Results 1 to 10 of about 13,098 (199)

Contrasting roles of KMT2C and KMT2D in breast cancer [PDF]

Scientific Reports
KMT2C and KMT2D are paralogous lysine-methyltransferases that primarily monomethylate lysine residues at enhancer regions promoting an active transcriptional state.
Emily Tinsley, Philip Bredin, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney   +4 more
doaj   +7 more sources

Deficiency of KMT2D causes autistic-like behavior in mice and zebrafish [PDF]

Communications Biology
Kabuki syndrome type 1 is a congenital multisystem disorder caused by KMT2D mutations. While some studies suggest that KMT2D deficiency may lead to autistic-like behaviors, the role of KMT2D in social behavior remains unconfirmed due to a lack of animal ...
Huakun Shangguan, Jingguo Huang, Xia Wei, Jie Huang, Zaicheng Cao, Xingjingyan Chen, Jiahui Yuan, Jingrun Zhang, Binbin Ye, Ruofei Yan, Ruimin Chen, Wucheng Tao   +11 more
doaj   +6 more sources

Role of histone methyltransferase KMT2D in BMSC osteogenesis via AKT signaling

Regenerative Therapy
Understanding the precise mechanism of BMSC (bone marrow mesenchymal stem cell) osteogenesis is critical for metabolic bone diseases and bone reconstruction. The histone-lysine N-methyltransferase 2D (KMT2D) acts as an important methyltransferase related
Xuejun Gao
exaly   +6 more sources

Role of histone-lysine N-methyltransferase 2D (KMT2D) in MEK-ERK signaling-mediated epigenetic regulation: a phosphoproteomics perspective [PDF]

Frontiers in Bioinformatics
IntroductionHistone-lysine N-methyltransferase 2D (KMT2D) is an H3K4 methyltransferase and a potential tumor suppressor with a crucial role in regulating gene expression.
Sreeshma Ravindran Kammarambath, Leona Dcunha, Athira Perunelly Gopalakrishnan, Amal Fahma, Neelam Krishna, Altaf Mahin, Samseera Ummar, Prathik Basthikoppa Shivamurthy, Inamul Hasan Madar, Rajesh Raju   +9 more
doaj   +3 more sources

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS

Cell Reports
Summary: The histone H3 lysine 4 (H3K4) methyltransferase KMT2D (also called MLL4) is one of the most frequently mutated epigenetic modifiers in many cancers, including medulloblastoma (MB).
Shilpa Dhar, Min Gyu Lee
exaly   +4 more sources

KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

Advanced Science, 2023
KMT2C and KMT2D are the most frequently mutated epigenetic genes in human cancers. While KMT2C is identified as a tumor suppressor in acute myeloid leukemia (AML), the role of KMT2D remains unclear in this disease, though its loss promotes B cell ...
Yu Liu
exaly   +3 more sources

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression [PDF]

Mol Biomed
Castration-resistant prostate cancer (CRPC) poses a significant clinical challenge, characterized by limited therapeutic options and unfavorable prognosis, particularly among elderly men.
Haoran Wen, Maierhaba Maheremu, Kaidi Zhang, Liurui Bao, Mayao Luo, Yifan Zhang, Yuanpeng Liao, Manli Zhou, Chenwei Wu, Shidong Lv, Xiaofu Qiu, Qiang Wei   +11 more
semanticscholar   +2 more sources

Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma

Nature Communications
Histone lysine methyltransferase 2D (KMT2D) is the most frequently mutated epigenetic modifier in head and neck squamous cell carcinoma (HNSCC).
Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, Cun-Yu Wang   +10 more
doaj   +2 more sources

Preliminary investigation of the epigenetic regulation of KMT2D via H3K4me1/H3K27ac in oral squamous cell carcinoma

Cellular and Molecular Life Sciences
Histone lysine methyltransferase 2D (KMT2D/MLL4) critically modulates gene expression by methylating and acetylating histones H3K4/H3K27, thereby regulating the expression of specific target genes. Although KMT2D is highly mutated in a variety of cancers,
Mujie Yuan, Kexin Wang, Baoxing Pang, Haijun Lu, Shuai Jiang, Kai Song, Zongxuan He, Jing Deng, Jianjun Yang, Lin Wang   +9 more
doaj   +2 more sources

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Cell Reports, 2020
Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled ...
Yu-Hsi Lin, Davis Ingram, Mayinuer Maitituoheti   +2 more
exaly   +3 more sources