Results 1 to 10 of about 25,929 (279)
Cells, 2022 Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this ...
Joyce Taylor-Papadimitriou +2 more
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H3K27 Demethylases, at Long Last [PDF]
Cell, 2007 Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al.
Wysocka, Joanna, Swigut, Tomek
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Genome-Wide Analysis of DNA Demethylases in Land Plants and Their Expression Pattern in Rice
PlantsDNA demethylation is a very important biochemical pathway regulating a group of biological processes, such as embryo development, fruit ripening, and response to stress.
Shengxin Mao +4 more
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Epigenetics, 2017 Accumulating evidence has recently shown that protein methyltransferases and demethylases are crucial regulators in either maintaining pluripotent states or inducing differentiation of embryonic stem cells. These enzymes control pluripotent signatures by
Theodore Vougiouklakis +2 more
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Technology in Cancer Research and Treatment, 2020 Background & Aims: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular ...
Guojiang Chen, Ziling Liu
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Roles of KDM5 demethylases in therapeutic resistance of cancers [PDF]
Epigenetics & ChromatinEpigenetic modifications, including the regulation of histone H3 lysine 4 methylation (H3K4me2/3), play critical roles in maintaining normal tissue homeostasis and influencing the progression of cancer, including growth, invasion, metastasis, and ...
Xiaobo Chen +7 more
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Histone demethylases in development and disease
Trends in Cell Biology, 2010 Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types ...
Kristian Helin +3 more
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Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
Epigenetics, 2017 Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation.
Hideaki Niwa, Takashi Umehara
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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
Pharmaceuticals, 2012 The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Fernando Lizcano, Lizcano Fernando
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A new role for histone demethylases in the maintenance of plant genome integrity [PDF]
eLife, 2020 Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes.
Javier Antunez-Sanchez +17 more
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