Results 41 to 50 of about 166,151 (260)

Aberrant Histone Methylation in Patients with Graves’ Disease

International Journal of Endocrinology, 2019
Background. Graves’ disease (GD) is an organ-specific autoimmune disease. Accumulated data have indicated that aberrant epigenetic modifications are associated with many autoimmune disorders.
Ni Yan, Kaida Mu, Xiao-fei An, Ling Li, Qiu Qin, Rong-hua Song, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang   +8 more
doaj   +1 more source

Interactions between core histone marks and DNA methyltransferases predict DNA methylation patterns observed in human cells and tissues

Epigenetics, 2020
DNA methylation and histone modifications are two major epigenetic marks in mammalian cells. Previous studies have revealed that these two mechanisms interact although a quantitative model of these is still lacking in mammalian cells.
Kai Fu, Giancarlo Bonora, Matteo Pellegrini   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Tackling malignant melanoma epigenetically: histone lysine methylation

Clinical Epigenetics, 2018
Post-translational histone modifications such as acetylation and methylation can affect gene expression. Histone acetylation is commonly associated with activation of gene expression whereas histone methylation is linked to either activation or ...
Elias Orouji, Jochen Utikal
doaj   +1 more source

Controlling histone methylation via trans-histone pathways [PDF]

Epigenetics, 2008
Covalent post-translational modifications of histones have been demonstrated to participate in a wide array of cellular processes, including regulation of gene transcription, gene repression, DNA double strand break repair and mitosis. Regulation of how these covalent modifications, and the implications of this regulation, are currently of great ...
Ian M, Fingerman, Hai-Ning, Du, Scott D, Briggs   +2 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

Cell Reports, 2016
DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem ...
Andrew D. King, Kevin Huang, Liudmilla Rubbi, Shuo Liu, Cun-Yu Wang, Yinsheng Wang, Matteo Pellegrini, Guoping Fan   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms

Frontiers in Cell and Developmental Biology, 2022
Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have ...
Sara E. DiNapoli, Sara E. DiNapoli, Raúl Martinez-McFaline, Raúl Martinez-McFaline, Hao Shen, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Isabel Nelson, Courtney A. Balgobin, Courtney A. Balgobin, Caitlin T. Bourque, Caitlin T. Bourque, Jun Yao, Jun Yao, Renuka Raman, Renuka Raman, Wendy Béguelin, Wendy Béguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Ari M. Melnick, Yariv Houvras, Yariv Houvras, Yariv Houvras   +28 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source