DNA methylation and DNA methyltransferases [PDF]
Epigenetics & Chromatin, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
core +4 more sources
Biological functions of m6A methyltransferases
Cell & Bioscience, 2021 M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m6A methyltransferases and explain ...
Jianzhong Gu +13 more
doaj +2 more sources
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
Journal of Hematology & Oncology, 2021 N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs.
Wei Huang +5 more
doaj +2 more sources
Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases. [PDF]
PLoS ONE, 2016 Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs).
Rajnee Kanwal +3 more
doaj +2 more sources
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]
, 2013 Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva +9 more
core +15 more sources
5-methylcytosine RNA methyltransferases and their potential roles in cancer
Journal of Translational Medicine, 2022 In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs.
Mingyang Li +6 more
semanticscholar +1 more source
Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved catabolic process induced under various stress conditions to protect the cell from harm and allow survival in the face of nutrient- or energy-deficient states.
Yin Shi +4 more
doaj +1 more source
Protein arginine methyltransferases: promising targets for cancer therapy
Experimental and Molecular Medicine, 2021 Protein methylation, a post-translational modification (PTM), is observed in a wide variety of cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic research, the importance of protein methylation has been ...
J. Hwang +4 more
semanticscholar +1 more source
Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2021 The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang +3 more
doaj +1 more source
Methyltransferases: Functions and Applications
ChemBioChem, 2022 In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed ...
Eman M M Abdelraheem +11 more
semanticscholar +1 more source