Results 71 to 80 of about 6,610 (186)

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia [PDF]

, 2017
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown.
Chae, Sehyun, Hwang, Daehee, Lee, Ho-Youl, Lee, Jieon, Lee, Seongyeol, Moon, Yunwon, Park, Bongju, Park, Hyunsung, Yang, Eun Gyeong   +8 more
core   +2 more sources

The Role of Histone Modifications in Plant Priming and Their Analysis by Chromatin Immunoprecipitation

Physiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley   +1 more source

Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]

, 2013
Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
core   +2 more sources

Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investigated how high glucose levels influence BMSC differentiation, proliferation, viability, and metabolism ...
Suzanna Shirazi, Ezaldeen Esawi, Zeyad D. Nassar, Stan Gronthos, Dimitrios Cakouros   +4 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana [PDF]

, 2014
Citation: Wang, X., Chen, J., Xie, Z., Liu, S., Nolan, T., Ye, H., et al. (2014). Histone lysine methyltransferase SDG8 is involved in brassinosteroid- regulated gene expression in arabidopsis thaliana.The plant steroid hormones, brassinosteroids (BRs),
Chen, Jiani, Guo, Hongqing, Li, Zhaohu, Liu, Sanzhen, Nolan, Trevor, Schnable, Patrick S., Wang, Xiaolei, Xie, Zhouli, Ye, Huaxun, Yin, Yanhai, Zhang, Mingcai   +10 more
core   +1 more source

Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications

Cell Death and Disease
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis.
Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, So Hee Kwon   +4 more
doaj   +1 more source

Histone Methylation in the Nervous System: Functions and Dysfunctions [PDF]

, 2018
Chromatin remodeling is a key epigenetic process controlling the regulation of gene transcription. Local changes of chromatin architecture can be achieved by post-translational modifications of histones such as methylation, acetylation, phosphorylation ...
Jacob, Claire, Pattaroni, Céline
core  

Undercover: Gene control by metabolites and metabolic enzymes [PDF]

, 2016
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der, Verrijzer, C.P. (Peter)   +1 more
core   +2 more sources