Results 11 to 20 of about 175,165 (326)

Methyltransferases of Riboviria

Biomolecules, 2022
Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
doaj   +3 more sources

The role of histone methyltransferases in therapeutic resistance of NSCLC [PDF]

Epigenetics
Conventional treatments, including chemotherapy, immunotherapy, targeted therapy and radiotherapy, are effective clinical strategies for non-small cell lung cancer (NSCLC) patients, which can significantly improve life quality and prolong survival time ...
Fuze Zhu, Xudong Yang, Yanlong Yang, Xinghe Tong, Jie Jia, Xingkun Gu, Yunping Zhao, Xiaobo Chen   +7 more
doaj   +2 more sources

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]

, 2013
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman, Du, Jiamu, Feng, Suhua, Jacobsen, Steven E, Johnson, Lianna, Patel, Dinshaw J, Stroud, Hume, Zhong, Xuehua   +7 more
core   +6 more sources

Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

Biomolecules, 2020
The C5-methylation of uracil to form 5-methyluracil (m5U) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions.
Pascal Sirand-Pugnet, Damien Brégeon, Laure Béven, Catherine Goyenvalle, Alain Blanchard, Simon Rose, Henri Grosjean, Stephen Douthwaite, Djemel Hamdane, Valérie de Crécy-Lagard   +9 more
doaj   +1 more source

Different Putative Methyltransferases Have Different Effects on the Expression Patterns of Cellulolytic Genes

Journal of Fungi, 2023
Putative methyltranferase LaeA and LaeA-like proteins, conserved in many filamentous fungi, regulate fungal growth, development, virulence, the biosynthesis of secondary metabolites, and the production of cellulolytic enzymes.
Zhongjiao Liu, Kexuan Ma, Xiujun Zhang, Xin Song, Yuqi Qin   +4 more
doaj   +1 more source

Methylation of Ribosomal RNA: A Mitochondrial Perspective

Frontiers in Genetics, 2020
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitochondrial ribosomes (mitoribosomes) are responsible for the synthesis of 13
M. Isabel G. Lopez Sanchez, M. Isabel G. Lopez Sanchez, Miriam Cipullo, Miriam Cipullo, Shreekara Gopalakrishna, Shreekara Gopalakrishna, Anas Khawaja, Anas Khawaja, Joanna Rorbach, Joanna Rorbach   +9 more
doaj   +1 more source

Association of N6-methyladenosine with viruses and virally induced diseases

Frontiers in Bioscience-Landmark, 2020
N6-methyladenosine (m6A) modification, which alters gene expression, is the most prevalent internal modification of eukaryotic mRNA. m6A modification is dynamic and reversible that is regulated by three associated protein groups: methyltransferases or ...
Fang Wu, Wenzhao Cheng, Feiyuan Zhao, Mingqing Tang, Yong Diao, Ruian Xu   +5 more
doaj   +1 more source

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

Cell, 1999
The establishment of DNA methylation patterns requires de novo methylation that occurs predominantly during early development and gametogenesis in mice.
M. Okano, D. Bell, D. Haber, E. Li
semanticscholar   +1 more source

Expression of DNMTs and H3K9ac in Ameloblastoma and Ameloblastic Carcinoma

Frontiers in Oral Health, 2021
Objectives: DNA methyltransferases (DNMTs) and the histone modification H3K9ac are epigenetic markers. This study aimed to describe the immunohistochemical expression of DNMT1, DNMT3A, DNMT3B, and H3K9ac in the dental follicle (DF), ameloblastoma (AME ...
Gleyson Kleber do Amaral-Silva, Thayná Melo de Lima Morais, Vivian Petersen Wagner, Manoela Domingues Martins, Eduardo Rodrigues Fregnani, Fernando Augusto Soares, André Caroli Rocha, Helder Rabelo Pontes, Alan Roger Santos-Silva, Pablo Agustin Vargas   +9 more
doaj   +1 more source

DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy

Cancers, 2020
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals, DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal biological functions, such as embryo development, cell differentiation and gene ...
Jiayu Zhang, Cheng Yang, Chunfu Wu, Wei Cui, Lihui Wang   +4 more
semanticscholar   +1 more source