Results 1 to 10 of about 1,112,729 (199)

Histone modification and histone modification-targeted anti-cancer drugs in breast cancer: Fundamentals and beyond

Frontiers in Pharmacology, 2022
Dysregulated epigenetic enzymes and resultant abnormal epigenetic modifications (EMs) have been suggested to be closely related to tumor occurrence and progression.
Jianwei Feng, Xinyue Meng
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Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Frontiers in Immunology
Inflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, encompassing a ...
Lichen Zhang, Lichen Zhang, Rongrong Chai, Rongrong Chai, Zongguang Tai, Zongguang Tai, Fengze Miao, Fengze Miao, Xinwei Shi, Xinwei Shi, Zhongjian Chen, Zhongjian Chen, Quangang Zhu, Quangang Zhu   +13 more
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Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification

Mediators of Inflammation, 2022
Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs).
Tingting Zhou, Huiwen Xu, Xi Cheng, Yanqiu He, Qian Ren, Dongzhe Li, Yumei Xie, Chenlin Gao, Yuanyuan Zhang, Xiaodong Sun, Yong Xu, Wei Huang   +11 more
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A protein isolation method for western blot to study histones with an internal control protein

Journal of Advanced Biotechnology and Experimental Therapeutics, 2018
Histone modification is one of the attractive targets for epigenetic studies. However, current methods to extract chromatin-associated proteins for western blot of histone modification have some weaknesses such as the loss of housekeeping proteins.
Dinh Toi Chu, Yang Tao
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Histone Deubiquitination Assay in Nicotiana benthamiana

Bio-Protocol, 2018
Histone modifications are a group of post-translational modifications on histones which can alter chromatin structure and affect gene expression. Histone ubiquitination is a histone modification found in particular on histone H2A and H2B.
Shujing Liu, Lars Hennig
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Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma

Cancer Communications, 2023
Background Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the regulation of ...
Ai Zhuang, Xiang Gu, Tongxin Ge, Shaoyun Wang, Shengfang Ge, Peiwei Chai, Renbing Jia, Xianqun Fan   +7 more
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Involvement of histone modification in regulating CUP-SHAPED COTYLEDON genes during shoot regeneration in Arabidopsis

Biologia Plantarum, 2017
Histone modification is a ubiquitous regulator of gene transcription. Arabidopsis CUP-SHAPED COTYLEDON (CUC) genes serve as a marker for shoot apical meristem initiation, but how they are regulated during shoot regeneration from in vitro culture, it is ...
Y.-G. Song, Y.-L. Liu, N.-W. Qiu, W. Dong   +3 more
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A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover. [PDF]

PLoS Genetics, 2011
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications.
Kitty F Verzijlbergen, Tibor van Welsem, Daoud Sie, Tineke L Lenstra, Daniel J Turner, Frank C P Holstege, Ron M Kerkhoven, Fred van Leeuwen   +7 more
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Genome-wide Profiling of Histone Lysine Butyrylation Reveals its Role in the Positive Regulation of Gene Transcription in Rice

Rice, 2019
Background Histone modifications play important roles in growth and development of rice (Oryza sativa L.). Lysine butyrylation (Kbu) with a four-carbon chain is a newly-discovered histone acylation modification in rice.
Shuai Liu, Guanqing Liu, Peifeng Cheng, Chao Xue, Yong Zhou, Xu Chen, Lu Ye, Zhongying Qiao, Tao Zhang, Zhiyun Gong   +9 more
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Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer

Frontiers in Molecular Biosciences
BackgroundProstate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response.
XiaoFeng He, QinTao Ge, QinTao Ge, WenYang Zhao, Chao Yu, HuiMing Bai, XiaoTong Wu, Jing Tao, WenHao Xu, WenHao Xu, Yunhua Qiu, Lei Chen, JianFeng Yang   +12 more
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