Cell Metabolism, 2019 Summary: The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to generate TCA cycle intermediates necessary for biosynthesis without disrupting ...
Justin A Fletcher +2 more
exaly +2 more sources
Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression [PDF]
Breast Cancer ResearchBackground Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are not fully understood.
Michael F. Coleman +17 more
doaj +2 more sources
Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency [PDF]
Advances in Laboratory MedicinePyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge Eresha +12 more
doaj +2 more sources
A distinct holoenzyme organization for two-subunit pyruvate carboxylase
Nature Communications, 2016 Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected ...
Philip H. Choi +6 more
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Nature Communications, 2016 Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate ...
Xiaomu Li +12 more
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Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
Advanced Science, 2020 Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood.
Qingxiang Lin +12 more
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Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
Breast Cancer Research, 2018 Background Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression.
Aparna Shinde +4 more
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Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis
Molecular Genetics and Metabolism Reports, 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA ...
F. Habarou +13 more
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The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Cells, 2021 Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
Edward V. Prochownik, Huabo Wang
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Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway [PDF]
Advanced ScienceAtherosclerosis (AS) is a major cause of cardiovascular diseases, driven by chronic inflammation and macrophage polarization toward a proinflammatory phenotype.
Ling‐Na Zhao +17 more
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