Results 1 to 10 of about 206,586 (259)

Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription

Nature Communications
In all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated.
Tim Liebner, Sinan Kilic, Jonas Walter, Hitoshi Aibara, Takeo Narita, Chunaram Choudhary   +5 more
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The Epigenetic Landscape of Pancreatic Cancer Stem Cells

Epigenomes, 2018
Data now indicates that in addition to genetic alterations/mutations, human cancer cells exhibit important changes in their epigenome. In the context of this review, we define the epigenome as the chemical compounds and/or proteins that can interact with
Sladjana Zagorac, Laura Garcia-Bermejo, Bruno Sainz   +2 more
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Therapeutic potential of HDAC6 in amyotrophic lateral sclerosis

Cell Stress, 2017
Amyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron disease in adults and no effective treatments exist. Mutations in FUS are one of the genetic causes of familial ALS. We used induced pluripotent stem cells (iPSCs) derived from FUS-
Wenting Guo, Ludo Van Den Bosch
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Acetylation phenotype in squamous cell lung cancer

JKS (Jurnal Kedokteran Syiah Kuala), 2009
Abstrak.   Risiko  kanker dipengaruhi   oleh   faktor   host dan lingkungan.    Bahan  dari lingkungan   yang   banyak menyebabkan   kanker   paru-paru   adalah   metabolite   dalam  asap   rokok,    Squamous    sel   kanker   paru-paru merupakan   jenis 
Mulyadi Mulyadi
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Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Viruses, 2013
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators.
Ileana M. Cristea, Benjamin A. Diner, Hanna G. Budayeva, Amanda J. Guise   +3 more
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Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity.

PLoS Genetics
Proteostasis, the maintenance of cellular protein balance, is essential for cell viability and is highly conserved across all organisms. Newly synthesized proteins, or "clients," undergo sequential processing by Hsp40, Hsp70, and Hsp90 chaperones to ...
Siddhi Omkar, Megan M Mitchem, Joel R Hoskins, Courtney Shrader, Jake T Kline, Nitika, Luca Fornelli, Sue Wickner, Andrew W Truman   +8 more
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SIRT7-mediated deacetylation of XRCC6 at lysine 591 drives breast cancer progression

Frontiers in Oncology
RationaleThe acetylation level of XRCC6 is significantly decreased in clinical breast cancer tissues compared with paracancerous tissues; however, the relationship between this alteration and the occurrence and development of breast cancer remains ...
Jie Yin, Jiaxing Liu, Meirui He, Tang Xiao, Wenjuan Xiang, Ruxia Sheng, Haifang Zhao, Xinyue Huang, Sheng Xu, Yong Zhou, Junfeng Liu, Ruijuan Heng, Xiaoying He, Yunxiang Wang, Yu Song, Pan Qi   +15 more
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Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments

BMC Genomics
Background The deep-sea cold seep zone is characterized by high pressure, low temperature, darkness, and oligotrophy. Vesicomyidae clams are the dominant species within this environment, often forming symbiotic relationships with chemosynthetic microbes.
Xue Kong, Wei Wang, Sunan Chen, Manzong Song, Ying Zhi, Yuefeng Cai, Haibin Zhang, Xin Shen   +7 more
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ELM2‐SANT Domain‐Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human‐Induced Pluripotent Stem Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background ELMSAN1 (ELM2‐SANT domain‐containing scaffolding protein 1) is a newly identified scaffolding protein of the MiDAC (mitotic deacetylase complex), playing a pivotal role in early embryonic development.
Yu‐An Lu, Jiacheng Sun, Lu Wang, Meimei Wang, Yalin Wu, Anteneh Getachew, Rachel C. Matthews, Hui Li, William Gao Peng, Jianyi Zhang, Rui Lu, Yang Zhou   +11 more
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HOXA10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through HDAC1

Cancer Management and Research, 2019
Yi Zhang, Jie Chen, Shan-Shan Wu, Meng-Jiao Lv, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen, Guo-Qing ZangDepartment of Infectious Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic
Zhang Y, Chen J, Wu SS, Lv MJ, Yu YS, Tang ZH, Chen XH, Zang GQ   +7 more
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