Results 1 to 10 of about 257,789 (305)

Computational assessment of the relationship between metabolism and histone methylation in cancer cells. [PDF]

PLoS ONE
Aberrant histone methylation and metabolic alterations are key hallmarks of cancer. Metabolic reprogramming during tumorigenesis could impact the histone methylation pattern by altering the availability of substrates and cofactors required for histone ...
Mohammad Rasouli Koohi, Mahya Mehrmohamadi   +1 more
doaj   +2 more sources

Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells [PDF]

International Journal of Oral Science
Dental mesenchymal stem cells (DMSCs) are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ...
Meijun Hu, Zhipeng Fan
doaj   +2 more sources

Methylation hallmarks on the histone tail as a linker of osmotic stress and gene transcription

Frontiers in Plant Science, 2022
Plants dynamically manipulate their gene expression in acclimation to the challenging environment. Hereinto, the histone methylation tunes the gene transcription via modulation of the chromatin accessibility to transcription machinery.
Mu Xiao, Jinbiao Wang, Fang Xu
doaj   +1 more source

Histone arginine methylation [PDF]

FEBS Letters, 2010
Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the core histone tails play in regulating chromatin function.
Di Lorenzo, Alessandra, Bedford, Mark T.
openaire   +2 more sources

Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2021
The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang, Ying Luan, Rui-Xia Yuan, Yi Luan   +3 more
doaj   +1 more source

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
core   +3 more sources

Lysine methylation: beyond histones [PDF]

Acta Biochimica et Biophysica Sinica, 2012
Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics. Combinations of different modifications on the histone proteins, termed 'histone code' in many cases, extend the information potential of the genetic code by regulating
Xi, Zhang, Hong, Wen, Xiaobing, Shi
openaire   +2 more sources

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva, Csankovszki, Gyorgyi, Hahn, Matthias, Hake, Sandra B., Jack, Antonia P. M., Pünzeler, Sebastian, Schotta, Gunnar, Snyder, Martha, Solovei, Irina, Wells, Michael   +9 more
core   +7 more sources

Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells. [PDF]

PLoS ONE, 2016
Bacterial lipopolysaccharide (LPS) induces release of inflammatory mediators both in immune and epithelial cells. We investigated whether changes of epigenetic marks, including selected histone modification and DNA methylation, may drive or accompany the
Tiziana Angrisano, Raffaela Pero, Mariarita Brancaccio, Lorena Coretti, Ermanno Florio, Antonio Pezone, Viola Calabrò, Geppino Falco, Simona Keller, Francesca Lembo, Vittorio Enrico Avvedimento, Lorenzo Chiariotti   +11 more
doaj   +1 more source

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]

, 2013
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman, Du, Jiamu, Feng, Suhua, Jacobsen, Steven E, Johnson, Lianna, Patel, Dinshaw J, Stroud, Hume, Zhong, Xuehua   +7 more
core   +2 more sources