Results 11 to 20 of about 6,610 (186)

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases [PDF]

Journal of the American Chemical Society, 2011
Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases are the most recent family of histone-modifying enzymes discovered. Here, we report the characterization of a small-molecule inhibitor of Jumonji C domain-containing histone demethylases.
Luo, X, Liu, Y, Kubicek, S, Myllyharju, J, Tumber, A, Ng, S, Che, K, Podoll, J, Heightman, T, Oppermann, U, Schreiber, S, Wang, X   +11 more
openaire   +5 more sources

Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15 [PDF]

Cancer Biology & Therapy, 2022
The Jumonji C domain-containing family of histone lysine demethylases (Jumonji KDMs) have emerged as promising cancer therapy targets. These enzymes remove methyl groups from various histone lysines and, in turn, regulate processes including chromatin compaction, gene transcription, and DNA repair.
Duan, Lei, Perez, Ricardo E., Calhoun, Sarah, Maki, Carl G.   +3 more
openaire   +4 more sources

Involvement of a Jumonji‐C domain‐containing histone demethylase in DRM2‐mediated maintenance of DNA methylation [PDF]

EMBO reports, 2010
Histone demethylases—both lysine‐specific demethylase 1 (LSD1) and Jumonji‐C (JmjC) domain‐containing proteins—are broadly implicated in the regulation of chromatin‐dependent processes. In Arabidopsis thaliana, histone marks directly affect DNA methylation, and mutations in LSD1 homologues show reduced DNA methylation at some loci. We screened transfer
Deleris, Angelique, Greenberg, Maxim, Ausin, Israel, Law, Rona, Moissiard, Guillaume, Schubert, Daniel, Jacobsen, Steven   +6 more
openaire   +6 more sources

Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, 2023
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj   +1 more source

JMJD family proteins in cancer and inflammation

Signal Transduction and Targeted Therapy, 2022
The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni, Xue Jianxin, Hong Weiqi, Chen Siyuan, Shi Huashan   +4 more
doaj   +1 more source

JMJ Histone Demethylases Balance H3K27me3 and H3K4me3 Levels at the HSP21 Locus during Heat Acclimation in Arabidopsis

Biomolecules, 2021
Exposure to moderately high temperature enables plants to acquire thermotolerance to high temperatures that might otherwise be lethal. In Arabidopsis thaliana, histone H3 lysine 27 trimethylation (H3K27me3) at the heat shock protein 17.6C (HSP17.6C) and ...
Nobutoshi Yamaguchi, Toshiro Ito
doaj   +1 more source

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]

, 2020
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J, Gilbert, Robert C G, Karia, Dimple, Mancini, Erika J, Porcher, Catherine   +4 more
core   +1 more source

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis [PDF]

Annals of the Rheumatic Diseases, 2018
Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on ...
Bergmann, Christina, Brandt, Amelie, Merlevede, Benita, Hallenberger, Ludwig, Dees, Clara, Wohlfahrt, Thomas, Pötter, Sebastian, Zhang, Yun, Chen, Chih-Wei, Mallano, Tatiana, Liang, Ruifang, Kagwiria, Rosebeth, Kreuter, Alexander, Pantelaki, Ioanna, Bozec, Aline, Abraham, David, Rieker, Ralf, Ramming, Andreas, Distler, Oliver, Schett, Georg, Distler, Jörg H W   +20 more
openaire   +4 more sources

Selective small molecule targeting of KDM4 as a therapeutic strategy to reduce proliferation of acute myeloid leukaemia. [PDF]

Br J Haematol
Summary Acute myeloid leukaemia (AML) is an aggressive disease with poor survival and high relapse rates. Coupled with the complex mutational burden observed, there is an unmet clinical need for more targeted therapies. Epigenetic therapies have shown promise both as monotherapy and in combination strategies and specifically histone lysine demethylase,
Monaghan L, Bunschoten RP, Bittencourt-Silvestre J, Park T, Gannon S, Pirvan PA, Hoose A, Wheadon H, Liskamp RMJ, Huang X, Jørgensen HG.   +10 more
europepmc   +2 more sources

Histone demethylase Jumonji domain‐containing 1A inhibits proliferation and progression of gastric cancer by upregulating runt‐related transcription factor 3 [PDF]

Cancer Science, 2020
AbstractThe histone demethylase Jumonji domain‐containing 1A (JMJD1A) is overexpressed in multiple cancers and promotes cancer progression. However, the role and mechanism of JMJD1A in gastric cancer (GC) remains poorly understood. Here, we found that JMJD1A could suppress GC cell proliferation and xenograft tumor growth.
Ke Ning, Yangguang Shao, Yuxin He, Fei Wang, Xi Cui, Furong Liu, Danni Li, Feng Li   +7 more
openaire   +2 more sources