Results 41 to 50 of about 27,529 (245)

Pyruvate-dependent regulation of lactate metabolism in HEK cells with HKs knocked-down.

, 2023
Addition of cytosolic pyruvate activates the TCA cycle “A”, which then activates the malate aspartate shuttle (MAS) “B” to facilitate the transformation of lactate into pyruvate in the mitochondrial intermembrane space “phase 2”.
Scott John (228011), Guillaume Calmettes (252956), Bernard Ribalet (228017), Shili Xu (440037)   +3 more
core   +1 more source

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco, Aaron Williams, Claudia Soler‐Alfonso, Emily Waskow, Elizabeth Mizerik, Fernando Scaglia, Chaya N. Murali   +6 more
wiley   +1 more source

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

Nature Communications, 2016
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate ...
Xiaomu Li, Kenneth K. Y. Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Xue Jiang, Yawen Zhou, Philip Hallenborg, Ruby L. C. Hoo, Karen S. L. Lam, Yasuhiro Ikeda, Xin Gao, Aimin Xu   +12 more
doaj   +1 more source

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

Neurobiology of Disease, 2013
Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain although the huntingtin protein is expressed broadly in various neural cell types, including astrocytes.
William Lee, Reno C. Reyes, Manoj K. Gottipati, Karon Lewis, Mathieu Lesort, Vladimir Parpura, Michelle Gray   +6 more
doaj   +1 more source

Metabolic profiling of glioblastoma stem cells reveals pyruvate carboxylase as a critical survival factor and potential therapeutic target. [PDF]

Neuro Oncol
International audienceBackground Glioblastoma (GBM) is a highly aggressive tumor with unmet therapeutic needs, which can be explained by extensive intra-tumoral heterogeneity and plasticity.
Renoult O, Laurent-Blond M, Awada H, Oliver L, Joalland N, Croyal M, Paris F, Gratas C, Pecqueur C.   +8 more
europepmc   +2 more sources

Elektroenzymatische CO2‐Fixierung

Angewandte Chemie, EarlyView.
Die elektroenzymatische CO2‐Fixierung ermöglicht eine energieeffiziente, hochselektive Synthese komplexer Moleküle. Um ihr volles Potenzial auszuschöpfen, ist ein grundlegendes Verständnis von elektrodengekoppelten Reduktasen und Carboxylasen erforderlich.
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source

Kinetic modelling of β‐cell metabolism reveals control points in the insulin‐regulating pyruvate cycling pathways

IET Systems Biology, 2023
Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β‐cells in response to elevated glucose levels. Insulin is released in a biphasic manner in response to glucose metabolism in β‐cells.
Rahul Rahul, Adam R. Stinchcombe, Jamie W. Joseph, Brian Ingalls   +3 more
doaj   +1 more source

The phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node in C. glutamicum.

, 2016
Abbreviations: AK, acetate kinase; PTA, phosphotransacetylase; CA, carbonic anhydrase; CS, citrate synthase; ACN, aconitase; ICD, isocitrate dehydrogenase; OGDHC, oxoglutarate dehydrogenase complex; ICL, isocitrate lyase; MS, malate synthase; MalE, malic
Bernhard J. Eikmanns (2633149), Adnan Shah (2633152)   +1 more
core   +1 more source

Electroenzymatic CO2 Fixation

Angewandte Chemie International Edition, EarlyView.
Electroenzymatic CO2 fixation enables energy‐efficient, highly selective synthesis of complex molecules. Unlocking its full potential requires fundamental understanding of electrode‐coupled reductases and carboxylases. This review critically discusses available enzymes, product scope, and key thermodynamic and kinetic considerations, highlighting ...
Leonardo Castañeda‐Losada, Michael Richter, Christophe Léger, Vincent Fourmond, Nicolas Plumeré   +4 more
wiley   +1 more source

Pyruvate carboxylase and N. Crassa suc mutants

, 1973
Pyruvate carboxylase and N.
Beever, R. E., R. E. Beever
core   +1 more source