Results 21 to 30 of about 189,008 (259)

Histone Modifications and Cancer [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
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Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Cell Discovery, 2021
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding ...
Kyle Delaney, Minjia Tan, Zhesi Zhu, Jinjun Gao, Lunzhi Dai, Sunjoo Kim, Jun Ding, Maomao He, Levon Halabelian, Lu Yang, Prabakaran Nagarajan, Mark Robert Parthun, Sangkyu Lee, Saadi Khochbin, Yujun George Zheng, Yingming Zhao   +15 more
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Frontiers in Immunology, 2023
Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong, Jiaxing Zhu, Anyi Deng, Junping Wei, Jiawei Li, Xinru Mao, Zhenghu Jia, Zhenghu Jia, Zhenghu Jia   +8 more
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Histone onco-modifications [PDF]

Oncogene, 2011
Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis.
J, Füllgrabe, E, Kavanagh, B, Joseph
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Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. [PDF]

PLoS ONE, 2016
Tumor cells become resistant after long-term use of anti-VEGF (vascular endothelial growth factor) agents. Our previous study shows that treatment with a VEGF inhibitor (VEGF-Trap) facilitates to develop tumor resistance through regulating angiogenesis ...
Dong Li, Jiejun Shi, Yanhua Du, Kaiming Chen, Zhenping Liu, Bing Li, Jie Li, Fei Tao, Hua Gu, Cizhong Jiang, Jianmin Fang   +10 more
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Transcription factors direct epigenetic reprogramming at specific loci in human cancers

Frontiers in Genetics, 2023
The characterization of epigenetic changes during cancer development and progression led to notable insights regarding the roles of cancer-specific epigenetic reprogramming.
Han Jiang, Guoxin Li
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NUCLIZE for quantifying epigenome: generating histone modification data at single-nucleosome resolution using genuine nucleosome positions

BMC Genomics, 2019
Background Defining histone modification at single-nucleosome resolution provides accurate epigenomic information in individual nucleosomes. However, most of histone modification data deposited in current databases, such as ENCODE and Roadmap, have low ...
Daoshan Zheng, Justyna Trynda, Zhifu Sun, Zhaoyu Li   +3 more
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Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]

PeerJ
Histone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du, Wanyi Luo, Liwei Zheng, Xuedong Zhou, Wei Du   +4 more
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Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila

Cells, 2022
Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian, Huijuan Hao, Jing Xu, Tao Bo, Wei Wang   +4 more
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Computational study of associations between histone modification and protein-DNA binding in yeast genome by integrating diverse information

BMC Genomics, 2011
Background In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed.
Wang Junbai
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