Results 11 to 20 of about 4,588 (118)

FgJhd2 Modulates FgMpf2 Expression via H3K4 Demethylation and Influences Sexual Development in Fusarium graminearum. [PDF]

Environ Microbiol
The histone demethylase FgJhd2 regulates sexual reproduction in the fungal pathogen Fusarium graminearum via H3K4me3 demethylation. Mechanistically, FgJhd2 restricts H3K4 methylation to suppress the expression of FgMpf2, an RNA‐binding protein involved in RNA degradation.
Liao X, Yao L, Wang J, Chen Y, Chen S, Qi Z, Chen Y.   +6 more
europepmc   +2 more sources

Identification of Novel Small-Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects. [PDF]

Cancer Med
ABSTRACT KDM5B, a member of the KDM5 family of histone demethylases, plays a critical role in transcriptional repression by demethylating H3K4me2/3. It regulates key biological processes such as development, stem cell maintenance, and oncogenesis, and its aberrant expression is implicated in various cancers. Accordingly, KDM5B is considered a promising
Hara T, Meng S, Konno M, Nishida N, Koseki J, Meguro K, Kawano Y, Morie T, Dan S, Satoh T, Akai S, Tsujikawa K, Eguchi H, Mori M, Miura Y, Nishiyama N, Ishii H.   +16 more
europepmc   +2 more sources

Vitamin C and epigenetics: A short physiological overview

Open Medicine, 2023
In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role
Pavlovic Voja, Ciric Milan, Petkovic Milan, Golubovic Mladjan   +3 more
doaj   +1 more source

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

Scientific Reports, 2022
JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian regulation in plants and humans and is involved in embryonic development and cell proliferation.
Md. Saiful Islam, Marios Markoulides, Rasheduzzaman Chowdhury, Christopher J. Schofield   +3 more
doaj   +1 more source

Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. [PDF]

PLoS Genetics, 2014
Histone demethylases have emerged as important players in developmental processes. Jumonji domain containing-3 (Jmjd3) has been identified as a key histone demethylase that plays a critical role in the regulation of gene expression; however, the in vivo ...
Qingtian Li, Helen Y Wang, Iouri Chepelev, Qingyuan Zhu, Gang Wei, Keji Zhao, Rong-Fu Wang   +6 more
doaj   +1 more source

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Nature Communications, 2019
Jumonji domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod ...
Shuzhi Zheng, Hongmiao Hu, Huimin Ren, Zhenlin Yang, Qi Qiu, Weiwei Qi, Xinye Liu, Xiaomei Chen, Xiekui Cui, Sisi Li, Bing Zhou, Daye Sun, Xiaofeng Cao, Jiamu Du   +13 more
doaj   +1 more source

JMJD5 attenuates oxygen–glucose deprivation and reperfusion‐induced injury in cardiomyocytes through regulation of HIF‐1α‐BNIP3

Kaohsiung Journal of Medical Sciences, 2022
Proteins in Jumonji family function as histone demethylases and participate in cardiac development. Jumonji domain containing 5 (JMJD5) is responsible for the embryonic development through removing methyl moieties from H3K36me2 histone, and has pro ...
Ya‐Nan Zhang, Ya‐Xiang Pang, Da‐Wei Liu, Hai‐Juan Hu, Rui‐Qin Xie, Wei Cui   +5 more
doaj   +1 more source

Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network. [PDF]

PLoS ONE, 2012
Recent data suggest that the etiology of several metabolic diseases is closely associated with transcriptome alteration by aberrant histone methylation.
Hee-Jin Jun, Jinyoung Kim, Minh-Hien Hoang, Sung-Joon Lee   +3 more
doaj   +1 more source

Genome-wide identification of the jumonji C domain- containing histone demethylase gene family in wheat and their expression analysis under drought stress

Frontiers in Plant Science, 2022
Methylation and demethylation of histone play a crucial role in regulating chromatin formation and gene expression. The jumonji C (JmjC) domain-containing proteins are demethylases that are involved in regulating epigenetic modification in plants. In our
Xinhua Wang, Xinhua Wang, Cuili Pan, Jiaohui Long, Shuangyu Bai, Mingming Yao, Jiajing Chen, Gang Sun, Yalei Fan, Zhangjun Wang, Fenglou Liu, Caixia Liu, Qingfeng Li   +12 more
doaj   +1 more source

Genome-wide analysis of soybean JmjC domain-containing proteins suggests evolutionary conservation following whole-genome duplication

Frontiers in Plant Science, 2016
Histone modifications, such as methylation and demethylation, play an important role in regulating chromatin structure and gene expression. The JmjC domain-containing proteins, an important family of histone lysine demethylases (KDMs), play a key role in
Yapeng Han, Xiangyong Li, Lin Cheng, Yanchun Liu, Hui Wang, Danxia Ke, Hongyu Yuan, Liangsheng Zhang, Lei Wang   +8 more
doaj   +1 more source