Results 61 to 70 of about 6,610 (186)

Position-effect variegation revisited: HUSHing up heterochromatin in human cells. [PDF]

, 2016
Much of what we understand about heterochromatin formation in mammals has been extrapolated from forward genetic screens for modifiers of position-effect variegation (PEV) in the fruit fly Drosophila melanogaster.
Lehner, Paul J, Tchasovnikarova, Iva A, Timms, Richard T   +2 more
core   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Vitamin D and the Epigenome

Frontiers in Physiology, 2014
Epigenetic mechanisms play a crucial role in regulating gene expression. The main mechanisms involve methylation of DNA and covalent modifications of histones by methylation, acetylation, phosphorylation, or ubiquitination.
Irfete S. Fetahu, Julia eHöbaus, Enikö eKallay   +2 more
doaj   +1 more source

Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development [PDF]

, 2018
Background: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3).
A Meissner, A Schedl, AH Monsoro-Burq, AI Agulnik, AJ Bannister, AM Hever, AM Session, Beom-Sik Kang, CB Santos-Rebouças, Chowon Kim, CM Jones, D Meulemans, D Zhang, DJ Montell, Dong-Seok Lee, EL Malloch, FA Mic, FA Seigfried, G Giudetti, G Lupo, G Lupo, G Sun, H Hamada, HB Sarnat, Hyun-Kyung Lee, Hyun-Shik Lee, J Shi, J Xu, Jeen-Woo Park, JR Whetstine, KL Vermillion, Kujin Kwon, LM Kiem, LP Blair, LR Jensen, M O’Donnell, M Rothe, M Scandaglia, M Simoes-Costa, M Tahiliani, M Weider, MD Franco, MD Robinson, MJ Boland, ML Basch, ML Dirksen, MS Mimoto, N Davis-Silberman, N Saint-Germain, ND Hopwood, Oh-Shin Kwon, P Noisa, PH Mathers, PM Kulesa, R Mayor, R Mayor, RD Kortschak, RJ Klose, S Iwase, S Iwase, T Jenuwein, T Kunisada, Tae Joo Park, Taejoon Kwon, Tayaba Ismail, TJ Bailey, W Cizelsky, X Shi, X Yang, Y Aoki, Y Tsukada, Youngeun Jeong, Youni Kim, Z Chen, ZF Chen   +74 more
core   +3 more sources

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B. [PDF]

, 2018
Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical
Al Labban, D., Bongiovanni, M., Dotto, G.P., Jo, S.H., Ostano, P., Panizzon, R., Saglietti, C.   +6 more
core   +2 more sources

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy [PDF]

, 2016
Drawing of Object No ...
Ludovica Morera, Michael Lübbert, Manfred Jung   +2 more
core   +1 more source

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

European Journal of Medicinal Chemistry, 2019
Residues in the histone substrate binding sites that differ between the KDM4 and KDM5 subfamilies were identified. Subsequently, a C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one series was designed to rationally exploit these residue differences between the histone substrate binding sites in order to improve affinity for the KDM4-subfamily over KDM5 ...
Le Bihan, Yann-Vaï, Lanigan, Rachel M, Atrash, Butrus, McLaughlin, Mark G, Velupillai, Srikannathasan, Malcolm, Andrew G, England, Katherine S, Ruda, Gian Filippo, Mok, N Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M, Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I, Fedorov, Oleg, Brennan, Paul E, Burke, Rosemary, van Montfort, RobL M, Rossanese, Olivia W, Blagg, Julian, Bavetsias, Vassilios   +28 more
openaire   +5 more sources