Results 41 to 50 of about 25,929 (279)

Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc

Molecules
Curcumin-mediated anti-cancer properties have been correlated with the inhibition of oncogenic molecules such as mutp53 and c-Myc. Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic functions, and c ...
Roberta Santarelli, Claudia Di Dio, Michele Di Crosta, Paola Currà, Roberta Gonnella, Mara Cirone   +5 more
doaj   +1 more source

Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis

, 2023
ObjectivesIn osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases.
Qiongfei Zhou, Zhou, Qiongfei, Meulenbelt, I., Storms, L., Monteagudo, S., Pazmino, S., Assi, R., Lories, Rik J.J., Almeida, R.C. de, Lories, R.J., Monteagudo, Silvia, Lies Storms, Reem Assi, Storms, Lies, Ingrid Meulenbelt, Cornelis, Frederique M.F., Rodrigo Coutinho de Almeida, Frederique M.F. Cornelis, Silvia Monteagudo, de Almeida, Rodrigo Coutinho, Assi, Reem, Cherifi, Chahrazad, Chahrazad Cherifi, Pazmino, Sofia, Meulenbelt, Ingrid, Zhou, Q.F., Cherifi, C., Cornelis, F.M.F., Rik J. Lories, Sofia Pazmino   +29 more
core   +1 more source

Histone Lysine Demethylase Inhibitors [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar, Jamie N, Anastas, Yang, Shi   +2 more
openaire   +2 more sources

Histone demethylases in chromatin biology and beyond

, 2015
Histone methylation plays fundamental roles in regulating chromatin‐based processes. With the discovery of histone demethylases over a decade ago, it is now clear that histone methylation is dynamically regulated to shape the epigenome and regulate ...
Klose, Robert J., Robert J Klose, Turberfield, Anne H., Anne H Turberfield, Dimitrova, Emilia, Emilia Dimitrova   +5 more
core   +1 more source

Identification and experimental validation of a circular RNA associated with demethylase genes in maize

Аграрная наука Евро-Северо-Востока
In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow plants to adapt to stress without
A. N. Knyazev, O. V. Razumova, L. N. Efremova, Y. N. Smotrova, P. N. Kharchenko   +4 more
doaj   +1 more source

Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana

Frontiers in Plant Science, 2022
Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka, Eng-Seng Gan, Nana Otsuka, Makoto Shirakawa, Toshiro Ito   +4 more
doaj   +1 more source

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean

Plants, 2022
Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu, Jiacan Jiang, Yapeng Han, Mengying Shi, Xianli Li, Yingxiang Wang, Zhicheng Dong, Cunyi Yang   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Inhibitors of Protein Methyltransferases and Demethylases

Chemical Reviews, 2017
Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression and transcription and are implicated in cancer and many other diseases. Many of these enzymes also target various nonhistone proteins impacting numerous crucial biological pathways.
H. Ümit Kaniskan, Michael L. Martini, Jian Jin   +2 more
openaire   +2 more sources

The catalytic domain of JMJD2 and JARID- JmjC family demethylases.

, 2016
A. Sequence alignment of JmjC domains of JMJD2 and JARID demethylases from human (Hs), A. nidulans (An) and S. cerevisiae (Sc). Conserved residues responsible for the catalytic activity are marked in yellow (α-ketoglutarate binding site) and blue (Fe2 ...
Takahiko Sasaki (2257069), Clemens Gruber (544217), Agnieszka Gacek-Matthews (3070551), Joseph Strauss (491039), Harald Berger (752698), Kathrin Wittstein (2015773), Zachary A. Lewis (213044)   +6 more
core   +1 more source