Results 1 to 10 of about 53,955 (247)

Removal of H3K27me3 by JMJ Proteins Controls Plant Development and Environmental Responses in Arabidopsis

Frontiers in Plant Science, 2021
Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals.
Nobutoshi Yamaguchi
doaj   +1 more source

Functions and Interactions of Mammalian KDM5 Demethylases

Frontiers in Genetics, 2022
Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes.
E. Pavlenko, Till Ruengeler, P. Engel, S. Poepsel   +3 more
semanticscholar   +1 more source

Evolutionary History of RNA Modifications at N6-Adenosine Originating from the R-M System in Eukaryotes and Prokaryotes

Biology, 2022
Methylation at the N6-position of adenosine (N6mA) on mRNA (m6A) is one of the most widespread, highly selective and dynamically regulated RNA modifications and plays an important role in transcription and translation.
Congshan Liu, Jianping Cao, Haobing Zhang, Jianhai Yin   +3 more
doaj   +1 more source

Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2021
The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang, Ying Luan, Rui-Xia Yuan, Yi Luan   +3 more
doaj   +1 more source

Targeting histone demethylases as a potential cancer therapy (Review).

International Journal of Oncology, 2022
Post‑translational modifications of histones by histone demethylases have an important role in the regulation of gene transcription and are implicated in cancers.
Wenfei Diao, Jiabin Zheng, Yong Li, Junjiang Wang, Songhui Xu   +4 more
semanticscholar   +1 more source

KDM6 Demethylases and Their Roles in Human Cancers

Frontiers in Oncology, 2021
Cancer therapy is moving beyond traditional chemotherapy to include epigenetic approaches. KDM6 demethylases are dynamic regulation of gene expression by histone demethylation in response to diverse stimuli, and thus their dysregulation has been observed
Chunyan Hua, Jiaqing Chen, Shuting Li, Jianan Zhou, Jiahong Fu, Weijian Sun, Wenqian Wang   +6 more
semanticscholar   +1 more source

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
core   +1 more source

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

N6-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury

Therapeutic Advances in Chronic Disease, 2020
Background: Although N6-methyladenosine (m6A) plays a very important role in different biological processes, its function in the brain has not been fully explored.
Kaiwei Xu, Yunchang Mo, Dan Li, Qimin Yu, Lu Wang, Feihong Lin, Chang Kong, Meita Felicia Balelang, Anqi Zhang, Sijia Chen, Qinxue Dai, Junlu Wang   +11 more
semanticscholar   +1 more source

Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.

Journal of Medicinal Chemistry, 2021
The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair ...
Gemma S Perry, Mohua Das, E. Woon
semanticscholar   +1 more source