Results 21 to 30 of about 6,610 (186)
Frontiers in Plant Science, 2020 Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression.
Jinfeng Wu +11 more
doaj +1 more source
PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]
, 2020 Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio +9 more
core +1 more source
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]
, 2013 Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva +9 more
core +7 more sources
Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]
, 2014 Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi +139 more
core +5 more sources
iScience, 2020 Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC).
Wen Zhang +9 more
doaj +1 more source
Vitamin C and epigenetics: A short physiological overview
Open Medicine, 2023 In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role
Pavlovic Voja +3 more
doaj +1 more source
Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila [PDF]
, 2017 Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome.
Buszczak, Michael +6 more
core +1 more source
Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases
Molecular Medicine Reports, 2018 The E26 transformation-specific (ETS) variant 2 (ETV2) protein, also designated as ETS-related 71, is a member of the ETS transcription factor family and is essential for blood and vascular development in the embryo. The role of ETV2 in cancer has not yet been investigated.
Li, Xiaomeng +4 more
openaire +3 more sources
Critical role of histone demethylase Jumonji domain-containing protein 3 in the regulation of neointima formation following vascular injury [PDF]
Cardiovascular Research, 2018 Jumonji domain-containing protein 3 (JMJD3), also called lysine specific demethylase 6B (KDM6b), is an inducible histone demethylase which plays an important role in many biological processes, however, its function in vascular remodelling remains unknown. We aim to demonstrate that JMJD3 mediates vascular neointimal hyperplasia following carotid injury,
XiaoLing, Luo +11 more
openaire +2 more sources
Scientific Reports, 2022 JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian regulation in plants and humans and is involved in embryonic development and cell proliferation.
Md. Saiful Islam +3 more
doaj +1 more source