Results 31 to 40 of about 175,165 (326)

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. [PDF]

, 2009
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1).
Bernatavichute, Yana V, Cokus, Shawn, Feng, Suhua, Jacob, Yannick, Jacobsen, Steven E, Johnson, Lianna M, LeBlanc, Chantal A, Michaels, Scott D, Pellegrini, Matteo, Stroud, Hume   +9 more
core   +1 more source

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]

, 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Capri, Miriam, Ciccarone, Fabio, Dollé, Martijn, Franceschi, Claudio, Gonos, Efstathios S, Grubeck Loebenstein, Beatrix, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Hurme, Mikko, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno Villanueva, María, Reale, Anna, Schӧn, Christiane, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Zampieri, Michele   +26 more
core   +2 more sources

Detection of substrate binding motifs for morphine biosynthetic pathway intermediates in novel wound inducible (R,S)-reticuline 7-O-methyltransferase of Papaver somniferum [PDF]

, 2011
The benzylisoquinoline alkaloids (BIA) comprise a large and diverse group of nitrogen-containing secondary metabolites with about 2500 compounds identified in plants.
Abha Meena, Dharmendra Kumar Yadav, Feroz Khan, Rakesh K. Shukla, Sema Singh, Sonal Mishra   +5 more
core   +2 more sources

The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

Frontiers in Cellular and Infection Microbiology, 2019
Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis.
Changming Chen, Xiuyan Han, Qiulong Yan, Chao Wang, Liqiu Jia, Ayaz Taj, Lizhe Zhao, Yufang Ma, Yufang Ma   +8 more
doaj   +1 more source

Role of Mammalian DNA Methyltransferases in Development.

Annual Review of Biochemistry, 2019
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT families, DNMT3 and DNMT1, are responsible for methylation establishment and ...
Zhiyuan Chen, Yi Zhang
semanticscholar   +1 more source

Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

BMC Medicine, 2011
Soft tissue sarcomas of childhood are a group of heterogeneous tumors thought to be derived from mesenchymal stem cells. Surgical resection is effective only in about 50% of cases and resistance to conventional chemotherapy is often responsible for ...
Giordano Antonio, Miele Lucio, Ciarapica Roberta, Locatelli Franco, Rota Rossella   +4 more
doaj   +1 more source

Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]

, 2015
Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane, Mozzetta, Chiara, Pontis, Julien   +2 more
core   +2 more sources

Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases

Molecules, 2022
In plants, methylation is a common step in specialized metabolic pathways, leading to a vast diversity of natural products. The methylation of these small molecules is catalyzed by S-adenosyl-l-methionine (SAM)-dependent methyltransferases, which are ...
Audrey Lashley, Ryan Miller, Stephanie Provenzano, Sara-Alexis Jarecki, Paul Erba, Vonny Salim   +5 more
doaj   +1 more source

Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. [PDF]

, 2010
The crystal structure of Dhaf4260 from Desulfitobacterium hafniense DCB-2 was determined by single-wavelength anomalous diffraction (SAD) to a resolution of 2.01 Å using the semi-automated high-throughput pipeline of the Joint Center for Structural ...
Abdubek, Polat, Aravind, L, Astakhova, Tamara, Axelrod, Herbert L, Bakolitsa, Constantina, Carlton, Dennis, Chiu, Hsiu Ju, Clayton, Thomas, Deacon, Ashley M, Deller, Marc C, Duan, Lian, Elsliger, Marc André, Feuerhelm, Julie, Godzik, Adam, Grant, Joanna C, Han, Gye Won, Hodgson, Keith O, Jaroszewski, Lukasz, Jin, Kevin K, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Krishna, S Sri, Kumar, Abhinav, Lesley, Scott A, Marciano, David, McMullan, Daniel, Miller, Mitchell D, Morse, Andrew T, Nigoghossian, Edward, Okach, Linda, Reyes, Ron, Rife, Christopher L, van den Bedem, Henry, Weekes, Dana, Wilson, Ian A, Wooley, John, Xu, Qingping   +37 more
core   +3 more sources

Melatonin-Mediated Development of Ovine Cumulus Cells, Perhaps by Regulation of DNA Methylation

Molecules, 2018
Cumulus cells of pre-pubertal domestic animals are dysfunctional, perhaps due to age-specific epigenetic events. This study was designed to determine effects of melatonin treatment of donors on methylation modification of pre-pubertal cumulus cells ...
Yi Fang, Shoulong Deng, Jinlong Zhang, Haijun Liu, Yihai Li, Xiaosheng Zhang, Yixun Liu   +6 more
doaj   +1 more source