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis.
Julian Kanne +2 more
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Methyltransferases: Functions and Applications
ChemBioChem, 2022 AbstractIn this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in
Helen Hailes +2 more
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On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2
PLoS ONE, 2011 The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA ...
Albert Jeltsch, Tomasz Jurkowski
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The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
Frontiers in Pharmacology, 2022 Methylation can occur in both histones and non-histones. Key lysine and arginine methyltransferases under investigation for renal disease treatment include enhancer of zeste homolog 2 (EZH2), G9a, disruptor of telomeric silencing 1-like protein (DOT1L ...
Xun Zhou +6 more
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Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. [PDF]
PLoS ONE, 2016 Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs).
Rajnee Kanwal +3 more
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Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved catabolic process induced under various stress conditions to protect the cell from harm and allow survival in the face of nutrient- or energy-deficient states.
Yin Shi +4 more
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Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2021 The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang +3 more
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Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes
Biomolecules, 2020 The C5-methylation of uracil to form 5-methyluracil (m5U) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions.
Pascal Sirand-Pugnet +9 more
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Journal of Fungi, 2023 Putative methyltranferase LaeA and LaeA-like proteins, conserved in many filamentous fungi, regulate fungal growth, development, virulence, the biosynthesis of secondary metabolites, and the production of cellulolytic enzymes.
Zhongjiao Liu +4 more
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