Results 91 to 100 of about 53,955 (247)
Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
core +5 more sources
Stem Cell Reports, 2020 Summary Histone H3 lysine 9 (H3K9) methylation is dynamically regulated by methyltransferases and demethylases. In spermatogenesis, prospermatogonia differentiate into differentiating or undifferentiated spermatogonia after birth. However, the epigenetic
Shunsuke Kuroki +7 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed +9 more
doaj +1 more source
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core +2 more sources
Role of H3K9 demethylases in DNA double-strand break repair.
Journal of Cancer Biology, 2020 H3K9 demethylases can remove the repressive H3K9 methylation marks on histones to alter chromatin structure, gene transcription and epigenetic state of cells.
H. Jeon, A. Hussain, Jianfei Qi
semanticscholar +1 more source
Chemical Biology of Lysine Demethylases [PDF]
Current Chemical Genomics, 2011 Abnormal levels of DNA methylation and/or histone modifications are observed in patients with a wide variety of chronic diseases. Methylation of lysines within histone tails is a key modification that contributes to increased gene expression or repression depending on the specific residue and degree of methylation, which is in turn controlled by the ...
openaire +2 more sources
NF-κB: Regulation by Methylation [PDF]
, 2015 In normal cells exposed to stress, the central transcription factor NF-κB is activated only transiently, to modulate the activation of downstream immune responses.
Lu, Tao, Stark, George R.
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Discovery and structural studies of histone demethylases
Frontiers in Epigenetics and EpigenomicsThe discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng +5 more
doaj +1 more source
Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
Pharmaceuticals, 2012 The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Jeison Garcia, Fernando Lizcano
doaj +1 more source
Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +2 more
core +3 more sources