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Computational assessment of the relationship between metabolism and histone methylation in cancer cells. [PDF]
PLoS ONEAberrant histone methylation and metabolic alterations are key hallmarks of cancer. Metabolic reprogramming during tumorigenesis could impact the histone methylation pattern by altering the availability of substrates and cofactors required for histone ...
Mohammad Rasouli Koohi +1 more
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DNA methylation pathways and their crosstalk with histone methylation [PDF]
Nature Reviews Molecular Cell Biology, 2015 Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division.
Steven Jacobsen +2 more
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Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells [PDF]
International Journal of Oral ScienceDental mesenchymal stem cells (DMSCs) are pivotal for tooth development and periodontal tissue health and play an important role in tissue engineering and regenerative medicine because of their multidirectional differentiation potential and self-renewal ...
Meijun Hu, Zhipeng Fan
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Methylation hallmarks on the histone tail as a linker of osmotic stress and gene transcription
Frontiers in Plant Science, 2022 Plants dynamically manipulate their gene expression in acclimation to the challenging environment. Hereinto, the histone methylation tunes the gene transcription via modulation of the chromatin accessibility to transcription machinery.
Mu Xiao, Jinbiao Wang, Fang Xu
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Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2021 The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang +3 more
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Histone arginine methylation [PDF]
FEBS Letters, 2010 Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the core histone tails play in regulating chromatin function.
Di Lorenzo, Alessandra, Bedford, Mark T.
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Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells. [PDF]
PLoS ONE, 2016 Bacterial lipopolysaccharide (LPS) induces release of inflammatory mediators both in immune and epithelial cells. We investigated whether changes of epigenetic marks, including selected histone modification and DNA methylation, may drive or accompany the
Tiziana Angrisano +11 more
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Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]
Molecular Endocrinology, 2005 Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
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G3: Genes, Genomes, Genetics, 2016 Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu +2 more
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Redox Biology, 2021 Preterm birth is still a major health problem and maternal inflammation has been shown to play a role. The combination of maternal inflammation and neonatal hyperoxia contributes to epigenetic changes that influence gene expression and the development of
Sophia S. Sugar +4 more
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