Results 1 to 10 of about 289,022 (302)

Computational study of associations between histone modification and protein-DNA binding in yeast genome by integrating diverse information [PDF]

BMC Genomics, 2011
Background In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed.
Wang Junbai
doaj   +3 more sources

Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer [PDF]

Frontiers in Molecular Biosciences
BackgroundProstate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response.
XiaoFeng He, QinTao Ge, QinTao Ge, WenYang Zhao, Chao Yu, HuiMing Bai, XiaoTong Wu, Jing Tao, WenHao Xu, WenHao Xu, Yunhua Qiu, Lei Chen, JianFeng Yang   +12 more
doaj   +2 more sources

Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem Cells [PDF]

Biology
Histone modifications play a critical role in regulating gene expression and maintaining the functionality of spermatogonial stem cells (SSCs), which are essential for male fertility and spermatogenesis. In this study, we integrated microarray and single-
Ali Shakeri Abroudi, Hossein Azizi, Melika Djamali, Ali Qorbanee, Thomas Skutella   +4 more
doaj   +2 more sources

Optimized Tensor Decomposition and Principal Component Analysis Outperforming State-of-the-Art Methods When Analyzing Histone Modification Chromatin Immunoprecipitation Profiles

Algorithms, 2023
It is difficult to identify histone modification from datasets that contain high-throughput sequencing data. Although multiple methods have been developed to identify histone modification, most of these methods are not specific to histone modification ...
Turki Turki, Sanjiban Sekhar Roy, Y.-H. Taguchi   +2 more
doaj   +1 more source

Histones and histone modifications [PDF]

Current Biology, 2004
Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
openaire   +2 more sources

Histone Modifications in Acute Kidney Injury

Kidney Diseases, 2022
Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial.
Jun Wang, Fengchen Shen, Feng Liu, Shougang Zhuang   +3 more
doaj   +1 more source

Histone onco-modifications [PDF]

Oncogene, 2011
Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis.
J, Füllgrabe, E, Kavanagh, B, Joseph
openaire   +2 more sources

Trisomy 21 alters DNA methylation in parent-of-origin-dependent and independent manners [PDF]

, 2016
The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies.
Alves da Silva, Antônio Francisco, Biselli-Périco, Joice Matos, Chuva de Sousa Lopes, Susana Marina, Fernandes, Maria Gomes, Francisco Junior, Ronaldo da Silva, Lopes Rios, Álvaro Fabricio, Machado, Douglas Terra, Machado, Filipe Brum, Medina-Acosta, Enrique, Mozer Rodrigues, Pedro Thyago, Pavarino, Érika Cristina, Santos-Rebouças, Cíntia Barros, Zampieri, Bruna Lancia   +12 more
core   +11 more sources

The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review

Frontiers in Physiology, 2023
Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
doaj   +1 more source

The Regulation and Function of Histone Crotonylation

Frontiers in Cell and Developmental Biology, 2021
Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone ...
Angeliki Ntorla, Joseph Robert Burgoyne
doaj   +1 more source