Results 21 to 30 of about 166,151 (260)
Targeting histone methylation for colorectal cancer
Therapeutic Advances in Gastroenterology, 2017 As a leading cause of cancer deaths worldwide, colorectal cancer (CRC) results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in CRC, particularly aberrant histone methylation mediated by histone ...
Tao Huang +7 more
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Journal of Hematology & Oncology, 2016 Post-translational methylation of histone lysine or arginine residues plays important roles in gene regulation and other physiological processes. Aberrant histone methylation caused by a gene mutation, translocation, or overexpression can often lead to ...
Yongcheng Song, Fangrui Wu, Jingyu Wu
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Histone Methylation in Myelodysplastic Syndromes [PDF]
Epigenomics, 2011 Histone methylation is a type of epigenetic modification that is critical for the regulation of gene expression. Numerous studies have demonstrated that abnormalities of this newly characterized epigenetic modification are involved in the development of multiple diseases, including cancer.
Yue, Wei +4 more
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BMC Plant Biology, 2009 Background Histone modifications and histone variants are of importance in many biological processes. To understand the biological functions of the global dynamics of histone modifications and histone variants in higher plants, we elucidated the variants
Lam Hon-Ming +6 more
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Frontiers in Immunology, 2023 Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment ...
Yuanling Zhang +9 more
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PLoS ONE, 2014 Epigenetic marks such as histone modifications play roles in various chromosome dynamics in mitosis and meiosis. Methylation of histones H3 at positions K4 and K79 is involved in the initiation of recombination and the recombination checkpoint ...
Mohammad Bani Ismail +2 more
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A Crack in Histone Lysine Methylation [PDF]
Cell, 2004 Histone lysine methylation is regarded as a very stable modification with important functions in epigenetic gene control and for organizing chromatin domains. While more robust modifications of the chromatin template are essential to stabilize epigenetic information, there is now the first evidence for a histone lysine demethylase that reverts an ...
Kubicek, Stefan, Jenuwein, Thomas
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Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line. [PDF]
PLoS ONE, 2010 Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development.
Maren Godmann, Erin May, Sarah Kimmins
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BMC Genomics, 2019 Background During decidualization in endometrial stromal cells (ESCs), expressions of a number of genes and epigenetic modifications of histones are altered.
Ryo Maekawa +8 more
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Global lysine methylome profiling using systematically characterized affinity reagents
Scientific Reports, 2023 Lysine methylation modulates the function of histone and non-histone proteins, and the enzymes that add or remove lysine methylation—lysine methyltransferases (KMTs) and lysine demethylases (KDMs), respectively—are frequently mutated and dysregulated in ...
Christine A. Berryhill +7 more
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