Results 11 to 20 of about 38,510 (187)

The Histone‐Lysine N‐Methyltransferase (KMT2) Family in Health and Disease [PDF]

MedComm
The histone‐lysine N‐methyltransferase (KMT2) family is a central epigenetic regulator whose dysfunction drives diverse human diseases through distinct molecular mechanisms.
Qiu Wang, Zunjie Bo, Ya Zhang, Yun Chen, Zhiyu Wang, Shuangmei Tong, Ajing Xu, Jian Zhang, Yan Liu   +8 more
doaj   +2 more sources

Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients [PDF]

EBioMedicine, 2018
Background: There is an urgent need for the identification of new, clinically useful biomarkers of CRC to enhance diagnostic and prognostic capabilities.
Baojun Duan, Jun Bai, Jian Qiu, Jianhua Wang, Cong Tong, Xiaofei Wang, Jiyu Miao, Zongfang Li, Wensheng Li, Juan Yang, Chen Huang   +10 more
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Role of histone-lysine N-methyltransferase 2D (KMT2D) in MEK-ERK signaling-mediated epigenetic regulation: a phosphoproteomics perspective [PDF]

Frontiers in Bioinformatics
IntroductionHistone-lysine N-methyltransferase 2D (KMT2D) is an H3K4 methyltransferase and a potential tumor suppressor with a crucial role in regulating gene expression.
Sreeshma Ravindran Kammarambath, Leona Dcunha, Athira Perunelly Gopalakrishnan, Amal Fahma, Neelam Krishna, Altaf Mahin, Samseera Ummar, Prathik Basthikoppa Shivamurthy, Inamul Hasan Madar, Rajesh Raju   +9 more
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Structural insights into the C-terminus of the histone-lysine N-methyltransferase NSD3 by small-angle X-ray scattering [PDF]

Frontiers in Molecular Biosciences
NSD3 is a member of six H3K36-specific histone lysine methyltransferases in metazoans. Its overexpression or mutation is implicated in developmental defects and oncogenesis.
Benny Danilo Belviso, Yunpeng Shen, Benedetta Carrozzini, Masayo Morishita, Eric di Luccio, Rocco Caliandro   +5 more
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EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G [PDF]

Experimental and Molecular Medicine
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) has been implicated in cardiovascular diseases, yet its role in vascular remodeling remains incompletely understood.
Zelan Wang, Junyong Zhao, Wenjian Luo, Ning Sun, Xingyu Ma, Fangyuan Zhong, Boji Wu, Heng Tang, Ke Ning, Jingyu He, Xuhong Wang, Kun Zhang, Jihang Zhang, Chuan Liu, Jun Ren, Yan Zhao, Zhexue Qin   +16 more
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Proline cis-trans isomerization is influenced by local lysine acetylation-deacetylation

Microbial Cell, 2014
Acetylation of lysine residues has several characterised functions in chromatin. These include neutralization of the lysine’s positive charge to directly influence histone tail-DNA/internucleosomal interactions or indirect effects via bromodomain ...
Françoise S. Howe, Jane Mellor
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The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.

PLoS ONE, 2016
Mixed Lineage Leukemia 5 (MLL5) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. Chromatin binding is ensured by its plant homeodomain (PHD) through a direct interaction with the N-terminus of histone H3 (H3).
Sarah Mas-Y-Mas, Marta Barbon, Catherine Teyssier, Hélène Déméné, João E Carvalho, Louise E Bird, Andrey Lebedev, Juliana Fattori, Michael Schubert, Christian Dumas, William Bourguet, Albane le Maire   +11 more
doaj   +1 more source

Design, synthesis, and biological evaluation of SMYD3 inhibitors possessing N-thiazole benzenesulfonamide moiety as potential anti-cancer agents

Journal of Saudi Chemical Society, 2022
Background: SMYD3 is a protein lysine methyltransferase that methylates lysine in histone and non-histone proteins resulting in regulation of gene transcription and cell signaling pathways.
Suaad Abdallah Audat, Nizar A. Al-Shar'i, Buthina Abdallah Al-Oudat, Soraya Alnabulsi   +3 more
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Solution NMR structure and histone binding of the PHD domain of human MLL5. [PDF]

PLoS ONE, 2013
Mixed Lineage Leukemia 5 (MLL5) is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. In addition to its catalytic domain, MLL5 contains a PHD finger domain, a protein module that is often ...
Alexander Lemak, Adelinda Yee, Hong Wu, Damian Yap, Hong Zeng, Ludmila Dombrovski, Scott Houliston, Samuel Aparicio, Cheryl H Arrowsmith   +8 more
doaj   +1 more source

KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer

Frontiers in Bioscience-Landmark, 2023
Background: The histone lysine methyltransferase Histone-lysine N-methytransferase 2D (KMT2D) is a common mutated gene in a variety of cancers, including papillary thyroid cancer (PTC).
Rui Wang, Yibo He, Yi Wang, Shangnao Xie
doaj   +1 more source