Results 1 to 10 of about 22,032 (210)

Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence [PDF]

BMC Evolutionary Biology, 2008
Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
doaj   +4 more sources

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva, Csankovszki, Gyorgyi, Hahn, Matthias, Hake, Sandra B., Jack, Antonia P. M., Pünzeler, Sebastian, Schotta, Gunnar, Snyder, Martha, Solovei, Irina, Wells, Michael   +9 more
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Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, 2023
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
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A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance

Frontiers in Pharmacology, 2022
Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological ...
Guan-Jun Yang, Guan-Jun Yang, Guan-Jun Yang, Yan-Jun Liu, Li-Jian Ding, Fan Tao, Ming-Hui Zhu, Zhen-Yuan Shi, Juan-Ming Wen, Meng-Yao Niu, Xiang Li, Zhan-Song Xu, Wan-Jia Qin, Chen-Jie Fei, Chen-Jie Fei, Chen-Jie Fei, Jiong Chen, Jiong Chen, Jiong Chen   +18 more
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Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
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Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

PLoS Genetics, 2021
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair.
Xiaojuan Zhang, Sisi Tian, Sara E Beese-Sims, Jingjie Chen, Nara Shin, Monica P Colaiácovo, Hyun-Min Kim   +6 more
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Frontiers in Immunology, 2023
Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong, Jiaxing Zhu, Anyi Deng, Junping Wei, Jiawei Li, Xinru Mao, Zhenghu Jia, Zhenghu Jia, Zhenghu Jia   +8 more
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Histone H4K20 Demethylation by Two hHR23 Proteins

Cell Reports, 2020
Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen   +13 more
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Involvement of JMJ15 in the dynamic change of genome-wide H3K4me3 in response to salt stress

Frontiers in Plant Science, 2022
Post-translational histone modifications play important roles in regulating chromatin structure and transcriptional regulation. Histone 3 lysine 4 trimethylation (H3K4me3) is a prominent histone modification mainly associated with gene activation.
Yuan Shen, Yuhao Chi, Shun Lu, Huijuan Lu, Lei Shi   +4 more
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PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
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