Results 31 to 40 of about 257,789 (305)
Histone Methylation in Myelodysplastic Syndromes [PDF]
Epigenomics, 2011 Histone methylation is a type of epigenetic modification that is critical for the regulation of gene expression. Numerous studies have demonstrated that abnormalities of this newly characterized epigenetic modification are involved in the development of multiple diseases, including cancer.
Yue, Wei +4 more
openaire +2 more sources
Targeting histone methylation for colorectal cancer
Therapeutic Advances in Gastroenterology, 2017 As a leading cause of cancer deaths worldwide, colorectal cancer (CRC) results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in CRC, particularly aberrant histone methylation mediated by histone ...
Tao Huang +7 more
doaj +1 more source
BMC Plant Biology, 2009 Background Histone modifications and histone variants are of importance in many biological processes. To understand the biological functions of the global dynamics of histone modifications and histone variants in higher plants, we elucidated the variants
Lam Hon-Ming +6 more
doaj +1 more source
Frontiers in Immunology, 2023 Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment ...
Yuanling Zhang +9 more
doaj +1 more source
dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. [PDF]
, 2017 Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that ...
Farnham, Peggy J +8 more
core +2 more sources
Histone methylation and vascular biology [PDF]
Clinical Epigenetics, 2020 AbstractThe vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain homeostasis within the vasculature. Recent studies have greatly expanded our understanding of the regulation of vasculature development and ...
Xiang Wei +3 more
openaire +2 more sources
Exaggerated CpH methylation in the autism-affected brain. [PDF]
, 2017 BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E +4 more
core +1 more source
PLoS ONE, 2014 Epigenetic marks such as histone modifications play roles in various chromosome dynamics in mitosis and meiosis. Methylation of histones H3 at positions K4 and K79 is involved in the initiation of recombination and the recombination checkpoint ...
Mohammad Bani Ismail +2 more
doaj +1 more source
Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line. [PDF]
PLoS ONE, 2010 Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development.
Maren Godmann, Erin May, Sarah Kimmins
doaj +1 more source
Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]
, 2019 Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong +6 more
core +1 more source