Results 51 to 60 of about 257,789 (305)

Selective targeting of histone methylation [PDF]

Cell Cycle, 2011
Histones are post-translationally modified by multiple histone-modifying enzymes, which in turn influences gene expression. Much of the work in the field to date has focused on genetic, biochemical and structural characterization of these enzymes.
Abul B M M K, Islam, William F, Richter, Nuria, Lopez-Bigas, Elizaveta V, Benevolenskaya   +3 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A convolutional neural network-based regression model to infer the epigenetic crosstalk responsible for CG methylation patterns

BMC Bioinformatics, 2021
Background Epigenetic modifications, including CG methylation (a major form of DNA methylation) and histone modifications, interact with each other to shape their genomic distribution patterns.
Wan Kin Au Yeung, Osamu Maruyama, Hiroyuki Sasaki   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Tackling malignant melanoma epigenetically: histone lysine methylation

Clinical Epigenetics, 2018
Post-translational histone modifications such as acetylation and methylation can affect gene expression. Histone acetylation is commonly associated with activation of gene expression whereas histone methylation is linked to either activation or ...
Elias Orouji, Jochen Utikal
doaj   +1 more source

Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification. [PDF]

PLoS Genetics, 2012
Non-coding transcription can trigger histone post-translational modifications forming specialized chromatin. In fission yeast, heterochromatin formation requires RNAi and the histone H3K9 methyltransferase complex CLRC, composed of Clr4, Raf1, Raf2, Cul4,
Alessia Buscaino, Sharon A White, Douglas R Houston, Erwan Lejeune, Femke Simmer, Flavia de Lima Alves, Piyush T Diyora, Takeshi Urano, Elizabeth H Bayne, Juri Rappsilber, Robin C Allshire   +10 more
doaj   +1 more source

Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms

Frontiers in Cell and Developmental Biology, 2022
Perturbations to the epigenome are known drivers of tumorigenesis. In melanoma, alterations in histone methyltransferases that catalyze methylation at histone 3 lysine 9 and histone 3 lysine 27—two sites of critical post-translational modification—have ...
Sara E. DiNapoli, Sara E. DiNapoli, Raúl Martinez-McFaline, Raúl Martinez-McFaline, Hao Shen, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Isabel Nelson, Courtney A. Balgobin, Courtney A. Balgobin, Caitlin T. Bourque, Caitlin T. Bourque, Jun Yao, Jun Yao, Renuka Raman, Renuka Raman, Wendy Béguelin, Wendy Béguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Ari M. Melnick, Yariv Houvras, Yariv Houvras, Yariv Houvras   +28 more
doaj   +1 more source

Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]

Molecular Endocrinology, 2005
Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Aberrant Histone Methylation in Patients with Graves’ Disease

International Journal of Endocrinology, 2019
Background. Graves’ disease (GD) is an organ-specific autoimmune disease. Accumulated data have indicated that aberrant epigenetic modifications are associated with many autoimmune disorders.
Ni Yan, Kaida Mu, Xiao-fei An, Ling Li, Qiu Qin, Rong-hua Song, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang   +8 more
doaj   +1 more source