Results 41 to 50 of about 6,610 (186)

Reprogramming the Epigenome With Vitamin C

Frontiers in Cell and Developmental Biology, 2019
The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs).
Taylor Lee Chong, Emily L. Ahearn, Luisa Cimmino, Luisa Cimmino   +3 more
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JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]

, 2016
JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan, Han, Jihong, Li, Luyuan, Luo, Yunping, Ren, Guosheng, Shen, Long, Stupack, Dwayne G, Tan, Xiaoyue, Xiang, Rong, Xun, Jing, Zhang, Yan   +10 more
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Therapeutic Potentials of Inhibition of Jumonji C Domaincontaining Demethylases in Acute Myeloid Leukemia

Turkish Journal of Hematology, 2020
Objective: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression.
Duygu Koca, Nurcan Haştar, Selin Engür, Yağmur Kiraz, Gizem Tuğçe Ulu, Demet Çekdemir, Yusuf Baran   +6 more
doaj   +1 more source

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism [PDF]

, 2014
Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite of enzymes are the 2-oxoglutarate/Fe(II)-dependent dioxygenases (2-ODDs). Cytochromes P450 (CYPs) as often considered the most versatile oxidative enzymes in nature,
Peter J. Facchini, Scott C. Farrow
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Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. [PDF]

, 2020
Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
Choi, Yoon, Nguyen, Hai, SUL, Hei Sook, Viscarra, Jose, Wang, Yuhui   +4 more
core  

JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators [PDF]

, 2015
A schematic representation showing the genomic regions of the three genes for ChIP-PCR assay. White box indicates untranslated region, black box indicates coding sequence, line through the box indicates intron region of the genes, lines and numbers above
Jian Zhang, Lei Sun, Lianmeng Liu, Ling Wang, Liyuan Wang, Lu Li, Qiong Rao, Shiwen Huang, Yuxuan Hou   +8 more
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Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics

Toxicology Reports, 2014
Background: Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence.
Divya Teja Vavilala, Sujatha Reddy, Sachchidanand, Swami Prakash, V.K. Chaithanya Ponnaluri, Arvind Kumar, Mridul Mukherji   +6 more
doaj   +1 more source

HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

Cellular & Molecular Biology Letters, 2021
Background Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia regulatory protein.
Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang, Weiheng Wen, Weiqiang Jiang, Hong Chen, Donghui Liang, Jia Sun, Ming Wang   +9 more
doaj   +1 more source

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia [PDF]

, 2013
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options.
A Subramanian, A Tsirigos, AA Mansour, Adolfo A. Ferrando, Alexandros Strikoudis, AM Jankowska, AP Weng, Aristotelis Tsirigos, B King, B Langmead, BG Mar, Bryan King, C Morales Torres, C Simon, C Wang, CG Mullighan, CG Mullighan, Charles G. Mullighan, DI Marks, Elisabeth Paietta, Evangelia Loizou, F Armstrong, F De Santa, G van Haaften, G. Grant Welstead, GG Welstead, Giovanni Tonon, GL Sen, H Wang, Iannis Aifantis, J Zhang, J Zhang, Jacob M. Rowe, Jared Becksfort, Jasper Mullenders, Jelena Nedjic, JK Wang, K Agger, K Chen, K Jepsen, L Espinosa, L Kruidenier, L Wang, Laurens Kruidenier, Linda Holmfeldt, Luyao Xu, M Barradas, Martin S. Tallman, MR Hubner, P Ntziachristos, P Van Vlierberghe, Panagiotis Ntziachristos, Pieter Van Vlierberghe, PJ Valk, Q Li, RA Dickins, Rab Prinjha, RG Verhaak, Rudolf Jaenisch, S Thieme, S Zhong, SB Baylin, Shizuo Akira, SM Kooistra, Sofia Bakogianni, T Palomero, T Satoh, Takashi Satoh, Thomas Trimarchi, VM Sharma, W Zhao, WA Dik, Y Zhang   +72 more
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Epigenetic polypharmacology: from combination therapy to multitargeted drugs [PDF]

, 2016
The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target.
A Anighoro, A Dey, A Ganesan, A Mai, A Nudelman, AF Fliri, B Al-Lazikani, B Knoechel, B Meunier, BC Smith, BC Smith, BC Smith, BE Gryder, C Choudhary, C Corminboeuf, C Liu, C Qian, C Tang, C Yu, C Zwergel, C-W Chen, CM Fillmore, CM Grozinger, CY Fong, D Bixby, D Gallenkamp, D Matei, D Passarella, D Rotili, D Sharma, DA Mele, E Bicaku, E Borretto, E Nicodeme, F Sun, F-W Peng, G Zhang, G-L Chen, GE Winter, GL Verdine, H Patel, HS Bandukwala, HS Takhar, J Fischer, J Lu, J Schneider, J Zhao, J Zuber, J-B Chen, J-F Couture, J-PJ Issa, JC Culhane, JL Avalos, JM Burg, JS Kirk, K Agger, K Chen, K K-p, K Pruitt, K Zhao, KB Daniel, KT Thurn, L Chen, L Chen, LK Gediya, M Buchwald, M De los Santos, M Yang, M Zuo, MA Dawson, MA Dawson, MA Park, MB Poulin, MC Chen, MJ Keiser, MM Singh, MS Finnin, N Geva-Zatorsky, OW Rokhlin, P Anand, P Bamborough, P Filippakopoulos, P Hu, P Hu, P Jones, P Rathert, PA Marks, PK Mazur, PN Munster, Q Wang, R Anand, R Morphy, R Morphy, R Nimmanapalli, R Pereira, R Pili, R Álvarez, RA Copeland, RA Juergens, RL Momparler, S Daujat, S Klimasauskas, S Mahboobi, S Mahboobi, S Zhao, SC Hodawadekar, SJ Atkinson, SS Ng, T Beckers, T Finkel, T Kokkola, T Qiu, T Vaissiere, T-G Lee, TH Luu, TJ Galloway, TM Pitts, W Guerrant, WF Hawse, X Cai, X Cheng, X Sun, X Zhang, Y Ling, Y Zhang, Z Chen   +125 more
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