Results 101 to 110 of about 53,955 (247)

Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations [PDF]

, 2014
__Background:__ Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of ...
Drabkin, H.A. (Harry), Fiser, K. (Karel), Fornerod, M.W.J. (Maarten), Heuvel-Eibrink, M.M. (Marry) van den, Kramarzova, K.S. (Karolina Skvarova), Mejstříková, E. (Ester), Rejlova, K. (Katerina), Starkova, J. (Julia), Stary, J. (Jan), Trka, J. (Jan), Zaliova, M. (Marketa)   +10 more
core   +1 more source

Histone Demethylases in Cancer [PDF]

Current Pharmacology Reports, 2015
Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases.
Satheesh Sainathan, Santanu Paul, Satish Ramalingam, Joaquina Baranda, Shrikant Anant, Animesh Dhar   +5 more
openaire   +1 more source

Structural requirements for substrate recognition of Mycobacterium tuberculosis 14α-demethylase: implications for sterol biosynthesis

Journal of Lipid Research, 2001
Sterol 14α-demethylase (14DM) is a cytochrome P-450 involved in sterol biosynthesis in eukaryotes. It was reported that Mycobacterium smegmatis also makes cholesterol and that cholesterol is essential to Mycobacterium tuberculosis (MT) infection ...
Aouatef Bellamine, Anil T. Mangla, Allen L. Dennis, W. David Nes, Michael R. Waterman   +4 more
doaj   +1 more source

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia [PDF]

, 2013
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options.
A Subramanian, A Tsirigos, AA Mansour, Adolfo A. Ferrando, Alexandros Strikoudis, AM Jankowska, AP Weng, Aristotelis Tsirigos, B King, B Langmead, BG Mar, Bryan King, C Morales Torres, C Simon, C Wang, CG Mullighan, CG Mullighan, Charles G. Mullighan, DI Marks, Elisabeth Paietta, Evangelia Loizou, F Armstrong, F De Santa, G van Haaften, G. Grant Welstead, GG Welstead, Giovanni Tonon, GL Sen, H Wang, Iannis Aifantis, J Zhang, J Zhang, Jacob M. Rowe, Jared Becksfort, Jasper Mullenders, Jelena Nedjic, JK Wang, K Agger, K Chen, K Jepsen, L Espinosa, L Kruidenier, L Wang, Laurens Kruidenier, Linda Holmfeldt, Luyao Xu, M Barradas, Martin S. Tallman, MR Hubner, P Ntziachristos, P Van Vlierberghe, Panagiotis Ntziachristos, Pieter Van Vlierberghe, PJ Valk, Q Li, RA Dickins, Rab Prinjha, RG Verhaak, Rudolf Jaenisch, S Thieme, S Zhong, SB Baylin, Shizuo Akira, SM Kooistra, Sofia Bakogianni, T Palomero, T Satoh, Takashi Satoh, Thomas Trimarchi, VM Sharma, W Zhao, WA Dik, Y Zhang   +72 more
core   +2 more sources

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

BMC Cancer, 2012
Background The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We
Shen Yongqing, Guo Xiaoqiang, Wang Yuejia, Qiu Wei, Chang Yanzhong, Zhang Aili, Duan Xianglin   +6 more
doaj   +1 more source

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Nature Communications, 2017
The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available.
A. Kawamura, M. Münzel, T. Kojima, C. Yapp, Bhaskar Bhushan, Yuki Goto, A. Tumber, T. Katoh, Oliver N. F. King, T. Passioura, L. Walport, S. Hatch, S. Madden, S. Müller, P. Brennan, R. Chowdhury, Richard J. Hopkinson, H. Suga, C. Schofield   +18 more
semanticscholar   +1 more source

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

PLoS ONE, 2010
BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov   +16 more
doaj   +1 more source

Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase [PDF]

, 2000
An Acinetobacter sp. genetic screen was used to probe structure-function relationships in vanillate demethylase, a two-component monooxygenase. Mutants with null, leaky, and heat-sensitive phenotypes were isolated.
Morawski, Birgit, Ornston, L. Nicholas, Segura, Ana   +2 more
core  

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]

, 2017
BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W, Hodgson, Jacob W, Li, Taosui, Mazo, Alexander, Petruk, Svetlana   +4 more
core   +2 more sources

Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.

Molecular Genetics and Metabolism, 2019
Histone demethylases remove transcriptional repressive marks from histones in the nucleus. KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine at position 27 in histone 3. The KDM6A gene is located on the X chromosome
I. Gazova, A. Lengeling, K. Summers
semanticscholar   +1 more source