Results 1 to 10 of about 29,527 (154)
JMJD3 is a histone H3K27 demethylase [PDF]
Cell Research, 2007 Histone methylation is an important epigenetic phenomenon that participates in a diverse array of cellular processes and has been found to be associated with cancer. Recent identification of several histone demethylases has proved that histone methylation is a reversible process.
Ziqi Zhu, Hanqing Lin, Gang Han
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The histone demethylase dLsd1 regulates organ size by silencing transposable elements [PDF]
Communications BiologyThe specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown.
Ines Selmi +9 more
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Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
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The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
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Frontiers in Pharmacology, 2022 Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most diagnosed cancer worldwide since 2020. Histone methylation is a common biological epigenetic modification mediating varieties of physiological and pathological ...
Guan-Jun Yang +18 more
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Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
PLoS Genetics, 2021 Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair.
Xiaojuan Zhang +6 more
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
Frontiers in Immunology, 2023 Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong +8 more
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Histone H4K20 Demethylation by Two hHR23 Proteins
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
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Involvement of JMJ15 in the dynamic change of genome-wide H3K4me3 in response to salt stress
Frontiers in Plant Science, 2022 Post-translational histone modifications play important roles in regulating chromatin structure and transcriptional regulation. Histone 3 lysine 4 trimethylation (H3K4me3) is a prominent histone modification mainly associated with gene activation.
Yuan Shen +4 more
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The emerging role of KDM5A in human cancer
Journal of Hematology & Oncology, 2021 Histone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulation, and epigenetic inheritance.
Guan-Jun Yang +7 more
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