Results 61 to 70 of about 53,955 (247)
Cell & BioscienceN6-methyladenosine (m6A) is dynamically regulated by methyltransferases (termed “writers”) and demethylases (referred to as “erasers”), facilitating a reversible modulation.
Zewei Gao +4 more
semanticscholar +1 more source
In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieRNA methylation modifications are widespread in eukaryotes and prokaryotes, with N6-methyladenosine (m6A) the most common among them. Demethylases, including Fat mass and obesity associated gene (FTO) and AlkB homolog 5 (ALKBH5), are important in ...
Junchen Guo +10 more
semanticscholar +1 more source
The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
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Inhibitors of Protein Methyltransferases and Demethylases
Chemical Reviews, 2017 Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression and transcription and are implicated in cancer and many other diseases.
H. Kaniskan +2 more
semanticscholar +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020 In recent years, there have been remarkable scientific advancements in the understanding of lysine demethylases (KDMs) because of their demethylation of diverse substrates, including nucleic acids and proteins.
Sarder Arifuzzaman +2 more
semanticscholar +1 more source
Cancer Research, 2020 Pharmacologic inhibition of H3K27-demethylases in human chordoma cells promotes epigenetic silencing of oncogenic TBXT, alters gene networks critical to survival, and represents a potential novel therapy. Expression of the transcription factor brachyury (
Lucia Cottone +15 more
semanticscholar +1 more source
Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. [PDF]
, 2020 Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
Choi, Yoon +4 more
core
Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence [PDF]
, 2008 Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Xiaofan Zhou, Hong Ma
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Technology in Cancer Research & Treatment, 2020 Background & Aims: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular ...
Yang Zheng PhD +3 more
doaj +1 more source