Pyruvate carboxylase and cancer progression [PDF]
Cancer & Metabolism, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Violet A. Kiesel +7 more
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CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]
Nature Communications, 2022 Pyruvate Carboxylase is a multifunctional enzyme that follows a multi-pathway reaction. Here, the authors, using cryoEM and classification techniques, reveal several catalytic states at reaction sites, the interplay between them, and their relationship ...
Jorge Pedro López-Alonso +5 more
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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression [PDF]
Breast Cancer ResearchBackground Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are not fully understood.
Michael F. Coleman +17 more
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Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency [PDF]
Advances in Laboratory MedicinePyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge Eresha +12 more
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Pyruvate carboxylase promotes SREBP1a-mediated lipid synthesis in epithelial ovarian cancer [PDF]
Communications BiologyEpithelial ovarian cancer (EOC) is characterized by late diagnosis and high recurrence, with dysregulated lipid metabolism emerging as a hallmark of progression.
Xinyun Huang +5 more
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Pyruvate carboxylase is critical for biofilm formation in Mycobacterium tuberculosis [PDF]
npj Biofilms and MicrobiomesMycobacterium tuberculosis (Mtb) forms biofilms. Biofilm formation is critical in Mtb’s virulence. The metabolic pathways governing mycobacterial biofilm formation remain largely unexplored. This study evaluated how different carbon sources influence Mtb
Shweta Singh +2 more
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The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase [PDF]
Nature Communications, 2022 Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ...
Alastair G. Kerr +12 more
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Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway [PDF]
Advanced ScienceAtherosclerosis (AS) is a major cause of cardiovascular diseases, driven by chronic inflammation and macrophage polarization toward a proinflammatory phenotype.
Ling‐Na Zhao +17 more
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Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Cell Reports, 2016 Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine ...
Koen Veys +2 more
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Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence [PDF]
Journal of DiabetesYumei Yang, Baomin Wang, Xiaomu Li
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