Results 1 to 10 of about 138,584 (219)
Pyruvate carboxylase and cancer progression [PDF]
Cancer & Metabolism, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Violet A. Kiesel +7 more
doaj +6 more sources
Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis [PDF]
Frontiers in Psychiatry, 2021 In vivo1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility.
Jun Shen, Jyoti Singh Tomar
doaj +3 more sources
The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase [PDF]
Nature Communications, 2022 Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ...
Alastair G. Kerr +12 more
doaj +3 more sources
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis [PDF]
BMC Cancer, 2021 Background Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC ...
Chang Liu +4 more
doaj +3 more sources
Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Cell Reports, 2016 Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine ...
Koen Veys +2 more
exaly +4 more sources
mBio, 2022 In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Larissa Krüger +8 more
doaj +2 more sources
Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet. [PDF]
J Biol Chem, 2022 Pyruvate has two major fates upon entry into mitochondria, the oxidative decarboxylation to acetyl-CoA via the pyruvate decarboxylase complex or the biotin-dependent carboxylation to oxaloacetate via pyruvate carboxylase (Pcx).
Selen ES +5 more
europepmc +2 more sources
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. [PDF]
Nat Metab, 2021 The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production of extracellular matrix proteins as the ...
Schwörer S +6 more
europepmc +2 more sources
Cell Reports, 2021 SUMMARY Glucose metabolism modulates the islet β cell responses to diabetogenic stress, including inflammation. Here, we probed the metabolic mechanisms that underlie the protective effect of glucose in inflammation by interrogating the metabolite ...
Loren Walensky +2 more
exaly +2 more sources
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]
Nature Communications, 2022 Pyruvate Carboxylase is a multifunctional enzyme that follows a multi-pathway reaction. Here, the authors, using cryoEM and classification techniques, reveal several catalytic states at reaction sites, the interplay between them, and their relationship ...
Jorge Pedro López-Alonso +5 more
doaj +2 more sources