Results 61 to 70 of about 25,929 (279)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

, 2011
To investigate ligand selectivity between the oncogenic KDM4C and tumor repressor protein KDM6A histone demethylases, KDM4C and KDM6A were enzymatically characterized, and subsequently, four compounds were tested for inhibitory effects.
Kristensen, Jesper Langgaard, Nielsen, Anders L., Olsen, Lars, Rasmus P. Clausen, Kristensen, Line Hyltoft, Michael Gajhede, Kristensen, Jesper L., Nielsen, Anders L, Anders L. Nielsen, Kastrup, Jette Sandholm, Clausen, Rasmus Prætorius, Clausen, Rasmus P., Lars Olsen, Kristensen, Line H., Charlotte Helgstrand, Gajhede, Michael, Kristensen, Jan B.L., Juknaite, Lina, Jesper L. Kristensen, Jette S. Kastrup, Helgstrand, Charlotte, Kastrup, Jette S., Jan B.L. Kristensen, Line H. Kristensen, Jørgensen, Lars, Lina Juknaite, Kristensen, Jan B L, Lars Jørgensen   +27 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function [PDF]

Cell Research, 2010
LSD1 (KDM1 under the new nomenclature) was the first identified lysine-specific histone demethylase belonging to the flavin-dependent amine oxidase family. Here, we report that AOF1 (KDM1B under the new nomenclature), a mammalian protein related to LSD1, also possesses histone demethylase activity with specificity for H3K4me1 and H3K4me2.
Ze, Yang, Jun, Jiang, M David, Stewart, David M, Stewart, Shankang, Qi, Kenichi, Yamane, Jiwen, Li, Yi, Zhang, Jiemin, Wong   +8 more
openaire   +2 more sources

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

JMJD family proteins in cancer and inflammation

Signal Transduction and Targeted Therapy, 2022
The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni, Xue Jianxin, Hong Weiqi, Chen Siyuan, Shi Huashan   +4 more
doaj   +1 more source

Role of H3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation

, 2010
The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression ...
M. R. Hubner, Spector, D. L., D. L. Spector, Hubner, M. R.   +3 more
core   +1 more source

Histone demethylase Expression Across Lifestages: Transcript expression provided for predicted histone demethylases are plotted against B. malayi lifestages.

, 2022
All values were taken from Wormbase. Tabs are separated as all predicted demethylases, and by jmjC-domain containing or lysin-specific demethylases. (XLSX)
Brittany Hart (12250819), Sreedhar Tummalapalli (12250822), John Siekierka (12250828), Tamara Kreiss (4852729), Tyler Eck (5249684), David Rotella (12250825)   +5 more
core   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis)

Frontiers in Plant Science, 2020
DNA methylation plays an important role in a wide range of developmental and physiological processes in plants. It is primarily catalyzed and regulated by cytosine-5 DNA methyltransferases (C5-MTases) and a group of DNA glycosylases that act as ...
Yaoxin Zhang, Xiaoqing He, Haochen Zhao, Wencai Xu, Heng Deng, Huan Wang, Shuyue Wang, Dan Su, Zhenlei Zheng, Bin Yang, Don Grierson, Jun Wu, Mingchun Liu   +12 more
doaj   +1 more source