Results 21 to 30 of about 45,700 (225)

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Cell Reports, 2016
Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine ...
Stefan Christen, Doriane Lorendeau, Roberta Schmieder, Dorien Broekaert, Kristine Metzger, Koen Veys, Ilaria Elia, Joerg Martin Buescher, Martin Franz Orth, Shawn Michael Davidson, Thomas Georg Philipp Grünewald, Katrien De Bock, Sarah-Maria Fendt   +12 more
doaj   +3 more sources

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression

Advanced Science, 2020
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood.
Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi, Mingyao Liu, Yihua Chen   +12 more
doaj   +2 more sources

Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence [PDF]

Journal of Diabetes
Yumei Yang, Baomin Wang, Xiaomu Li
doaj   +2 more sources

Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]

Nature Communications, 2022
Jorge Pedro López-Alonso, Melisa Lázaro, David Gil-Cartón, Philip H. Choi, Alexandra Dodu, Liang Tong, Mikel Valle   +6 more
doaj   +2 more sources

Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis

Frontiers in Psychiatry, 2021
In vivo1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility.
Jun Shen, Jyoti Singh Tomar
doaj   +1 more source

A case of pyruvate carboxylase deficiency with longer survival and normal laboratory findings.

Acta Medica Iranica, 2021
Pyruvate carboxylase deficiency (PCD) is a rare autosomal recessive defect in a biotin-containing enzyme, Pyruvate carboxylase, which is considered as an enzyme of TCA-cycle regulation, gluconeogenesis, lipogenesis, and biosynthesis of neurotransmitters.
shahin koohmanaee, nejat mahdie, Reza Bayat, fatemeh kharaee, Maryam Shahrokhi, Afagh Hassanzadeh Rad, Saber Najafi Chakoosari, setila dalili   +7 more
doaj   +1 more source

Exogenous trehalose differently improves photosynthetic carbon assimilation capacities in maize and wheat under heat stress

Journal of Plant Interactions, 2022
High temperature inhibits the growth and development of maize (Zea mays L.) and wheat (Triticum aestivum L.) seedlings. The current study attempts to elucidate the underlying mechanisms of exogenous trehalose for the improvement of maize and wheat ...
Ziwei Zhang, Mei Sun, Yamin Gao, Yin Luo
doaj   +1 more source

Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis

mBio, 2022
In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Larissa Krüger, Christina Herzberg, Dennis Wicke, Patricia Scholz, Kerstin Schmitt, Asan Turdiev, Vincent T. Lee, Till Ischebeck, Jörg Stülke   +8 more
doaj   +1 more source

Metabolic engineering of CHO cells for the development of a robust protein production platform. [PDF]

PLoS ONE, 2017
Chinese hamster ovary (CHO) cells are the most preferred mammalian host used for the bio-pharmaceutical production. A major challenge in metabolic engineering is to balance the flux of the tuned heterogonous metabolic pathway and achieve efficient ...
Sanjeev Kumar Gupta, Santosh K Srivastava, Ankit Sharma, Vaibhav H H Nalage, Darshita Salvi, Hiralal Kushwaha, Nikhil B Chitnis, Pratyoosh Shukla   +7 more
doaj   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source