Results 31 to 40 of about 64,774 (259)
Biology, 2015 A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper
Sarah J. Morse +4 more
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Journal of Cardiovascular Development and Disease, 2023 Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu +5 more
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The DNA methyltransferases of mammals [PDF]
Human Molecular Genetics, 2000 The biological significance of 5-methylcytosine was in doubt for many years, but is no longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by biochemical tests to be involved in the establishment, maintenance or interpretation of genomic methylation patterns is encoded by an essential gene. A human genetic disorder (
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Epigenetics, 2017 Accumulating evidence has recently shown that protein methyltransferases and demethylases are crucial regulators in either maintaining pluripotent states or inducing differentiation of embryonic stem cells. These enzymes control pluripotent signatures by
Theodore Vougiouklakis +2 more
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Journal of Infection in Developing Countries, 2015 This item has no abstract. Follow the links belo to access the full text.
Joel Filgona +2 more
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Targeting Viral Methyltransferases: An Approach to Antiviral Treatment for ssRNA Viruses
Viruses, 2022 Methyltransferase enzymes have been associated with different processes within cells and viruses. Specifically, within viruses, methyltransferases are used to form the 5′cap-0 structure for optimal evasion of the host innate immune system. In this paper,
Peter Ramdhan, Chenglong Li
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Frontiers in Cell and Developmental Biology, 2023 Neurodevelopmental disorders encompass a group of debilitating diseases presenting with motor and cognitive dysfunction, with variable age of onset and disease severity.
Charlotte Roth +5 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
rRNA methyltransferases and their role in resistance to antibiotics [PDF]
Journal of Medical Biochemistry, 2010 Methyltransferases (MTases), a large protein superfamily, commonly use S-adenosyl-L-methionine (SAM) as the methyl group donor. SAM-dependant MTases methylate both nucleic acids (DNA, RNA) and proteins, and thus modulate their activity, function and ...
Morić Ivana +5 more
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