Results 1 to 10 of about 92,949 (326)

Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]

Frontiers in Pharmacology, 2023
Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren   +5 more
doaj   +3 more sources

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]

Cell Reports, 2023
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech   +18 more
doaj   +3 more sources

Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

Molecules, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu, Jing Zhong, Dixian Luo, Jingjing Tan, Qinghai Zhang, Ying Wu, Jianghua Liu, Renxian Cao, Gebo Wen, Deliang Cao   +9 more
doaj   +7 more sources

Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Frontiers in Microbiology, 2021
Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Pan Wang, Pan Wang, Pan Wang, Xin Wang, Xin Wang, Xin Wang, Ying Yin, Ying Yin, Ying Yin, Mingliang He, Mingliang He, Mingliang He, Wei Tan, Wei Tan, Wei Tan, Wenting Gao, Wenting Gao, Wenting Gao, Jianping Wen, Jianping Wen, Jianping Wen   +20 more
doaj   +2 more sources

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

Nature Communications, 2016
Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a
Moritz Hunkeler, Edward Stuttfeld, Anna Hagmann, Stefan Imseng, Timm Maier   +4 more
doaj   +2 more sources

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase. [PDF]

Sci Adv
Human acetyl-CoA carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown.
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q.   +5 more
europepmc   +2 more sources

Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants

Nature Communications, 2020
In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking ...
Yajin Ye, Krisztina Nikovics, Alexandra To, Loïc Lepiniec, Eric T. Fedosejevs, Steven R. Van Doren, Sébastien Baud, Jay J. Thelen   +7 more
doaj   +2 more sources

Acetyl-CoA carboxylase obstructs CD8⁺ T cell lipid utilization in the tumor microenvironment. [PDF]

Cell Metab
SUMMARY The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival.
Hunt EG, Hurst KE, Riesenberg BP, Kennedy AS, Gandy EJ, Andrews AM, Del Mar Alicea Pauneto C, Ball LE, Wallace ED, Gao P, Meier J, Serody JJ, Coleman MF, Thaxton JE.   +13 more
europepmc   +2 more sources

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]

Bio-Protocol
Fatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun, Jiachen Li, Lianmei Zhao, Hongtao Zhu   +3 more
doaj   +2 more sources

Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function

Nature Communications, 2022
Here the authors report that inhibition of de novo fatty acid synthesis by deleting the enzyme Acetyl-CoA-Carboxylase 1 in the intestinal epithelium results in the loss of crypt structures and a specific decline in Lgr5+ intestinal epithelial stem cells.
Shuting Li, Chia-Wen Lu, Elia C. Diem, Wang Li, Melanie Guderian, Marc Lindenberg, Friederike Kruse, Manuela Buettner, Stefan Floess, Markus R. Winny, Robert Geffers, Hans-Hermann Richnow, Wolf-Rainer Abraham, Guntram A. Grassl, Matthias Lochner   +14 more
doaj   +2 more sources