Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability.
A. Cribbs +16 more
semanticscholar +1 more source
JMJD family proteins in cancer and inflammation
Signal Transduction and Targeted Therapy, 2022 The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni +4 more
doaj +1 more source
Epigenetic regulation of Epichloë festucae secondary metabolite biosynthesis and symbiotic interaction with Lolium perenne : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Genetics at Massey University, Palmerston North, New Zealand [PDF]
, 2017 Histone methylation is one of several epigenetic layers for transcriptional regulation. Most studies on the importance of this histone modification in regulating fungal secondary metabolite gene expression and pathogenicity have focussed on the role of
Lukito, Yonathan
core
A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David +26 more
core +1 more source
Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants
iScience, 2020 Summary The universal importance of epigenetic regulation has become explicit over the last decade. There is now a detailed understanding of the molecular signatures and chromatin-modifying enzymes determining epigenetic regulation.
Pedro Crevillén
semanticscholar +1 more source
Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
Epigenetics, 2017 Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation.
Hideaki Niwa, Takashi Umehara
doaj +1 more source
Histone demethylases regulate adipocyte thermogenesis [PDF]
Diabetology International, 2018 Adipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness.
openaire +2 more sources
KDM2 is a H3K4me3 demethylase regulating nucleolar organization [PDF]
, 2009 Background CG11033 (dKDM2) is the Drosophila homolog of the gene KDM2B. dKDM2 has been known to possess histone lysine demethylase activity towards H3K36me2 in cell lines and it regulates H2A ubiquitination.
Harsh H Kavi, James A Birchler
core +2 more sources
Genome-Wide Identification of DNA Methylases and Demethylases in Kiwifruit (Actinidia chinensis)
Frontiers in Plant Science, 2020 DNA methylation plays an important role in a wide range of developmental and physiological processes in plants. It is primarily catalyzed and regulated by cytosine-5 DNA methyltransferases (C5-MTases) and a group of DNA glycosylases that act as ...
Yaoxin Zhang +12 more
doaj +1 more source
Cells, 2022 Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC).
Dawid Dorna, Jarosław Paluszczak
doaj +1 more source