Results 71 to 80 of about 25,929 (279)

The Emerging Significance of Histone Lysine Demethylases as Prognostic Markers and Therapeutic Targets in Head and Neck Cancers

Cells, 2022
Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC).
Dawid Dorna, Jarosław Paluszczak
doaj   +1 more source

Mechanisms of human histone and nucleic acid demethylases

, 2012
The discovery that protein and nucleic acid demethylation is common opens up the possibility of 'methylation cycles' of functional importance, including in the regulation of gene expression.
Walport, LJ, Schofield, CJ, Hopkinson, RJ, Schofield, Christopher   +3 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Hairless is a histone H3K9 demethylase

The FASEB Journal, 2013
The hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity. To test whether HR possesses HDM activity, we performed a series of in vitro demethylation assays, which demonstrated that HR can demethylate mono‐
Liang, Liu, Hyunmi, Kim, Alex, Casta, Yuki, Kobayashi, Lawrence S, Shapiro, Angela M, Christiano   +5 more
openaire   +3 more sources

The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes

Frontiers in Cell and Developmental Biology, 2022
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed, Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Hani Choudhry, Firoz Ahmed, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan, Mohammad Imran Khan   +9 more
doaj   +1 more source

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis [PDF]

, 2014
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling.
Kasioulis, Ioannis, Jackson, Ian J., Botting, C. H., Botting, Catherine H., Kasioulis, I., Syred, H. M., Seawright, Anne, Fuszard, Matthew Alexander, Shirran, Sally, Van Heyningen, V., Tate, Peri, Finch, Andrew, Tate, P., Jackson, I. J., Adams, I. R., Syred, Heather M., Finch, A., Yeyati, P. L., Shaw, J., Shirran, S., Fuszard, M., Adams, Ian R., Shaw, Joseph, Seawright, A., Yeyati, Patricia L., van Heyningen, Veronica   +25 more
core   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Investigating the role of ZFP36L2 on the stability of mRNAs encoding histone lysine demethylases in cancer [PDF]

, 2022
Epigenetic regulation has recently been at the forefront of cancer therapeutic research. Multiple therapies that target histone modification factors such as histone lysine deacetylases and histone lysine methyltransferases have entered the market with ...
Ghaffarnejad, Sina
core  

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source