Results 51 to 60 of about 166,151 (260)

Histone Methyltransferase Assay in vitro

Bio-Protocol, 2012
Histone methylation is an important epigenetic modification that plays important roles in plant development and growth. Histone methytransferases are the enzymes to establish histone methylation and here we describe a simple and effective protocol for ...
Pengfei Sui, Yu Yu, Aiwu Dong
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis

Journal of Lipid and Atherosclerosis, 2020
Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic
Han-Teo Lee, Sanghyeon Oh, Du Hyun Ro, Hyerin Yoo, Yoo-Wook Kwon   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Computational micromodel for epigenetic mechanisms. [PDF]

PLoS ONE, 2010
Characterization of the epigenetic profile of humans since the initial breakthrough on the human genome project has strongly established the key role of histone modifications and DNA methylation.
Karthika Raghavan, Heather J Ruskin, Dimitri Perrin, Francois Goasmat, John Burns   +4 more
doaj   +1 more source

Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion

Redox Biology, 2023
At physiological levels, the trace element selenium plays a key role in redox reactions through the incorporation of selenocysteine in antioxidant enzymes.
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan   +14 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

Scientific Reports, 2017
Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to DNA methylation sites.
Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi   +8 more
doaj   +1 more source

Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia

Journal of Hematology & Oncology, 2012
Background We have previously studied the histone acetylation in primary human leukemia cells. However, histone H3 methylation in these cells has not been characterized. Methods This study examined the methylation status at histone H3 lysine 4 (H3K4) and
Zou Yong, Ma Xudong, Huang Yiqun, Hong Lingling, Chiao Jen-wei   +4 more
doaj   +1 more source