Results 1 to 10 of about 2,701 (230)

Normoxic HIFα-mediated metabolic rewiring in cancer as a novel therapeutic target of tumor heterogeneity. [PDF]

Cancer Metab
Sánchez-Castillo A, Lommen JGE, Consten D, Savelkouls K, Barbeau LMO, Rouschop KMA, Vooijs MA, Kampen KR.   +7 more
europepmc   +1 more source

Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach. [PDF]

Biomolecules
Xiao T, Tao J, Tan J, Yi X, Wang Z, Duan X.   +5 more
europepmc   +1 more source

Lactate-induced autophagy activation: unraveling the therapeutic impact of high-intensity interval training on insulin resistance in type 2 diabetic rats. [PDF]

Sci Rep
Pirani H, Soltany A, Hossein Rezaei M, Khodabakhshi Fard A, Nikooie R, Khoramipoor K, Chamari K, Khoramipour K.   +7 more
europepmc   +1 more source

Lactobacillus Eats Amyloid Plaque and Post-Biotically Attenuates Senescence Due to Repeat Expansion Disorder and Alzheimer's Disease. [PDF]

Antioxidants (Basel)
Tyagi SC.
europepmc   +1 more source

Substrate activation of pyruvate carboxylase by pyruvate

Biochemical and Biophysical Research Communications, 1969
Abstract A kinetic analysis of pyruvate carboxylase isolated from sheep liver and using pyruvate as the variable substrate revealed non-Michaelis Menten kinetic. Double reciprocal plots were biphasic and R S values of 222 were obtained. Hill plots prepared from the initial velocity data showed that at low pyruvate concentrations, the slope of the ...
H, Taylor, J, Nielsen, D B, Keech
openaire   +2 more sources

Pyruvate carboxylase

The International Journal of Biochemistry & Cell Biology, 1998
Pyruvate carboxylase [EC 6.4.1.1] is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several
Wallace, J., Jitrapakdee, S., Chapman-Smith, A.   +2 more
openaire   +3 more sources

Amperometric sensor for pyruvate with immobilized pyruvate oxidase

Analytica Chimica Acta, 1987
Abstract Several procedures for immobilization of pyruvate oxidase by chemical bonding are reported. Attachment to nylon net was unsatisfactory in terms of yield and stability. Polyazetidine, a new commercially available prepolymer and a new nylon membrane with surface carboxyl groups provided good long-term stability, up to 30 days in the case of ...
M. Mascini, MAZZEI, Franco
openaire   +1 more source

Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex

Journal of Inherited Metabolic Disease, 1996
SummaryThe most common defect associated with deficiency of the pyruvate dehydrogenase (PDH) complex occurs in the E1 component, specifically due to mutations in the X‐linked E1α gene. Clinical sequelae of these mutations, which range from severe neonatal lactic acidosis to carbohydrate‐sensitive ataxia, can be different in males and females depending ...
B H, Robinson, N, MacKay, K, Chun, M, Ling   +3 more
openaire   +2 more sources

Pyruvate carboxylase deficiency

Journal of Inherited Metabolic Disease, 1984
AbstractThe causes of congenital lactic acidaemia are outlined. Isolated pyruvate carboxylase deficiency is reviewed in detail with a report of a recent case and a discussion of the biochemical consequences. Other causes of defective pyruvate carboxylation are described, particularly the combined carboxylase defects.
K, Bartlett, H K, Ghneim, J H, Stirk, G, Dale, K G, Alberti   +4 more
openaire   +2 more sources