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ACETYL-COA-CARBOXYLASE FROM CANDIDA ALBICANS
1999SCHNELL NORBERT FRIEDEMANN +4 more
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The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
Nature Communications, 2016 Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a
Moritz Hunkeler +4 more
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Chemical Genetics of Acetyl-CoA Carboxylases [PDF]
Molecules, 2013 Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu +9 more
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Targeting acetyl-CoA carboxylase 1 for cancer therapy
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
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Frontiers in Microbiology, 2021 Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Pan Wang +20 more
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Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland [PDF]
, 2005 We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate 40% more calories when offered a high-fat diet and gained weight at three times the rate of controls. They exhibited
Kelly, Paul A. +4 more
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