Results 1 to 10 of about 38,510 (187)
The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a) [PDF]
Journal of Structural Biology: X, 2021 Euchromatic histone-lysine N-methyltransferase 1 (EHMT1; G9a-like protein; GLP) and euchromatic histone-lysine N-methyltransferase 2 (EHMT2; G9a) are protein lysine methyltransferases that regulate gene expression and are essential for development and ...
Keshia M. Kerchner +5 more
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Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer [PDF]
Molecular Oncology, 2023 Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone‐lysine N‐methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including HCC.
Dexter Kai Hao Thng +17 more
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mBio, 2023 Legionella pneumophila is a bacterial pathogen ubiquitous in natural and man-made aquatic environments, where it replicates in protozoa. Its intracellular life cycle depends on the establishment of a Legionella-containing vacuole (LCV) where the bacteria
Monica Rolando +6 more
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Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells
Cell Death Discovery, 2022 Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2 mediated epigenetic regulation of embryonic differentiation and development is quite unknown.
Sureshkumar Perumal Srinivasan +6 more
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Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2/3. [PDF]
PLoS ONE, 2012 SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1
Tao Wang +12 more
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Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases
Frontiers in Physiology, 2021 Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme that catalyzes the addition of methyl groups to histone H3 at lysine 27, leading to gene silencing.
Tingting Li +3 more
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Journal of Experimental & Clinical Cancer Research, 2021 Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge.
Shangwei Zhong +7 more
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Frontiers in Cell and Developmental Biology, 2021 Congenital heart defects are the most common birth defect and have a clear genetic component, yet genomic structural variations or gene mutations account for only a third of the cases.
Fengling Chen +12 more
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Gut and Liver, 2019 Background/Aims Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after treatment.
Kyong-Ah Yoon +8 more
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N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing. [PDF]
PLoS Genetics, 2013 Post-translational modifications of histones play a key role in DNA-based processes, like transcription, by modulating chromatin structure. N-terminal acetylation is unique among the numerous histone modifications because it is deposited on the N-alpha ...
Vassia Schiza +4 more
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