Results 1 to 10 of about 4,569 (102)

The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets [PDF]

Molecular Biomedicine
The Jumonji C domain-containing (JMJD) family of histone demethylases constitutes an essential class of epigenetic regulators that dynamically sculpt gene expression programs through the erasure of methyl groups from histone lysine and arginine residues.
Yilin Hong, Hanshi Guo, Qiang Chen, Chundong Yu   +3 more
doaj   +2 more sources

Genome-wide identification and expression analysis of JmjC domain-containing family in Vitis vinifera L. [PDF]

BMC Genomics
Background In eukaryotes, histone methylation is essential for controlling chromatin structure, gene transcription, and related chromatin processes. Jumonji C (JmjC) domain-containing demethylases (JMJs) regulate histone methylation levels.
Mengqi Wang, Jie Wang, Wangsheng Zhu, Xin Sun   +3 more
doaj   +2 more sources

The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

Biomolecules, 2021
Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle, Heike Luise Pahl, Jonas Samuel Jutzi   +2 more
doaj   +1 more source

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer

Frontiers in Immunology, 2022
Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang, Yuan Hu, Binjing Zhang, Xiao Liang, Xin Li   +4 more
doaj   +1 more source

Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana

Frontiers in Plant Science, 2022
Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka, Eng-Seng Gan, Nana Otsuka, Makoto Shirakawa, Toshiro Ito   +4 more
doaj   +1 more source

Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, 2023
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj   +1 more source

JMJD family proteins in cancer and inflammation

Signal Transduction and Targeted Therapy, 2022
The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni, Xue Jianxin, Hong Weiqi, Chen Siyuan, Shi Huashan   +4 more
doaj   +1 more source

JMJ Histone Demethylases Balance H3K27me3 and H3K4me3 Levels at the HSP21 Locus during Heat Acclimation in Arabidopsis

Biomolecules, 2021
Exposure to moderately high temperature enables plants to acquire thermotolerance to high temperatures that might otherwise be lethal. In Arabidopsis thaliana, histone H3 lysine 27 trimethylation (H3K27me3) at the heat shock protein 17.6C (HSP17.6C) and ...
Nobutoshi Yamaguchi, Toshiro Ito
doaj   +1 more source

Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis

Frontiers in Plant Science, 2020
Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression.
Jinfeng Wu, Jinfeng Wu, Jinfeng Wu, Mingli Yan, Mingli Yan, Dawei Zhang, Dawei Zhang, Dinggang Zhou, Dinggang Zhou, Nobutoshi Yamaguchi, Nobutoshi Yamaguchi, Toshiro Ito   +11 more
doaj   +1 more source

Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

iScience, 2020
Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC).
Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu   +9 more
doaj   +1 more source