Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection [PDF]
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Joanne Clark-Matott +2 more
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An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase [PDF]
Communications Biology, 2020 Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.
Chu-Ya Wu +8 more
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Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma [PDF]
Clinical and Molecular HepatologyBackground/Aims Acetyl coenzyme A (acetyl-CoA) is one of the most essential metabolites in cell metabolism but its function and concentration in hepatocellular carcinoma (HCC) remain elusive and controversial.
Shan Li +12 more
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Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast [PDF]
mBio, 2014 The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for cost-efficient production of novel fuels and chemicals requires high yields and low by-product ...
Jens Nielsen
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Regulation of
mSphere, 2018 To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T.
Sunayan S. Ray +2 more
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Inhibition of Histone Lysine Acetyltransferases by Coenzyme A Analogs [PDF]
MoleculesHistone lysine acetylation is a widespread posttranslational modification, essential for vital functions in eukaryotic organisms. Histone lysine acetyltransferases (KATs) employ acetyl-coenzyme A as a universal acetyl donor for acetylation of lysine ...
Faidra Voukia +3 more
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in
mBio, 2019 During growth, microorganisms have to balance metabolic flux between energy and biosynthesis. One of the key intermediates in central carbon metabolism is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or ...
Katharina Kremer +8 more
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Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery [PDF]
International Journal of Molecular Sciences, 2020 Yevgeniya I Shurubor +2 more
exaly +2 more sources
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A [PDF]
Cell Metabolism, 2019 Sung Min Son +2 more
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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. [PDF]
PLoS ONE, 2014 Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
Nicola Laurieri +7 more
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