Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection [PDF]
Molecules, 2017 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) play essential roles in cell energy metabolism. Dysregulation of the biosynthesis and functioning of both compounds may contribute to various pathological conditions.
Boris Krasnikov, Joanne Clark-Matott
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An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase [PDF]
Communications Biology, 2020 Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.
Chu-Ya Wu +8 more
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Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma [PDF]
Clinical and Molecular HepatologyBackground/Aims Acetyl coenzyme A (acetyl-CoA) is one of the most essential metabolites in cell metabolism but its function and concentration in hepatocellular carcinoma (HCC) remain elusive and controversial.
Shan Li +12 more
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Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast [PDF]
mBio, 2014 The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and pharmaceuticals. The use of this cell factory for cost-efficient production of novel fuels and chemicals requires high yields and low by-product ...
Jens Nielsen
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Regulation of
mSphere, 2018 To satisfy its fatty acid needs, the extracellular eukaryotic parasite Trypanosoma brucei relies on two mechanisms: uptake of fatty acids from the host and de novo synthesis. We hypothesized that T.
Sunayan S. Ray +2 more
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Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in
mBio, 2019 During growth, microorganisms have to balance metabolic flux between energy and biosynthesis. One of the key intermediates in central carbon metabolism is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or ...
Katharina Kremer +8 more
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Advances in mitochondrial compartmentalization for terpenoid synthesis in Saccharomyces cerevisiae [PDF]
Frontiers in Bioengineering and BiotechnologyMitochondria provide a unique enriched acetyl coenzyme A reservoir and an ideal redox environment, offering an efficient supply for the biosynthesis of terpene precursors and terpene products.
Chuyi Zheng, Chuyi Zheng, Tian Ma
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Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life [PDF]
eLifeAlthough lifespan has long been the focus of ageing research, preventing functional decline late in life is a more pressing societal need. Here, we investigate the basis of senescence and declining fitness during replicative ageing in budding yeast, and ...
Hanane Hadj-Moussa +4 more
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Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery [PDF]
International Journal of Molecular Sciences, 2020 Boris Krasnikov, M Flint Beal
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From metabolites to chromatin: ACSS2-driven acetyl-CoA fuels H3K27ac chromatin remodeling in HBV-associated HCC: Editorial on “Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma” [PDF]
Clinical and Molecular HepatologyHyeong-Jin Cho, Sung-Gyoo Park
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