Results 21 to 30 of about 138,584 (219)
PC Splice-Site Variant c.1825+5G>A Caused Intron Retention in a Patient With Pyruvate Carboxylase Deficiency: A Case Report [PDF]
Frontiers in Pediatrics, 2022 BackgroundPyruvate carboxylase deficiency (PCD; MIM#266150) is a rare autosomal recessive disorder characterized by a wide range of clinical features, including delayed neurodevelopment, elevated pyruvate levels, lactic acidosis, elevated ketone levels ...
DongYing Tao +6 more
doaj +2 more sources
Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence [PDF]
Journal of DiabetesYumei Yang, Baomin Wang, Xiaomu Li
doaj +2 more sources
Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]
Nature Communications, 2022 Jorge Pedro López-Alonso +6 more
doaj +2 more sources
A case of pyruvate carboxylase deficiency with longer survival and normal laboratory findings.
Acta Medica Iranica, 2021 Pyruvate carboxylase deficiency (PCD) is a rare autosomal recessive defect in a biotin-containing enzyme, Pyruvate carboxylase, which is considered as an enzyme of TCA-cycle regulation, gluconeogenesis, lipogenesis, and biosynthesis of neurotransmitters.
shahin koohmanaee +7 more
doaj +1 more source
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Molecules and Cells, 2022 Pyruvate carboxylase (PC) catalyzes the two-step carboxylation of pyruvate to produce oxaloacetate, playing a key role in the maintenance of metabolic homeostasis in cells.
P. Chai +10 more
semanticscholar +1 more source
Journal of Plant Interactions, 2022 High temperature inhibits the growth and development of maize (Zea mays L.) and wheat (Triticum aestivum L.) seedlings. The current study attempts to elucidate the underlying mechanisms of exogenous trehalose for the improvement of maize and wheat ...
Ziwei Zhang, Mei Sun, Yamin Gao, Yin Luo
doaj +1 more source
Seizure, 2021 PURPOSE Our purpose was to better understand the pathogenesis of seizures associated with angiocentric glioma. Angiocentric glioma is an indolent and rare low-grade glioma. Its typical clinical presentation is with epileptic seizures. The pathogenesis of
A. Buccoliero +21 more
semanticscholar +1 more source
Metabolic engineering of CHO cells for the development of a robust protein production platform. [PDF]
PLoS ONE, 2017 Chinese hamster ovary (CHO) cells are the most preferred mammalian host used for the bio-pharmaceutical production. A major challenge in metabolic engineering is to balance the flux of the tuned heterogonous metabolic pathway and achieve efficient ...
Sanjeev Kumar Gupta +7 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source