Results 41 to 50 of about 138,584 (219)

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Cell Metabolism, 2022
Summary The tumor microenvironment (TME) is a unique metabolic niche that can inhibit T cell metabolism and cytotoxicity. To dissect the metabolic interplay between tumors and T cells, we establish an in vitro system that recapitulates the metabolic ...
Ilaria Elia, Jared H. Rowe, Sheila Johnson, Shakchhi Joshi, G. Notarangelo, Kiran Kurmi, G. Freeman, A. Sharpe, M. Haigis   +8 more
semanticscholar   +1 more source

Metabolic engineering of fast-growing Vibrio natriegens for efficient pyruvate production

Microbial Cell Factories, 2023
Background Pyruvate is a widely used value-added chemical which also serves as a hub of various metabolic pathways. The fastest-growing bacterium Vibrio natriegens is a promising chassis for synthetic biology applications with high substrate uptake rates.
Fengli Wu, Shucai Wang, Yanfeng Peng, Yufeng Guo, Qinhong Wang   +4 more
doaj   +1 more source

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

Cell Metabolism, 2019
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose ...
Curtis C. Hughey, P. Crawford
semanticscholar   +1 more source

Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells. [PDF]

PLoS ONE, 2013
Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM).
Jianhui Liu, Lixia Guo, Fei Yin, Yonglan Zhang, Zixuan Liu, Yanwen Wang   +5 more
doaj   +1 more source

Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP/NAD(P)H-free chemoenzymatic system

Nature Communications, 2023
The use of gaseous and air-captured CO_2 for technical biosynthesis is highly desired but challenging due to high energy demands. Here, the authors present an ATP and NAD(P)H-free chemoenzymatic system for glycine, serine, and pyruvate biosynthesis by ...
Jianming Liu, Han Zhang, Yingying Xu, Hao Meng, A. Zeng   +4 more
semanticscholar   +1 more source

Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

Nature Communications, 2018
Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate ...
Yumeng Liu, Melissa M. Budelier, Katelyn Stine, Martin St. Maurice   +3 more
doaj   +1 more source

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1Research in Context

EBioMedicine, 2018
Background: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood.
Aiyun Li, Qun Liu, Qiang Li, Baolin Liu, Yang Yang, Ning Zhang   +5 more
doaj   +1 more source

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

Advanced Science, EarlyView.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li, Jun‐Jie Zhangyang, Bing‐Zhi Li, Zhi‐Hua Liu, Ying‐Jin Yuan   +4 more
wiley   +1 more source

Inhibition of pyruvate carboxylase by 1α,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression

Cancer Letters, 2017
Maintaining reductive-oxidative (redox) balance is an essential feature in breast cancer cell survival, with cellular metabolism playing an integral role in maintaining redox balance through its supply of reduced NADPH. In the present studies, the effect
Tomasz Wilmanski, Xuanzhu Zhou, Wei Zheng, Aparna B. Shinde, S. Donkin, Michael K. Wendt, J. Burgess, D. Teegarden   +7 more
semanticscholar   +1 more source

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

Neurobiology of Disease, 2013
Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain although the huntingtin protein is expressed broadly in various neural cell types, including astrocytes.
William Lee, Reno C. Reyes, Manoj K. Gottipati, Karon Lewis, Mathieu Lesort, Vladimir Parpura, Michelle Gray   +6 more
doaj   +1 more source