Results 101 to 110 of about 25,929 (279)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Mechanistic studies on histone demethylases and related enzymes

, 2013
Histone lysyl demethylases (2OG demethylases) are a family of nuclear proteins that catalyse the demethyation of Nε-methylated lysines on histone tails.
Hopkinson, Richard James
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities

Current Issues in Molecular Biology
Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu, Min Huang, Xia Tian, Xiaodong Huang   +3 more
doaj   +1 more source

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, EarlyView.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

, 2006
SummaryHistone methylation regulates chromatin structure, transcription, and epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, which mediate demethylation of di- and ...
Shi, Yang, Huarte, Maite, Li, En, Whetstine, Johnathan R., Spooner, Eric, Lan, Fei, Nottke, Amanda, Chen, Zhongzhou, Zhang, Gongyi, Smolikov, Sarit, Colaiacovo, Monica   +10 more
core   +1 more source

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]

, 2010
Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Erck, C, Böttger, Angelika, Burrells Alison, Andreas Lengeling, Butler, Danica, Hahn, P., Erck, Christian, Wolf, A., Lengeling, A., Bottger, A., Jens Böse, Erck, C., Christopher J Schofield, Hahn, P, Wegener, Ivonne, Wegener Ivonne, Böse, Jens, Christian Erck, Angelika Böttger, Burrells, A, Ivonne Wegener, Butler, D, Butler Danica, Lengeling Andreas, Böse Jens, Burrells, A., Alexander Wolf, Hahn Phillip, Wolf, A, Bose, J., Lengeling, A, Erck Christian, Böttger Angelika, Danica Butler, Phillip Hahn, Butler, D., Wolf Alexander, Hahn, Phillip, Wolf, Alexander, Schofield, Christopher J, Alison Burrells, Schofield Christopher J., Böse, J, Lengeling, Andreas, Schofield, Christopher J., Wegener, I, Schofield, CJ, Wegener, I., Burrells, Alison, Schofield, Christopher, Böttger, A, Christopher J. Schofield   +51 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Exploring the substrate scope of histone demethylases

, 2021
Post-translational modifications of histones play key roles in regulation of eukaryotic transcription and in epigenetics. Lysine methylation of histones is a dynamic balance between activity of methyl transferases and demethylases (KDMs).
Bonnici, Joanna
core   +1 more source