Results 111 to 120 of about 53,955 (247)

Functions of RNA N⁶-Methyladenosine Demethylases in Plant Development and Stress Responses

Agronomy
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, regulates gene expression by modulating mRNA metabolism. Demethylases (“erasers”) specifically remove these m6A marks. In mammals, FTO and ALKBH5 (ALKBH family members)
Ran Su, Ying Cao, Wenjie Yu, Shanhua Lyu, Yinglun Fan, Haiyun Li   +5 more
doaj   +1 more source

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]

, 2014
TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA, Caiafa, Paola, Calabrese, Roberta, Ciccarone, Fabio, Franceschi, C, Guastafierro, Tiziana, Mariano, Germano, Reale, Anna, Valentini, Elisabetta, Zampieri, Michele   +9 more
core   +6 more sources

HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: EFFECT OF CYANIDE ON MICROSOMAL N-DEMETHYLASE ACTIVITY

Japanese Journal of Pharmacology, 1977
Cyanide, an inhibitor of many hemoproteins, was shown to affect a number of microsomal drug-metabolizing activities catalyzed by cytochrome P-450. The N-demethylation reaction of aminopyrine was inhibited noncompetitively by this inhibitor in microsomal preparations from rats.
T, Matsubara, A, Touchi
openaire   +3 more sources

Oncometabolites: tailoring our genes [PDF]

, 2015
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core   +1 more source

Epigenetic therapy in urologic cancers: an update on clinical trials [PDF]

, 2016
Epigenetic dysregulation is one of many factors that contribute to cancer development and progression. Numerous epigenetic alterations have been identified in urologic cancers including histone modifications, DNA methylation changes, and microRNA ...
Agarwal, Aggarwal, Alon, Anant, Arbor, Bassi, Bastian, Bates, Baylin, Benevolenskaya, Bologna, Borden, Burris, Cairns, Cairns, Carducci, Carducci, Catto, Chi, Clark, Clark, Cole, Croce, Croce, Dahiya, Dahiya, de Balincourt, de Bono, de Bono, Domingos, Dorr, Ehtejab, Eisen, Eisenberger, Eisenberger, Eisenhauer, Eisenhauer, Ekström, Ellinger, Ferrari, Festuccia, Fuessel, Fuessel, Gleave, Grant, Gregory, Griffiths, Han, Harland, Heinrich, Helin, Helin, Hennenlotter, Hsiao, Huang, Hussain, Investigators, Investigators, Issa, Jemal, Jeronimo, Jones, Kiltie, Kim, Kim, Kouzarides, Kouzarides, Kristiansen, Kristiansen, Liang, Liang, Lin, Lyko, Maitland, Manoharan, Marks, Martel, Martell, Meeran, Muller, Nelson, Ochiya, Ogawa, Osman, Pectasides, Pili, Pili, Pompidou, Ren, Rudek, Sartor, Sawyers, Schellhammer, Scher, Sediqe, Shariat, Shi, Sidransky, Sukumar, Tewari, Tolcher, Tolcher, Torti, Verma, Verma, Visakorpi, Von Hoff, Von Ruecker, Wilding, Winquist, Wu, Ørntoft   +111 more
core   +1 more source

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells

Journal of Biological Chemistry, 2018
Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the ...
A. Cribbs, E. Hookway, G. Wells, M. Lindow, S. Obad, H. Oerum, R. Prinjha, N. Athanasou, A. Sowman, M. Philpott, H. Penn, K. Soderstrom, M. Feldmann, U. Oppermann   +13 more
semanticscholar   +1 more source

Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]

, 2015
Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane, Mozzetta, Chiara, Pontis, Julien   +2 more
core   +2 more sources

Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities

Current Issues in Molecular Biology
Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu, Min Huang, Xia Tian, Xiaodong Huang   +3 more
doaj   +1 more source

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1

Cell Reports, 2018
SUMMARY How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical ...
J. Camacho, Lisa Truong, Zeyneb Kurt, Yen-Wei Chen, M. Morselli, Gerardo M. Gutierrez, M. Pellegrini, Xia Yang, P. Allard   +8 more
semanticscholar   +1 more source