Results 11 to 20 of about 166,151 (260)
The Role of Cotranscriptional Histone Methylations [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2010 The carboxy-terminal domain (CTD) of the RNA polymerase II subunit Rpb1 undergoes dynamic phosphorylation, with different phosphorylation sites predominating at different stages of transcription. Our laboratory studies show how various mRNA-processing and chromatin-modifying enzymes interact with the phosphorylated CTD to efficiently produce mRNAs. The
S, Buratowski, T, Kim
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BMC Plant Biology, 2010 Background Modifications of DNA and histones in various combinations are correlated with many cellular processes. In this study, we investigated the possible relationship between histone H4 tetraacetylation, DNA methylation and histone H3 dimethylation ...
Yang Fei +7 more
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DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis
Genome Biology, 2022 Background It is challenging to determine the effect of DNA methylation on the epigenetic landscape and the function in higher organisms due to the lack of DNA methylation-free mutants.
Lun Zhao +6 more
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Mimicking Methylated Histones [PDF]
ACS Chemical Biology, 2007 Histones with specific patterns of lysine methylation help to define how their associated DNA is used. A recent semisynthetic strategy for generating histone proteins that contain methyl-lysine analogues at specific sites will provide researchers with the materials to further elucidate the role of these modifications.
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Selective targeting of histone methylation [PDF]
Cell Cycle, 2011 Histones are post-translationally modified by multiple histone-modifying enzymes, which in turn influences gene expression. Much of the work in the field to date has focused on genetic, biochemical and structural characterization of these enzymes.
Abul B M M K, Islam +3 more
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PLoS ONE, 2020 Methionine (Met) is an essential precursor of S-adenosylmethionine (SAM), which is the primary methyl donor required for biological processes such as DNA and histone methylation, which alter gene expression.
Fernanda Rosa, Johan S Osorio
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Histone methylation and vascular biology [PDF]
Clinical Epigenetics, 2020 AbstractThe vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain homeostasis within the vasculature. Recent studies have greatly expanded our understanding of the regulation of vasculature development and ...
Xiang Wei +3 more
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Research progress on histone acetylation/methylation in oral diseases [PDF]
口腔疾病防治Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities. Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.
LUO Yuchuan, LI Feifei, YU Fanyuan, YIN Bei, YE Ling
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Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges
Computational and Structural Biotechnology Journal, 2018 Lung cancer is one of the most common malignancies. In spite of the progress made in past decades, further studies to improve current therapy for lung cancer are required.
Yuchen Chen +5 more
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Lysine methylation: beyond histones [PDF]
Acta Biochimica et Biophysica Sinica, 2012 Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics. Combinations of different modifications on the histone proteins, termed 'histone code' in many cases, extend the information potential of the genetic code by regulating
Xi, Zhang, Hong, Wen, Xiaobing, Shi
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