Results 71 to 80 of about 53,955 (247)

Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana

Frontiers in Plant Science, 2022
Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka, Eng-Seng Gan, Nana Otsuka, Makoto Shirakawa, Toshiro Ito   +4 more
doaj   +1 more source

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450_(BM3) demethylases [PDF]

, 2009
Polysaccharides comprise an extremely important class of biopolymers that play critical roles in a wide range of biological processes, but the synthesis of these compounds is challenging because of their complex structures.
Arnold, Frances H., Bastian, Sabine, Bennett, Clay S., Chen, Mike M., Fu, Yu, Greenberg, William A., Lewis, Jared C., Mitsuda, Yuuichi, Wong, Chi-Huey   +8 more
core   +1 more source

Identification and experimental validation of a circular RNA associated with demethylase genes in maize

Аграрная наука Евро-Северо-Востока
In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow plants to adapt to stress without
A. N. Knyazev, O. V. Razumova, L. N. Efremova, Y. N. Smotrova, P. N. Kharchenko   +4 more
doaj   +1 more source

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean

Plants, 2022
Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu, Jiacan Jiang, Yapeng Han, Mengying Shi, Xianli Li, Yingxiang Wang, Zhicheng Dong, Cunyi Yang   +7 more
doaj   +1 more source

Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila [PDF]

, 2017
Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome.
Buszczak, Michael, Eliazer, Susan, Rothenfluh, Adrian, Sayed, Raheel, Scoggin, Shane, Shalaby, Nevine A., Zhang, Qiao   +6 more
core   +1 more source

KDM5 histone demethylases repress immune response via suppression of STING

PLoS Biology, 2018
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer.
Lizhen Wu, Jian Cao, Wesley L. Cai, S. Lang, J. Horton, D. Jansen, Zongzhi Z. Liu, Jocelyn F Chen, Meiling Zhang, B. Mott, Katherine Pohida, Ganesha Rai, Stephen C. Kales, M. Henderson, Xin Hu, A. Jadhav, D. Maloney, A. Simeonov, Shu Zhu, A. Iwasaki, M. Hall, Xiaodong Cheng, G. Shadel, Q. Yan   +23 more
semanticscholar   +1 more source

Hitting histone demethylases [PDF]

Science-Business eXchange, 2012
A GSK–Structural Genomics Consortium team has identified the first potent and selective histone demethylase inhibitor and shown that the molecule dampens the macrophage inflammatory response. The pharma now is focusing on internal efforts and external approaches to exploring potential therapeutic applications of the inhibitor.
openaire   +1 more source

Genome-Wide Analysis of DNA Demethylases in Land Plants and Their Expression Pattern in Rice

Plants
DNA demethylation is a very important biochemical pathway regulating a group of biological processes, such as embryo development, fruit ripening, and response to stress.
Shengxin Mao, Jian Xiao, Yating Zhao, Jiaqi Hou, Lijia Li   +4 more
doaj   +1 more source

The emerging roles for histone demethylases in the modulation of signaling pathways

Biomolecular Concepts, 2013
Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives ...
Di Stefano Luisa, Dyson Nicholas J.
doaj   +1 more source

The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

Biomolecules, 2021
Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle, Heike Luise Pahl, Jonas Samuel Jutzi   +2 more
doaj   +1 more source