Results 21 to 30 of about 64,774 (259)

Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

BMC Medicine, 2011
Soft tissue sarcomas of childhood are a group of heterogeneous tumors thought to be derived from mesenchymal stem cells. Surgical resection is effective only in about 50% of cases and resistance to conventional chemotherapy is often responsible for ...
Giordano Antonio, Miele Lucio, Ciarapica Roberta, Locatelli Franco, Rota Rossella   +4 more
doaj   +1 more source

Methyltransferases of gentamicin biosynthesis [PDF]

Proceedings of the National Academy of Sciences, 2018
Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or
Sicong Li, Junhong Guo, Anna Reva, Fanglu Huang, Binbin Xiong, Yuanzhen Liu, Zixin Deng, Peter F. Leadlay, Yuhui Sun   +8 more
openaire   +2 more sources

Melatonin-Mediated Development of Ovine Cumulus Cells, Perhaps by Regulation of DNA Methylation

Molecules, 2018
Cumulus cells of pre-pubertal domestic animals are dysfunctional, perhaps due to age-specific epigenetic events. This study was designed to determine effects of melatonin treatment of donors on methylation modification of pre-pubertal cumulus cells ...
Yi Fang, Shoulong Deng, Jinlong Zhang, Haijun Liu, Yihai Li, Xiaosheng Zhang, Yixun Liu   +6 more
doaj   +1 more source

Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases

Molecules, 2022
In plants, methylation is a common step in specialized metabolic pathways, leading to a vast diversity of natural products. The methylation of these small molecules is catalyzed by S-adenosyl-l-methionine (SAM)-dependent methyltransferases, which are ...
Audrey Lashley, Ryan Miller, Stephanie Provenzano, Sara-Alexis Jarecki, Paul Erba, Vonny Salim   +5 more
doaj   +1 more source

Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’-O-Methylation of Viral RNA

Viruses, 2020
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2′-O-methyltransferase (2′-O-MTase) capping machinery to camouflage its RNA from innate immune recognition.
José Antonio Encinar, Javier A. Menendez   +1 more
doaj   +1 more source

Heterologous and High Production of Ergothioneine in Bacillus licheniformis by Using Genes from Anaerobic Bacteria

Metabolites
Purpose: This study aimed to utilize genetically engineered Bacillus licheniformis for the production of ergothioneine (EGT). Given the value of EGT and the application of Bacillus licheniformis in enzyme preparation production, we cloned the key enzymes
Zhe Liu, Fengxu Xiao, Yupeng Zhang, Jiawei Lu, Youran Li, Guiyang Shi   +5 more
doaj   +1 more source

Biological functions of m6A methyltransferases

Cell & Bioscience, 2021
M6A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m6A methyltransferases and explain ...
Jianzhong Gu, Yu Zhan, Lvjia Zhuo, Qin Zhang, Guohua Li, Qiujie Li, Shasha Qi, Jinyu Zhu, Qun Lv, Yingying Shen, Yong Guo, Shuiping Liu, Tian Xie, Xinbing Sui   +13 more
doaj   +1 more source

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Frontiers in Drug Discovery
Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases.
O. A. Arosarena, O. A. Arosarena, O. A. Arosarena, A. S. Saribas, E. P. Papadopoulos   +4 more
doaj   +1 more source

Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis

Molecules, 2016
We describe the characterisation of the O-methyltransferase JerF from the late stages of jerangolid biosynthesis. JerF is the first known example of an enzyme that catalyses the formation of a non-aromatic, cyclic methylenolether.
Steffen Friedrich, Franziska Hemmerling, Frederick Lindner, Anna Warnke, Johannes Wunderlich, Gesche Berkhan, Frank Hahn   +6 more
doaj   +1 more source

Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms

Frontiers in Cell and Developmental Biology, 2022
Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have ...
Sara E. DiNapoli, Sara E. DiNapoli, Raúl Martinez-McFaline, Raúl Martinez-McFaline, Hao Shen, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Isabel Nelson, Courtney A. Balgobin, Courtney A. Balgobin, Caitlin T. Bourque, Caitlin T. Bourque, Jun Yao, Jun Yao, Renuka Raman, Renuka Raman, Wendy Béguelin, Wendy Béguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Ari M. Melnick, Yariv Houvras, Yariv Houvras, Yariv Houvras   +28 more
doaj   +1 more source