Results 91 to 100 of about 25,929 (279)
Chemical Biology of Lysine Demethylases [PDF]
Current Chemical Genomics, 2011 Abnormal levels of DNA methylation and/or histone modifications are observed in patients with a wide variety of chronic diseases. Methylation of lysines within histone tails is a key modification that contributes to increased gene expression or repression depending on the specific residue and degree of methylation, which is in turn controlled by the ...
openaire +2 more sources
Expression and significance of histone H3K27 demethylases in renal cell carcinoma
BMC Cancer, 2012 Background The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We
Shen Yongqing +6 more
doaj +1 more source
Purification of histone demethylases from HeLa cells
, 2006 Posttranslational histone modifications play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues and participates in diverse range of biological processes ...
ZHANG, Y, TSUKADA, Y
core +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Role of H3K4 demethylases in complex neurodevelopmental diseases
, 2010 Significant neurological disorders can result from subtle perturbations of gene regulation that are often linked to epigenetic regulation. Proteins that regulate the methylation of lysine 4 of histone H3 (H3K4) and play a central role in epigenetic ...
Christopher Wynder +2 more
core +1 more source
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets [PDF]
, 2021 The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair ...
Perry, GS, Das, M, Woon, ECY
core
Biotechnology and Bioengineering, EarlyView.ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian +4 more
wiley +1 more source
Functions of RNA N6-Methyladenosine Demethylases in Plant Development and Stress Responses
AgronomyN6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, regulates gene expression by modulating mRNA metabolism. Demethylases (“erasers”) specifically remove these m6A marks. In mammals, FTO and ALKBH5 (ALKBH family members)
Ran Su +5 more
doaj +1 more source
Inhibitors of JmjC-containing histone demethylases
, 2020 Histone demethylases (KDMs) catalyse the removal of N-methyl marks on histones and play important roles in epigenetic regulation. Abnormal histone methylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as ...
Kawamura, A +5 more
core +1 more source
Functions and Interactions of Mammalian KDM5 Demethylases
, 2022 Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes.
Pavlenko, Egor +3 more
core +1 more source